KEGG   REACTION: R02872
Entry
R02872                      Reaction                               
Name
presqualene-diphosphate diphosphate-lyase (reducing, squalene-forming)
Definition
Presqualene diphosphate + NADPH + H+ <=> Diphosphate + Squalene + NADP+
Equation
C03428 + C00005 + C00080 <=> C00013 + C00751 + C00006
Comment
the second step of two-step reaction (see R06223, R00702+R02872)
following after R00702
Reaction class
RC00001  C00005_C00006
RC00796  C00751_C03428
Enzyme
1.3.1.96        2.5.1.21
Pathway
rn00100  Steroid biosynthesis
rn00909  Sesquiterpenoid and triterpenoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00101  Cholesterol biosynthesis, FPP => cholesterol
M00102  Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.96
     R02872  Presqualene diphosphate + NADPH + H+ <=> Diphosphate + Squalene + NADP+
 2. Transferase reactions
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.21
     R02872  Presqualene diphosphate + NADPH + H+ <=> Diphosphate + Squalene + NADP+
Orthology
K00801  farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21]
Other DBs
RHEA: 22231 22235
LinkDB

DBGET integrated database retrieval system