KEGG   REACTION: R13446
Entry
R13446                      Reaction                               
Definition
(2R)-2-Hydroxy-4-(methylsulfanyl)butanoate + NADP+ <=> 4-Methylthio-2-oxobutanoic acid + NADPH + H+
Equation
C22315 + C00006 <=> C01180 + C00005 + C00080
Comment
MTOB reductase
Reaction class
RC00031  C01180_C22315
Enzyme
1.1.1.-
Pathway
rn00920  Sulfur metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R13446  (2R)-2-Hydroxy-4-(methylsulfanyl)butanoate + NADP+ <=> 4-Methylthio-2-oxobutanoic acid + NADPH + H+
Reference
1  [PMID:38862603]
  Authors
Wang J, Curson ARJ, Zhou S, Carrion O, Liu J, Vieira AR, Walsham KS, Monaco S, Li CY, Dong QY, Wang Y, Rivera PPL, Wang XD, Zhang M, Hanwell L, Wallace M, Zhu XY, Leao PN, Lea-Smith DJ, Zhang YZ, Zhang XH, Todd JD.
  Title
Alternative dimethylsulfoniopropionate biosynthesis enzymes in diverse and  abundant microorganisms.
  Journal
Nat Microbiol 9:1979-1992 (2024)
DOI:10.1038/s41564-024-01715-9
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