KEGG   REACTION: R02975
Entry
R02975                      Reaction                               
Name
7,8-dihydrobiopterin:NADP+ oxidoreductase
Definition
7,8-Dihydrobiopterin + NADP+ <=> Sepiapterin + NADPH + H+
Equation
C02953 + C00006 <=> C00835 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00823  C00835_C02953
Enzyme
1.1.1.153       1.1.1.184
Pathway
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.153
     R02975  7,8-Dihydrobiopterin + NADP+ <=> Sepiapterin + NADPH + H+
    1.1.1.184
     R02975  7,8-Dihydrobiopterin + NADP+ <=> Sepiapterin + NADPH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.184
   R03557  Secondary alcohol <=> Ketone
    R02975  7,8-Dihydrobiopterin <=> Sepiapterin
Orthology
K00072  sepiapterin reductase [EC:1.1.1.153]
K00079  carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]
Reference
1  [PMID:1902669]
  Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  Journal
Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P
Reference
2  [PMID:12893295]
  Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  Journal
Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9
Other DBs
RHEA: 18956
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