Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1: TC41_0345
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Entry
TC41_0345 CDS
T01821
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
aad
Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1
Pathway
aad00290
Valine, leucine and isoleucine biosynthesis
aad00620
Pyruvate metabolism
aad01100
Metabolic pathways
aad01110
Biosynthesis of secondary metabolites
aad01210
2-Oxocarboxylic acid metabolism
aad01230
Biosynthesis of amino acids
Module
aad_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
aad00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
TC41_0345 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
TC41_0345 (leuA)
Enzymes [BR:
aad01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
TC41_0345 (leuA)
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Motif
Pfam:
HMGL-like
IPMS_D2
LeuA_dimer
DUF3126
Motif
Other DBs
NCBI-ProteinID:
AEJ42312
UniProt:
F8IKC4
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All DBs
Position
328752..330476
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AA seq
574 aa
AA seq
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MKTREEEWMDVKHVNKYTRQYFLPPKPCFDWVHRDYLDHPPIWCSVDLRDGNQALIVPMN
LEEKLAYFQLLVEIGFKEIEVGFPAASDTEFEFVRTLIERDLVPDDVTIQVLTQSRDHII
ERTFEAIRGAKRAIVHLYNSTSVAQREQVFRADKDEIVNIAVTGAEQIRDLARTTPGNFF
FQYSPESFTGTELDFALEICNAVLDVWQPTPDRKVIINLPATVELSMPHVYASQIEYMGK
HLARRDAVILSVHPHNDRGTGVAAAELAMLAGAERLEGTLFGNGERTGNVDIVTLALNLY
SHGIDPGLDFSNLPAIQARVEALTKMQVSRRHPYAGELVFTAFSGSHQDAIAKGMKWREE
KSPEHWTVPYLPIDPKDIGREYEGDIIRINSQSGKGGIGYVLEQSHGFDLPPKMREQLGY
AVKRVSDREQKELSADEIAEIFMREFVNLGQPLDLVELTGTDAKGSHRVRATVVWQGETV
EIEGAGNGRLDALCHALEEGLGIRVANLTYKEHALEVGSGSRAVAYISVDDEEGNTHFGC
GVDTDIMEASAKALVSAVNRMLAHRPEIAVPVSK
NT seq
1725 nt
NT seq
+upstream
nt +downstream
nt
ttgaagacaagagaagaggagtggatggacgtgaagcatgtgaacaagtacacccgccag
tattttcttcccccgaaaccttgcttcgattgggtacatcgcgattacctcgatcacccg
ccgatctggtgcagcgtcgacttgcgcgacggaaatcaggcgctcatcgtcccgatgaat
ctcgaggagaagcttgcgtactttcagctgctcgtcgagatcggcttcaaggaaatcgag
gttggctttccggccgcatcagacacggagttcgagttcgttcggacgcttatcgagcgc
gatctcgtcccggacgacgtgaccatccaggtcctgacgcaatcgcgcgatcacatcatc
gagcgcacgtttgaagccattcgcggggccaagcgcgccattgtccatctctacaactcc
acgtccgtggcgcagcgcgaacaggtgttccgggcggacaaggacgagatcgtgaacatt
gccgtgaccggcgccgagcagatccgcgatctcgcccgcaccacaccaggcaacttcttc
ttccaatactcgccggagagcttcaccggcaccgaactcgacttcgcactcgagatctgc
aacgcagtgctcgatgtgtggcagcccacgccggatcgcaaggtcatcatcaacctgccg
gcgaccgtcgagctttccatgccgcacgtgtacgcgagccagatcgaatacatgggtaag
cacctggctcgccgcgacgccgtgattctgtccgtgcatccgcacaacgatcgcggcacg
ggtgtcgcggcggcggaactcgccatgctcgcgggcgcggagcggctcgagggcacgctg
tttgggaatggggagcgaacgggcaacgtggacatcgtcacgctcgcgctgaacctgtac
tcgcacggcatcgatccggggctcgacttctccaacctcccggccatccaggcccgcgtc
gaggccctcaccaagatgcaggtgagcaggcgtcacccgtacgcgggggaactcgtcttc
acggcgttttcgggatcgcatcaggatgccattgcgaagggcatgaagtggcgcgaggag
aagtcgcctgagcattggacggtcccgtatctgcccatcgatcccaaggatatcggccgc
gaatacgaaggggacatcatccgcatcaacagccaatccggcaagggtggcatcggctac
gtgctggagcagtcgcacggcttcgatctgccccccaagatgcgcgagcagctgggatat
gcggtcaagcgggtgtcggatcgcgagcagaaggagctgtcggcggacgagatcgccgaa
atcttcatgcgcgagtttgtgaaccttgggcagccgctcgatctcgtcgaactgacgggc
acggatgcgaagggatcgcaccgcgtgcgcgcgacggtggtctggcagggcgagacggtc
gagatcgaaggggccggcaatgggcggttggacgcgctgtgccatgcgctggaggagggg
cttgggatccgggtcgcgaatctcacgtacaaggagcatgcgctggaagtcgggtcggga
tcgcgagcggtggcgtacatcagcgtggacgacgaagaagggaatacgcatttcggatgc
ggcgtggatacggacattatggaggcgtcggcgaaggcgctggtgagcgcggtcaatcga
atgctcgcccacaggccggagatagccgttcctgtaagcaagtga
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