Entry |
|
Definition |
2-Methylpropanoyl-CoA + 5 Methylmalonyl-CoA + 7 Malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1b'' aglycone + 12 CO2 + 13 CoA + 6 H2O + 9 NADP+
|
Equation |
|
|
|
Comment |
type I polyketide synthase, AveA1-4
|
Reaction class |
RC00004 | C00010_C00083 C00010_C00630 C00010_C02557 |
|
Pathway |
rn00522 | Biosynthesis of 12-, 14- and 16-membered macrolides |
rn01110 | Biosynthesis of secondary metabolites |
|
Module |
M00777 | Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b |
|
Orthology |
K14371 | avermectin polyketide synthase AveA1 |
K24567 | avermectin polyketide synthase AveA2 |
K24568 | avermectin polyketide synthase AveA3 |
K24569 | avermectin polyketide synthase AveA4 |
|
LinkDB |
|