KEGG   REACTION: R13746
Entry
R13746                      Reaction                               
Definition
5-Bromoindole + 2 Bromide + 2 FADH2 + 2 Oxygen + 2 H+ <=> 2,3,5-Tribromoindole + 2 FAD + 4 H2O
Equation
C23195 + 2 C01324 + 2 C01352 + 2 C00007 + 2 C00080 <=> C23196 + 2 C00016 + 4 C00001
Comment
two-step reaction
flavin-dependent halogenase
Enzyme
1.14.19.-
Pathway
rn00997  Biosynthesis of various other secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.-
     R13746  5-Bromoindole + 2 Bromide + 2 FADH2 + 2 Oxygen + 2 H+ <=> 2,3,5-Tribromoindole + 2 FAD + 4 H2O
Orthology
K29230  5-bromoindole 2,3-dibrominase [EC:1.14.19.-]
Reference
1  [PMID:35142504]
  Authors
Adak S, Lukowski AL, Schafer RJB, Moore BS.
  Title
From Tryptophan to Toxin: Nature's Convergent Biosynthetic Strategy to Aetokthonotoxin.
  Journal
J Am Chem Soc 144:2861-2866 (2022)
DOI:10.1021/jacs.1c12778
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