KEGG   REACTION: R08208
Entry
R08208                      Reaction                               
Name
tetrahydrobiopterin:NADP+ oxidoreductase (6-pyruvoyltetrahydropterin-forming)
Definition
Tetrahydrobiopterin + 2 NADP+ <=> 6-Pyruvoyltetrahydropterin + 2 NADPH + 2 H+
Equation
C00272 + 2 C00006 <=> C03684 + 2 C00005 + 2 C00080
Comment
three-step reaction (see R01813+R11762+R11763)
Reaction class
RC00001  C00005_C00006
RC02162  C00272_C03684
Enzyme
1.1.1.153
Pathway
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00842  Tetrahydrobiopterin biosynthesis, GTP => BH4
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.153
     R08208  Tetrahydrobiopterin + 2 NADP+ <=> 6-Pyruvoyltetrahydropterin + 2 NADPH + 2 H+
Orthology
K00072  sepiapterin reductase [EC:1.1.1.153]
Reference
1  [PMID:21867484]
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
2  [PMID:9405351]
  Authors
Auerbach G, Herrmann A, Gutlich M, Fischer M, Jacob U, Bacher A, Huber R.
  Title
The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters.
  Journal
EMBO J 16:7219-30 (1997)
DOI:10.1093/emboj/16.24.7219
Other DBs
RHEA: 32630
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