KEGG   NETWORK: N01929
Entry
N01929                      Network                                
Name
Peroxidation and deglycosylation of acylglucosylceramide
Definition
Acyl-GlcCer -- ALOX12B+ALOXE3+SDR9C7,EPHX2,EPHX3+GBA1,GBA2 -> omega-OH-Cer -- TGM1 -> IVL
  Expanded
C23030 -- 242+59344+121214,2053,79852+2629,57704 -> C23028 -- 7051 -> 3713
Class
nt06545 Cornified envelope formation
Type
Reference
Pathway
hsa04382 Cornified envelope formation   
Disease
H00734 Autosomal recessive congenital ichthyosis   
Gene
242  ALOX12B; arachidonate 12-lipoxygenase, 12R type
59344  ALOXE3; arachidonate epidermal lipoxygenase 3
121214  SDR9C7; short chain dehydrogenase/reductase family 9C member 7
2053  EPHX2; epoxide hydrolase 2
79852  EPHX3; epoxide hydrolase 3
2629  GBA1; glucosylceramidase beta 1
57704  GBA2; glucosylceramidase beta 2
7051  TGM1; transglutaminase 1
3713  IVL; involucrin
Metabolite
C23030  Acylglucosylceramide
C23028  Ultra-long-chain omega-hydroxyceramide
Reference
PMID:30776025
  Authors
Goleva E, Berdyshev E, Leung DY
  Title
Epithelial barrier repair and prevention of allergy.
  Journal
J Clin Invest 129:1463-1474 (2019)
DOI:10.1172/JCI124608
Reference
PMID:37965138
  Authors
Ohno Y, Nakamura T, Iwasaki T, Katsuyama A, Ichikawa S, Kihara A
  Title
Determining the structure of protein-bound ceramides, essential lipids for skin barrier function.
  Journal
iScience 26:108248 (2023)
DOI:10.1016/j.isci.2023.108248
Reference
PMID:39113292
  Authors
Rawlings AV, Lane ME, Voegeli R
  Title
The importance of stratum corneum omega-linoleoyloxyacylceramides in human skin barrier health: their biochemistry, processing enzymes and metabolites involved  in corneocyte lipid envelope maturation.
  Journal
Int J Cosmet Sci 46:623-642 (2024)
DOI:10.1111/ics.12955
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