KEGG   REACTION: R02356
Entry
R02356                      Reaction                               
Definition
Estrone + H+ + Oxygen + NADPH <=> 16alpha-Hydroxyestrone + NADP+ + H2O
Equation
Reaction class
RC00001  C00005_C00006
RC00704  C00468_C05300
Enzyme
1.14.14.1       1.14.14.-
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Orthology
K07424  cytochrome P450 family 3 subfamily A [EC:1.14.14.1]
K17689  cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
K17690  cytochrome P450 family 3 subfamily A5 [EC:1.14.14.1]
Reference
1  [PMID:11861789]
  Authors
Lee AJ, Mills LH, Kosh JW, Conney AH, Zhu BT.
  Title
NADPH-dependent metabolism of estrone by human liver microsomes.
  Journal
J Pharmacol Exp Ther 300:838-49 (2002)
DOI:10.1124/jpet.300.3.838
Reference
2  [PMID:9635876]
  Authors
Huang Z, Guengerich FP, Kaminsky LS.
  Title
16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5.
  Journal
Carcinogenesis 19:867-72 (1998)
DOI:10.1093/carcin/19.5.867
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