KEGG   REACTION: R08364
Entry
R08364                      Reaction                               
Name
2'-deoxyribonucleoside-diphosphate:trypanothione-disulfide 2'-oxidoreductase
Definition
2'-Deoxyribonucleoside diphosphate + Trypanothione disulfide + H2O <=> Ribonucleoside diphosphate + Trypanothione
Equation
C04232 + C03170 + C00001 <=> C03723 + C02090
Comment
intermediate (Tryparedoxin [CPD:C16663], see R08361+R08363)
Reaction class
RC00613  C03723_C04232
RC01003  C02090_C03170
Enzyme
1.17.4.1
Pathway
rn00480  Glutathione metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.17  Acting on CH or CH2 groups
   1.17.4  With a disulfide as acceptor
    1.17.4.1
     R08364  2'-Deoxyribonucleoside diphosphate + Trypanothione disulfide + H2O <=> Ribonucleoside diphosphate + Trypanothione
Orthology
K10807  ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
K10808  ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
LinkDB

KEGG   RCLASS: RC01003
Entry
RC01003                     RClass                                 
Definition
S1a-S3a:*-S3a:C1b-C1b
S1a-S3a:*-S3a:C1b-C1b
Reactant pair
C02090_C03170    C16563_C16564    C16567_C16568
Related class
Reaction
R03821 R08356 R08357 R08361 R08362 R08364
Enzyme
1.8.1.12        1.11.1.-        1.17.4.1
Pathway
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
Orthology
K04283  trypanothione-disulfide reductase [EC:1.8.1.12]
K10807  ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
K10808  ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K11185  cytosolic tryparedoxin peroxidase, trypanosomatid typical 2-Cys peroxiredoxin [EC:1.11.1.-]
K11186  mitochondrial tryparedoxin peroxidase, trypanosomatid typical 2-Cys peroxiredoxin [EC:1.11.1.-]

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