| Entry |
|
|---|
| Definition |
6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1a'' aglycone + NADPH + Oxygen <=> 5-Oxoavermectin ''1a'' aglycone + NADP+ + H2O
|
|---|
| Equation |
|
|---|
|
 |
|---|
| Comment |
cytochrome P450 hydroxylase,AveE
|
|---|
| Reaction class |
|
|---|
| Enzyme |
1.14.-.-
|
|---|
| Pathway |
| rn00522 | Biosynthesis of 12-, 14- and 16-membered macrolides |
| rn01110 | Biosynthesis of secondary metabolites |
|
|---|
| Module |
| M00777 | Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b |
|
|---|
| Brite |
Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.- Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.-.-
R06467 6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1a'' aglycone + NADPH + Oxygen <=> 5-Oxoavermectin ''1a'' aglycone + NADP+ + H2O
|
|---|
| Orthology |
| K14372 | cytochrome P450 hydroxylase [EC:1.14.-.-] |
|
|---|
| LinkDB |
|
|---|
