KEGG   REACTION: R13330
Entry
R13330                      Reaction                               
Name
17-dehydropreakuammicine hydrolase (decarboxylating)
Definition
17-Dehydropreakuammicine + H2O <=> Norfluorocurarine + Methanol + CO2
Equation
Comment
norfluorocurarine synthase
Enzyme
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00980  Strychnine biosynthesis, geissoschizine => strychnine
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.123
     R13330  17-Dehydropreakuammicine + H2O <=> Norfluorocurarine + Methanol + CO2
Orthology
K27781  dehydropreakuammicine esterase [EC:3.1.1.123]
Reference
1  [PMID:35794473]
  Authors
Hong B, Grzech D, Caputi L, Sonawane P, Lopez CER, Kamileen MO, Hernandez Lozada NJ, Grabe V, O'Connor SE
  Title
Biosynthesis of strychnine.
  Journal
Nature 607:617-622 (2022)
DOI:10.1038/s41586-022-04950-4
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