KEGG   REACTION: R11107
Entry
R11107                      Reaction                               
Definition
Aminopyrrolnitrin + 2 NADPH + 2 Oxygen + 2 H+ <=> Pyrrolnitrin + 2 NADP+ + 2 H2O
Equation
C21109 + 2 C00005 + 2 C00007 + 2 C00080 <=> C12491 + 2 C00006 + 2 C00001
Comment
three-step reaction (monooxygenation, dehydrogenation and monooxygenation again)
incomplete reaction (unidentified acceptor in dehydrogenation)
Reaction class
RC00001  C00005_C00006
RC01333  C12491_C21109
Enzyme
1.14.13.-
Pathway
rn00404  Staurosporine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00790  Pyrrolnitrin biosynthesis, tryptophan => pyrrolnitrin
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-
     R11107  Aminopyrrolnitrin + 2 NADPH + 2 Oxygen + 2 H+ <=> Pyrrolnitrin + 2 NADP+ + 2 H2O
Orthology
K19982  aminopyrrolnitrin oxygenase [EC:1.14.13.-]
Reference
1  [PMID:16923884]
  Authors
Lee JK, Ang EL, Zhao H
  Title
Probing the substrate specificity of aminopyrrolnitrin oxygenase (PrnD) by mutational analysis.
  Journal
J Bacteriol 188:6179-83 (2006)
DOI:10.1128/JB.00259-06
Reference
2  [PMID:16342311]
  Authors
Lee J, Zhao H.
  Title
Mechanistic studies on the conversion of arylamines into arylnitro compounds by aminopyrrolnitrin oxygenase: identification of intermediates and kinetic studies.
  Journal
Angew Chem Int Ed Engl 45:622-5 (2006)
DOI:10.1002/anie.200502903
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