KEGG   REACTION: R06458
Entry
R06458                      Reaction                               
Name
(2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase (10-deoxymethynolide forming)
Definition
5 (S)-Methylmalonyl-CoA + Malonyl-CoA + 5 NADPH + 5 H+ <=> 10-Deoxymethynolide + 6 CoA + 6 CO2 + 5 NADP+ + 2 H2O
Equation
5 C00683 + C00083 + 5 C00005 + 5 C00080 <=> C11993 + 6 C00010 + 6 C00011 + 5 C00006 + 2 C00001
Comment
type I polyketide synthase,PikA1-3
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C00683
RC02829  C00683_C11993
RC02830  C00683_C11993
RC02831  C00683_C11993
RC02910  C00683_C11993
RC02911  C00083_C11993
RC02915  C00683_C11993
Enzyme
2.3.1.239
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00776  Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.239
     R06458  5 (S)-Methylmalonyl-CoA + Malonyl-CoA + 5 NADPH + 5 H+ <=> 10-Deoxymethynolide + 6 CoA + 6 CO2 + 5 NADP+ + 2 H2O
Orthology
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
Other DBs
RHEA: 43059
LinkDB

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