KEGG   REACTION: R03194
Entry
R03194                      Reaction                               
Name
S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase
Definition
2 S-Adenosyl-L-methionine + Uroporphyrinogen III <=> 2 S-Adenosyl-L-homocysteine + Precorrin 2
Equation
2 C00019 + C01051 <=> 2 C00021 + C02463
Comment
multifunctional enzyme: siroheme synthase: uroporphyrinogen III methyltransferase (R03194+R03947+R02864)
subsequently R03947
two-step reaction (R07237+R07238)
Reaction class
RC00003  C00019_C00021
RC00871  C01051_C02463
Enzyme
2.1.1.107
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Module
M00846  Siroheme biosynthesis, glutamyl-tRNA => siroheme
M00924  Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
M00925  Cobalamin biosynthesis, aerobic, uroporphyrinogen III => precorrin 2 => cobyrinate a,c-diamide
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.107
     R03194  2 S-Adenosyl-L-methionine + Uroporphyrinogen III <=> 2 S-Adenosyl-L-homocysteine + Precorrin 2
Orthology
K00589  uroporphyrin-III C-methyltransferase [EC:2.1.1.107]
K02302  uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:2.1.1.107 1.3.1.76 4.99.1.4]
K02303  uroporphyrin-III C-methyltransferase [EC:2.1.1.107]
K02496  uroporphyrin-III C-methyltransferase [EC:2.1.1.107]
K13542  uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75]
K13543  uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75]
Other DBs
RHEA: 32462
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