KEGG   REACTION: R09190
Entry
R09190                      Reaction                               
Name
6-methylpretetramide,NADPH:oxygen oxidoreductase (4,12a-hydroxylating)
Definition
6-Methylpretetramide + 2 NADPH + 2 H+ + 2 Oxygen <=> 4-Keto-anhydrotetracycline + 2 NADP+ + 2 H2O
Equation
C06629 + 2 C00005 + 2 C00080 + 2 C00007 <=> C06627 + 2 C00006 + 2 C00001
Comment
two-step reaction (see R05463+R05462)
bifunctional enzyme, OxyL
Reaction class
RC00001  C00005_C00006
RC02460  C06627_C06629
Enzyme
1.14.13.232     1.14.13.233
Pathway
rn00253  Tetracycline biosynthesis
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
Module
M00780  Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline
M00823  Chlortetracycline biosynthesis, pretetramide => chlortetracycline
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.232
     R09190  6-Methylpretetramide + 2 NADPH + 2 H+ + 2 Oxygen <=> 4-Keto-anhydrotetracycline + 2 NADP+ + 2 H2O
    1.14.13.233
     R09190  6-Methylpretetramide + 2 NADPH + 2 H+ + 2 Oxygen <=> 4-Keto-anhydrotetracycline + 2 NADP+ + 2 H2O
Orthology
K14252  6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase [EC:1.14.13.232 1.14.13.233]
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