KEGG   NETWORK: N01892
Entry
N01892                      Network                                
Name
GABA metabolism and transport in glia
Definition
GABA(extracellular) -- GAT2/3 -> GABA(cyto) -- ABAT -> Succinate -> Glutamate -- GLUL -> Glutamine(cyto) -- SNAT3/5 -> Glutamine(extracellular)
  Expanded
C00334 -- (6540,6538) -> C00334 -- 18 -> C00042 -> C00025 -- 2752 -> C00064 -- (10991,92745) -> C00064
Class
nt06544 Neuroactive ligand signaling
Type
Reference
Pathway
hsa04727  GABAergic synapse
Gene
6540  SLC6A13; solute carrier family 6 member 13
6538  SLC6A11; solute carrier family 6 member 11
18  ABAT; 4-aminobutyrate aminotransferase
2752  GLUL; glutamate-ammonia ligase
10991  SLC38A3; solute carrier family 38 member 3
92745  SLC38A5; solute carrier family 38 member 5
Metabolite
C00334  4-Aminobutanoate
C00042  Succinate
C00025  L-Glutamate
C00064  L-Glutamine
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:32093054
  Authors
Didiasova M, Banning A, Brennenstuhl H, Jung-Klawitter S, Cinquemani C, Opladen T, Tikkanen R
  Title
Succinic Semialdehyde Dehydrogenase Deficiency: An Update.
  Journal
Cells 9:cells9020477 (2020)
DOI:10.3390/cells9020477
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
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