KEGG   REACTION: R05068
Entry
R05068                      Reaction                               
Name
(R)-2,3-dihydroxy-3-methylpentanoate:NADP+ oxidoreductase (isomerizing)
Definition
(R)-2,3-Dihydroxy-3-methylpentanoate + NADP+ <=> (R)-3-Hydroxy-3-methyl-2-oxopentanoate + NADPH + H+
Equation
C06007 + C00006 <=> C14463 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00726  C06007_C14463
Enzyme
1.1.1.86
Pathway
rn00290  Valine, leucine and isoleucine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine
M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.86
     R05068  (R)-2,3-Dihydroxy-3-methylpentanoate + NADP+ <=> (R)-3-Hydroxy-3-methyl-2-oxopentanoate + NADPH + H+
Orthology
K00053  ketol-acid reductoisomerase [EC:1.1.1.86]
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