REACTION: R13276
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Entry
R13276 Reaction
Definition
Trehalose monomycolate + NADP+ <=> Trehalose mycolic-beta-ketoester + NADPH + H+
Equation
C22876
+
C00006
<=>
C22875
+
C00005
+
C00080
Comment
general reaction
Reaction class
RC00089
C22875_C22876
Pathway
rn00074
Mycolic acid biosynthesis
rn01100
Metabolic pathways
rn01110
Biosynthesis of secondary metabolites
Module
M00887
Mycolic acid biosynthesis, meromycolic acid + alpha-carboxyacyl-CoA + trehalose => TMM => TDM/mAGP/GMM
Orthology
K27306
mycolic acid reductase
Reference
1 [PMID:
31785114
]
Authors
Javid A, Cooper C, Singh A, Schindler S, Hanisch M, Marshall RL, Kalscheuer R, Bavro VN, Bhatt A.
Title
The mycolic acid reductase Rv2509 has distinct structural motifs and is essential for growth in slow-growing mycobacteria.
Journal
Mol Microbiol 113:521-533 (2020)
DOI:
10.1111/mmi.14437
Reference
2 [PMID:
27268593
]
Authors
Quemard A.
Title
New Insights into the Mycolate-Containing Compound Biosynthesis and Transport in Mycobacteria.
Journal
Trends Microbiol 24:725-738 (2016)
DOI:
10.1016/j.tim.2016.04.009
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