Entry |
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Name |
trehalose monomycolate:trehalose monomycolate 6'-mycolyltransferase
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Definition |
2 Trehalose monomycolate <=> alpha,alpha-Trehalose + Trehalose dimycolate
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Equation |
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|
 |
Comment |
general reaction
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Reaction class |
RC00041 | C01083_C22876 C22876_C22877 |
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Enzyme |
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Pathway |
rn01110 | Biosynthesis of secondary metabolites |
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Module |
M00887 | Mycolic acid biosynthesis, meromycolic acid + alpha-carboxyacyl-CoA + trehalose => TMM => TDM/mAGP/GMM |
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Brite |
Enzymatic reactions [BR:br08201]
2. Transferase reactions
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.122
R13277 2 Trehalose monomycolate <=> alpha,alpha-Trehalose + Trehalose dimycolate
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Orthology |
K18851 | diacylglycerol O-acyltransferase / trehalose O-mycolyltransferase / mycolyltransferase Ag85 [EC:2.3.1.20 2.3.1.122 2.3.1.-] |
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Reference |
|
Authors |
Takayama K, Wang C, Besra GS. |
Title |
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. |
Journal |
|
Reference |
|
Authors |
Sathyamoorthy N, Takayama K. |
Title |
Purification and characterization of a novel mycolic acid exchange enzyme from Mycobacterium smegmatis. |
Journal |
J Biol Chem 262:13417-23 (1987) |
Reference |
|
Authors |
Backus KM, Dolan MA, Barry CS, Joe M, McPhie P, Boshoff HI, Lowary TL, Davis BG, Barry CE 3rd. |
Title |
The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions. |
Journal |
|
Reference |
|
Authors |
Goins CM, Dajnowicz S, Smith MD, Parks JM, Ronning DR. |
Title |
Mycolyltransferase from Mycobacterium tuberculosis in covalent complex with tetrahydrolipstatin provides insights into antigen 85 catalysis. |
Journal |
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LinkDB |
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