KEGG   REACTION: R02893
Entry
R02893                      Reaction                               
Name
17alpha,21-dihydroxy-5beta-pregnane-3,11,20-trione:NADP+ delta4-oxidoreductase
Definition
17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ <=> Cortisone + NADPH + H+
Equation
C05469 + C00006 <=> C00762 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00145  C00762_C05469
Enzyme
1.3.1.3
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.3
     R02893  17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ <=> Cortisone + NADPH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.3.1.3
   R13168  3-Oxo-5beta-steroid <=> 3-Oxo-Delta4-steroid
    R02893  17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione <=> Cortisone
Orthology
K00251  3-oxo-5-beta-steroid 4-dehydrogenase [EC:1.3.1.3]
Other DBs
RHEA: 14040
LinkDB

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