KEGG   REACTION: R08255
Entry
R08255                      Reaction                               
Definition
Irinotecan + H2O <=> SN-38 + 1,4'-Bipiperidine-1'-carboxylic acid
Equation
C16641 + C00001 <=> C11173 + C16836
Comment
carboxylesterase
Reaction class
RC00475  C16641_C16836
RC00476  C11173_C16641
Enzyme
3.1.1.1
Pathway
rn00983  Drug metabolism - other enzymes
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.1
     R08255  Irinotecan + H2O <=> SN-38 + 1,4'-Bipiperidine-1'-carboxylic acid
IUBMB reaction hierarchy [BR:br08202]
 3. Hydrolase reactions
  3.1.1.1
   R00630  Ester <=> Alcohol
    R08255  Irinotecan <=> SN-38
Orthology
K01044  carboxylesterase 1 [EC:3.1.1.1]
K03927  carboxylesterase 2 [EC:3.1.1.1 3.1.1.84 3.1.1.56]
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