| Entry |
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| Definition |
6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1b'' aglycone + NADPH + Oxygen <=> 5-Oxoavermectin ''1b'' aglycone + NADP+ + H2O
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| Equation |
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| Comment |
cytochrome P450 hydroxylase,AveE
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| Reaction class |
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| Enzyme |
1.14.-.-
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| Pathway |
| rn00522 | Biosynthesis of 12-, 14- and 16-membered macrolides |
| rn01110 | Biosynthesis of secondary metabolites |
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| Module |
| M00777 | Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b |
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| Brite |
Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.- Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.-.-
R06470 6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1b'' aglycone + NADPH + Oxygen <=> 5-Oxoavermectin ''1b'' aglycone + NADP+ + H2O
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| Orthology |
| K14372 | cytochrome P450 hydroxylase [EC:1.14.-.-] |
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| LinkDB |
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