KEGG   REACTION: R07604
Entry
R07604                      Reaction                               
Definition
2-Methyl-1-hydroxybutyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + Thiamin diphosphate
Equation
C15978 + C15972 <=> C15979 + C00068
Comment
Oxo-acid dehydrogenase complexes (see R04225), following after R07603
Reaction class
RC00027  C00068_C15978
RC00627  C15972_C15979
RC02953  C15978_C15979
Enzyme
1.2.4.4
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn00785  Lipoic acid metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.4
     R07604  2-Methyl-1-hydroxybutyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + Thiamin diphosphate
Orthology
K00166  2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]
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