KEGG   REACTION: R13471
Entry
R13471                      Reaction                               
Name
3-oxopregnene-20-carboxyl-CoA:acetyl-CoA C-acyltransferase
Definition
3,22-Dioxochol-4-en-24-oyl-CoA + CoA <=> 3-Oxopregnene-20-carboxyl-CoA + Acetyl-CoA
Equation
C23016 + C00010 <=> C23017 + C00024
Enzyme
2.3.1.16
Pathway
rn00984  Steroid degradation
rn01120  Microbial metabolism in diverse environments
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.16
     R13471  3,22-Dioxochol-4-en-24-oyl-CoA + CoA <=> 3-Oxopregnene-20-carboxyl-CoA + Acetyl-CoA
IUBMB reaction hierarchy [BR:br08202]
 2. Transferase reactions
  2.3.1.16
   R00391  Acyl-CoA <=> 3-Oxoacyl-CoA
    R13471  3-Oxopregnene-20-carboxyl-CoA <=> 3,22-Dioxochol-4-en-24-oyl-CoA
Orthology
K00632  acetyl-CoA acyltransferase [EC:2.3.1.16]
Reference
1  [PMID:25482540]
  Authors
Schaefer CM, Lu R, Nesbitt NM, Schiebel J, Sampson NS, Kisker C.
  Title
FadA5 a thiolase from Mycobacterium tuberculosis: a steroid-binding pocket  reveals the potential for drug development against tuberculosis.
  Journal
Structure 23:21-33 (2015)
DOI:10.1016/j.str.2014.10.010
Reference
2  [PMID:19822655]
  Authors
Nesbitt NM, Yang X, Fontan P, Kolesnikova I, Smith I, Sampson NS, Dubnau E
  Title
A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol.
  Journal
Infect Immun 78:275-82 (2010)
DOI:10.1128/IAI.00893-09
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