KEGG   NETWORK: N01906
Entry
N01906                      Network                                
Name
Glycine transport in neuron
Definition
Glycine(extracellular) -- SLC6A5/9 -> Glycine(cyto) -- SLC32A1 -> Glycine(vesicular)
  Expanded
C00037 -- (9152,6536) -> C00037 -- 140679 -> C00037
Class
nt06544 Neuroactive ligand signaling
Type
Reference
Pathway
hsa04082  Neuroactive ligand signaling
Gene
9152  SLC6A5; solute carrier family 6 member 5
6536  SLC6A9; solute carrier family 6 member 9
140679  SLC32A1; solute carrier family 32 member 1
Metabolite
C00037  Glycine
Reference
  Authors
Shimizu-Okabe C, Kobayashi S, Kim J, Kosaka Y, Sunagawa M, Okabe A, Takayama C
  Title
Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord.
  Journal
Int J Mol Sci 23:ijms23020834 (2022)
DOI:10.3390/ijms23020834
Reference
  Authors
Harvey RJ, Yee BK
  Title
Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain.
  Journal
Nat Rev Drug Discov 12:866-85 (2013)
DOI:10.1038/nrd3893
Reference
  Authors
Supplisson S, Roux MJ
  Title
Why glycine transporters have different stoichiometries.
  Journal
FEBS Lett 529:93-101 (2002)
DOI:10.1016/s0014-5793(02)03251-9
Reference
  Authors
Harvey RJ, Carta E, Pearce BR, Chung SK, Supplisson S, Rees MI, Harvey K
  Title
A critical role for glycine transporters in hyperexcitability disorders.
  Journal
Front Mol Neurosci 1:1 (2008)
DOI:10.3389/neuro.02.001.2008
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