KEGG REACTION: R04060

REACTION: R04060

Entry

R04060                      Reaction

Name

anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)

Definition

Anhydrotetracycline + Oxygen + NADPH + H+ <=> 5a,11a-Dehydrotetracycline + NADP+ + H2O

Equation

C02811 + C00007 + C00005 + C00080 <=> C03206 + C00006 + C00001

Reaction class

RC00001

C00005_C00006

RC01062

C02811_C03206

Enzyme

1.14.13.38

Pathway

rn00253

Tetracycline biosynthesis

rn01057

Biosynthesis of type II polyketide products

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00780

Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline

M00823

Chlortetracycline biosynthesis, pretetramide => chlortetracycline

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.38
     R04060  Anhydrotetracycline + Oxygen + NADPH + H+ <=> 5a,11a-Dehydrotetracycline + NADP+ + H2O

Orthology

K14256

anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase [EC:1.14.13.38 1.14.13.234]

Reference

1 [PMID:20522541]

Authors

Pickens LB, Tang Y

Title

Oxytetracycline biosynthesis.

Journal

J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419

Reference

2 [PMID:16148009]

Authors

Peric-Concha N, Borovicka B, Long PF, Hranueli D, Waterman PG, Hunter IS

Title

Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in Streptomyces rimosus results in novel polyketides with altered chain length.

Journal

J Biol Chem 280:37455-60 (2005)
DOI:10.1074/jbc.M503191200

Other DBs

RHEA:

11979

LinkDB

RCLASS: RC01062