KEGG   REACTION: R13461
Entry
R13461                      Reaction                               
Name
(25R)-3-oxocholest-4-en-26-oate:CoA ligase (AMP-forming)
Definition
(25R)-3-Oxocholest-4-en-26-oate + ATP + CoA <=> (25R)-3-Oxocholest-4-en-26-oyl-CoA + AMP + Diphosphate
Equation
C20839 + C00002 + C00010 <=> C23011 + C00020 + C00013
Reaction class
RC00137  C20839_C23011
Enzyme
6.2.1.42
Pathway
rn00984  Steroid degradation
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.42
     R13461  (25R)-3-Oxocholest-4-en-26-oate + ATP + CoA <=> (25R)-3-Oxocholest-4-en-26-oyl-CoA + AMP + Diphosphate
Orthology
K18688  3-oxocholest-4-en-26-oate---CoA ligase [EC:6.2.1.42]
Reference
1  [PMID:26161441]
  Authors
Yang M, Lu R, Guja KE, Wipperman MF, St Clair JR, Bonds AC, Garcia-Diaz M, Sampson NS
  Title
Unraveling Cholesterol Catabolism in Mycobacterium tuberculosis: ChsE4-ChsE5 alpha2beta2 Acyl-CoA Dehydrogenase Initiates beta-Oxidation of 3-Oxo-cholest-4-en-26-oyl CoA.
  Journal
ACS Infect Dis 1:110-125 (2015)
DOI:10.1021/id500033m
Reference
2  [PMID:33826843]
  Authors
Yuan T, Werman JM, Yin X, Yang M, Garcia-Diaz M, Sampson NS.
  Title
Enzymatic beta-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis  Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA.
  Journal
ACS Infect Dis 7:1739-1751 (2021)
DOI:10.1021/acsinfecdis.1c00069
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