KEGG   REACTION: R04230
Entry
R04230                      Reaction                               
Name
(R)-4'-phosphopantothenate:L-cysteine ligase (ATP-utilizing)
Definition
ATP + D-4'-Phosphopantothenate + L-Cysteine <=> AMP + Diphosphate + (R)-4'-Phosphopantothenoyl-L-cysteine
Equation
C00002 + C03492 + C00097 <=> C00020 + C00013 + C04352
Reaction class
RC00064  C00097_C04352
RC00090  C03492_C04352
Enzyme
6.3.2.51
Pathway
rn00770  Pantothenate and CoA biosynthesis
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00120  Coenzyme A biosynthesis, pantothenate => CoA
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.51
     R04230  ATP + D-4'-Phosphopantothenate + L-Cysteine <=> AMP + Diphosphate + (R)-4'-Phosphopantothenoyl-L-cysteine
Orthology
K01922  phosphopantothenate---cysteine ligase (ATP) [EC:6.3.2.51]
Reference
1  [PMID:12906824]
  Authors
Manoj N, Strauss E, Begley TP, Ealick SE.
  Title
Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution.
  Journal
Structure 11:927-36 (2003)
DOI:10.1016/S0969-2126(03)00146-1
Other DBs
RHEA: 25159
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