KEGG   NETWORK: N01887
Entry
N01887                      Network                                
Name
Transport of chloride, GABAA receptor
Definition
GABA -> GABR -> Cl-
  Expanded
C00334 -> ((2554,2555,2556,2557,2558,2559)+(2560,2561,2562)+(2565,2566,2567)) -> C00698
Class
nt06544 Neuroactive ligand signaling
Type
Reference
Pathway
hsa04727  GABAergic synapse
hsa04082  Neuroactive ligand signaling
Gene
2554  GABRA1; gamma-aminobutyric acid type A receptor subunit alpha1
2555  GABRA2; gamma-aminobutyric acid type A receptor subunit alpha2
2556  GABRA3; gamma-aminobutyric acid type A receptor subunit alpha3
2557  GABRA4; gamma-aminobutyric acid type A receptor subunit alpha4
2558  GABRA5; gamma-aminobutyric acid type A receptor subunit alpha5
2559  GABRA6; gamma-aminobutyric acid type A receptor subunit alpha6
2560  GABRB1; gamma-aminobutyric acid type A receptor subunit beta1
2561  GABRB2; gamma-aminobutyric acid type A receptor subunit beta2
2562  GABRB3; gamma-aminobutyric acid type A receptor subunit beta3
2565  GABRG1; gamma-aminobutyric acid type A receptor subunit gamma1
2566  GABRG2; gamma-aminobutyric acid type A receptor subunit gamma2
2567  GABRG3; gamma-aminobutyric acid type A receptor subunit gamma3
Metabolite
C00334  4-Aminobutanoate
C00698  Cl-
Reference
  Authors
Cooper MS, Przebinda AS
  Title
Synaptic conversion of chloride-dependent synapses in spinal nociceptive circuits: roles in neuropathic pain.
  Journal
Pain Res Treat 2011:738645 (2011)
DOI:10.1155/2011/738645
Reference
  Authors
Higley MJ
  Title
Localized GABAergic inhibition of dendritic Ca(2+) signalling.
  Journal
Nat Rev Neurosci 15:567-72 (2014)
DOI:10.1038/nrn3803
Reference
  Authors
Govindpani K, Calvo-Flores Guzman B, Vinnakota C, Waldvogel HJ, Faull RL, Kwakowsky A
  Title
Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease.
  Journal
Int J Mol Sci 18:ijms18081813 (2017)
DOI:10.3390/ijms18081813
LinkDB

DBGET integrated database retrieval system