KEGG   REACTION: R10115
Entry
R10115                      Reaction                               
Name
malonyl-[acyl-carrier protein]-methyl-ester:malonyl-[acyl-carrier protein] C-acyltransferase
Definition
Malonyl-[acp] methyl ester + Malonyl-[acyl-carrier protein] <=> 3-Ketoglutaryl-[acp] methyl ester + CO2 + Acyl-carrier protein
Equation
C19673 + C01209 <=> C20372 + C00011 + C00229
Reaction class
RC00039  C00229_C19673
RC02728  C19673_C20372
RC02888  C01209_C20372
Enzyme
2.3.1.41        2.3.1.179
Pathway
rn00780  Biotin metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00572  Pimeloyl-ACP biosynthesis, BioC-BioH pathway, malonyl-ACP => pimeloyl-ACP
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.41
     R10115  Malonyl-[acp] methyl ester + Malonyl-[acyl-carrier protein] <=> 3-Ketoglutaryl-[acp] methyl ester + CO2 + Acyl-carrier protein
    2.3.1.179
     R10115  Malonyl-[acp] methyl ester + Malonyl-[acyl-carrier protein] <=> 3-Ketoglutaryl-[acp] methyl ester + CO2 + Acyl-carrier protein
Orthology
K00647  3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41]
K09458  3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
Reference
1  [PMID:22965231]
  Authors
Lin S, Cronan JE
  Title
The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis.
  Journal
J Biol Chem 287:37010-20 (2012)
DOI:10.1074/jbc.M112.410290
LinkDB

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