KEGG   REACTION: R03864
Entry
R03864                      Reaction                               
Definition
Leukotriene B4 + NADP+ <=> 12-Keto-leukotriene B4 + H+ + NADPH
Equation
C02165 + C00006 <=> C05949 + C00080 + C00005
Comment
NAD+ (see R03863)
Reaction class
RC00001  C00005_C00006
RC00241  C02165_C05949
Enzyme
1.3.1.48
Pathway
rn00590  Arachidonic acid metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.48
     R03864  Leukotriene B4 + NADP+ <=> 12-Keto-leukotriene B4 + H+ + NADPH
Orthology
K07119  prostaglandin reductase 3 [EC:1.3.1.48]
K13948  prostaglandin reductase 1 [EC:1.3.1.74 1.3.1.48]
K13949  prostaglandin reductase 2 [EC:1.3.1.48]
Reference
1  [PMID:25619643]
  Authors
Mesa J, Alsina C, Oppermann U, Pares X, Farres J, Porte S.
  Title
Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis.
  Journal
Chem Biol Interact 234:105-13 (2015)
DOI:10.1016/j.cbi.2015.01.021
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