KEGG   REACTION: R13277
Entry
R13277                      Reaction                               
Name
trehalose monomycolate:trehalose monomycolate 6'-mycolyltransferase
Definition
2 Trehalose monomycolate <=> alpha,alpha-Trehalose + Trehalose dimycolate
Equation
Comment
general reaction
Reaction class
RC00041  C01083_C22876  C22876_C22877
Enzyme
Pathway
rn00074  Mycolic acid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00887  Mycolic acid biosynthesis, meromycolic acid + alpha-carboxyacyl-CoA + trehalose => TMM => TDM/mAGP/GMM
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.122
     R13277  2 Trehalose monomycolate <=> alpha,alpha-Trehalose + Trehalose dimycolate
Orthology
K18851  diacylglycerol O-acyltransferase / trehalose O-mycolyltransferase / mycolyltransferase Ag85 [EC:2.3.1.20 2.3.1.122 2.3.1.-]
Reference
1  [PMID:15653820]
  Authors
Takayama K, Wang C, Besra GS.
  Title
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 18:81-101 (2005)
DOI:10.1128/CMR.18.1.81-101.2005
Reference
2  [PMID:3654621]
  Authors
Sathyamoorthy N, Takayama K.
  Title
Purification and characterization of a novel mycolic acid exchange enzyme from Mycobacterium smegmatis.
  Journal
J Biol Chem 262:13417-23 (1987)
Reference
3  [PMID:25028517]
  Authors
Backus KM, Dolan MA, Barry CS, Joe M, McPhie P, Boshoff HI, Lowary TL, Davis BG, Barry CE 3rd.
  Title
The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates  and activities determined by non-active site regions.
  Journal
J Biol Chem 289:25041-53 (2014)
DOI:10.1074/jbc.M114.581579
Reference
4  [PMID:29352107]
  Authors
Goins CM, Dajnowicz S, Smith MD, Parks JM, Ronning DR.
  Title
Mycolyltransferase from Mycobacterium tuberculosis in covalent complex with  tetrahydrolipstatin provides insights into antigen 85 catalysis.
  Journal
J Biol Chem 293:3651-3662 (2018)
DOI:10.1074/jbc.RA117.001681
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