KEGG REACTION: R13333

REACTION: R13333

Entry

R13333                      Reaction

Name

17,18-epoxy-17-hydroxycur-19-ene:NADP+ oxidoreductase

Definition

18-Hydroxynorfluorocurarine + NADPH + H+ <=> Wieland-Gumlich aldehyde + NADP+

Equation

C22924 + C00005 + C00080 <=> C22925 + C00006

Comment

Wieland-Gumlich aldehyde synthase

Reaction class

RC03589

C22924_C22925

Enzyme

1.5.1.57

Pathway

rn00901

Indole alkaloid biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00980

Strychnine biosynthesis, geissoschizine => strychnine

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.57
     R13333  18-Hydroxynorfluorocurarine + NADPH + H+ <=> Wieland-Gumlich aldehyde + NADP+

Orthology

K27783

18-hydroxynorfluorocurarine reductase [EC:1.5.1.57]

Reference

1 [PMID:35794473]

Authors

Hong B, Grzech D, Caputi L, Sonawane P, Lopez CER, Kamileen MO, Hernandez Lozada NJ, Grabe V, O'Connor SE

Title

Biosynthesis of strychnine.

Journal

Nature 607:617-622 (2022)
DOI:10.1038/s41586-022-04950-4

LinkDB

RCLASS: RC03589