KEGG   REACTION: R01213
Entry
R01213                      Reaction                               
Name
acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming);
3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)
Definition
alpha-Isopropylmalate + CoA <=> Acetyl-CoA + 3-Methyl-2-oxobutanoic acid + H2O
Equation
C02504 + C00010 <=> C00024 + C00141 + C00001
Reaction class
RC00004  C00010_C00024
RC00470  C00141_C02504
RC02754  C00024_C02504
Enzyme
2.3.3.13
Pathway
rn00290  Valine, leucine and isoleucine biosynthesis
rn00620  Pyruvate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.13
     R01213  alpha-Isopropylmalate + CoA <=> Acetyl-CoA + 3-Methyl-2-oxobutanoic acid + H2O
Orthology
K01649  2-isopropylmalate synthase [EC:2.3.3.13]
Other DBs
RHEA: 21527
LinkDB

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