KEGG   REACTION: R13338
Entry
R13338                      Reaction                               
Name
strychnine,[NADPH---hemoprotein reductase]:oxygen oxidoreductase (10-hydroxylating)
Definition
Strychnine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 10-Hydroxystrychnine + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C06522 + C03024 + C00007 <=> C22929 + C03161 + C00001
Reaction class
RC00490  C06522_C22929
Enzyme
1.14.14.189
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.189
     R13338  Strychnine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 10-Hydroxystrychnine + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K27786  strychnine 10-hydroxylase [EC:1.14.14.189]
Reference
1  [PMID:35794473]
  Authors
Hong B, Grzech D, Caputi L, Sonawane P, Lopez CER, Kamileen MO, Hernandez Lozada NJ, Grabe V, O'Connor SE
  Title
Biosynthesis of strychnine.
  Journal
Nature 607:617-622 (2022)
DOI:10.1038/s41586-022-04950-4
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