KEGG   REACTION: R13463
Entry
R13463                      Reaction                               
Definition
(25S)-3-Oxocholest-4-en-26-oyl-CoA + Acceptor <=> 3-Oxocholest-4,24-dien-26-oyl-CoA + Reduced acceptor
Equation
C20840 + C00028 <=> C23010 + C00030
Comment
3-oxocholest-4-en-26-oyl-CoA dehydrogenase
Reaction class
RC01942  C20840_C23010
Enzyme
1.3.99.-
Pathway
rn00984  Steroid degradation
rn01120  Microbial metabolism in diverse environments
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.99  With unknown physiological acceptors
    1.3.99.-
     R13463  (25S)-3-Oxocholest-4-en-26-oyl-CoA + Acceptor <=> 3-Oxocholest-4,24-dien-26-oyl-CoA + Reduced acceptor
Orthology
K22818  3-oxocholest-4-en-26-oyl-CoA dehydrogenase alpha subunit [EC:1.3.99.-]
K22819  3-oxocholest-4-en-26-oyl-CoA dehydrogenase beta subunit [EC:1.3.99.-]
Reference
1  [PMID:26161441]
  Authors
Yang M, Lu R, Guja KE, Wipperman MF, St Clair JR, Bonds AC, Garcia-Diaz M, Sampson NS
  Title
Unraveling Cholesterol Catabolism in Mycobacterium tuberculosis: ChsE4-ChsE5 alpha2beta2 Acyl-CoA Dehydrogenase Initiates beta-Oxidation of 3-Oxo-cholest-4-en-26-oyl CoA.
  Journal
ACS Infect Dis 1:110-125 (2015)
DOI:10.1021/id500033m
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