KEGG   Arvicola amphibius (Eurasian water vole): 119817089
Entry
119817089         CDS       T08327                                 
Symbol
Ryr2
Name
(RefSeq) ryanodine receptor 2
  KO
K04962  ryanodine receptor 2
Organism
aamp  Arvicola amphibius (Eurasian water vole)
Pathway
aamp04020  Calcium signaling pathway
aamp04024  cAMP signaling pathway
aamp04260  Cardiac muscle contraction
aamp04261  Adrenergic signaling in cardiomyocytes
aamp04371  Apelin signaling pathway
aamp04713  Circadian entrainment
aamp04911  Insulin secretion
aamp04921  Oxytocin signaling pathway
aamp04972  Pancreatic secretion
aamp05020  Prion disease
aamp05022  Pathways of neurodegeneration - multiple diseases
aamp05410  Hypertrophic cardiomyopathy
aamp05412  Arrhythmogenic right ventricular cardiomyopathy
aamp05414  Dilated cardiomyopathy
aamp05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:aamp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    119817089 (Ryr2)
   04020 Calcium signaling pathway
    119817089 (Ryr2)
   04024 cAMP signaling pathway
    119817089 (Ryr2)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    119817089 (Ryr2)
   04921 Oxytocin signaling pathway
    119817089 (Ryr2)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    119817089 (Ryr2)
   04261 Adrenergic signaling in cardiomyocytes
    119817089 (Ryr2)
  09154 Digestive system
   04972 Pancreatic secretion
    119817089 (Ryr2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    119817089 (Ryr2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05020 Prion disease
    119817089 (Ryr2)
   05022 Pathways of neurodegeneration - multiple diseases
    119817089 (Ryr2)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    119817089 (Ryr2)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    119817089 (Ryr2)
   05414 Dilated cardiomyopathy
    119817089 (Ryr2)
   05415 Diabetic cardiomyopathy
    119817089 (Ryr2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:aamp04040]
    119817089 (Ryr2)
   04990 Domain-containing proteins not elsewhere classified [BR:aamp04990]
    119817089 (Ryr2)
Ion channels [BR:aamp04040]
 Voltage-gated cation channels
  Ryanodine receptor
   119817089 (Ryr2)
Domain-containing proteins not elsewhere classified [BR:aamp04990]
 EF-hand domain-containing proteins
  Other EF-hand domain-containing proteins
   119817089 (Ryr2)
SSDB
Motif
Pfam: RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8
Other DBs
NCBI-GeneID: 119817089
NCBI-ProteinID: XP_038190214
LinkDB
Position
6:complement(115060140..115447856)
AA seq 4984 aa
MWIWLSDSGTLDLMIQFLKTCDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNS
KNVPPDLSICTFVLEQSLSVRALQEMLANTMEKSEGQVDVEKWKFMMKTAQGGGHRTLLY
GHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKV
RVGDDLILVSVSSERYLHLSYGNSSWHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLR
LLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPF
RLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFAFRSSKEKLDVGVRKEVDGMGTSEIK
YGDSICYIQHVDTGLWLTYQSVDVKSARMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRT
ARVIRSTVFLFNRFIRGLDALSKKAKAPTIDLPIESVSLSLQDLIGYFHPPDEHLEHEDK
QNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYE
LLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIK
SIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSM
RPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGG
NGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPV
QGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAACYEAVLPKEKLKVE
HSREYKQERTYTRDLLGPTVSLTQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVM
NKIELGWQYGPVRDDNKRQHPCLVEFGKLPEQERNYNLQMSLETLKTLLALGCHVGIADE
HAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQG
WTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHAARA
EVSSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDERAF
AFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDF
DVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRL
PQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFS
KTVAGGLPGAGLYGPKNDLEDYDVDSDFEVLMKTAHGHLVPDRLDKDKETPKPEFNNHKD
YAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYEYLMQTSTYYYSVRIFPG
QEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMS
PGQGRNNSNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQ
FELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISER
QGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLQFHYHTLRLYSAVCALGNHRVAH
ALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETK
SITLFPNENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKAKTIQM
LTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGVFHNEDLKHILQLIEPSVFKEA
ASPEEEGGAPEKDISAEDSKLEGIGEEEAKVGKRPKEGLLQMKLPEPVKLQMCLLLQYLC
DCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQIN
MLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGSNDLTIRGRLLSLVE
KVTYLKKKQAEKPVASDSRKPSSLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDG
IGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKV
FYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAM
FDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGL
QSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPA
LRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLDTEEEEDDTIHMGNAIMTFYAA
LIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGKVVEP
DMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMAL
ALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLL
SICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAAS
EEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSS
MDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQ
PLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVS
IDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPY
DTLTAKEKAKDREKAQDIFKFLQISGYAVSRGFKDLDLDTPSIEKRFAYSFLQQLIRYVD
EAHQYILEFDGGSRSKEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCTGGH
ASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLDSVKS
ALRAFLDNAAEDLEKTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPMLSSLFEHIGQH
QFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHL
DKHNVYSIYNTRSSRERAALSLPANVEDVCPNIPSLEKLMAEIIELAESGIRYTQMPHMM
EVVLPMLCSYMSRWWEHGPENHPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAW
MKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLI
LDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIFWSKSHNFKRE
EQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLP
IGLNICAPGDQELIALAKNRFSLKDTEEEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLP
NRTEDTSDPERTVERVLDIANVLFHLEQKSKYTEYTGRRYFSLGSTVEHPQRSKKAVWHK
LLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGA
EPAEEDEATKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEE
EVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGDTGPMVAATLKLGIAILNGG
NSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKV
LQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFY
WYYSGKDIIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLH
VFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNN
VEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSC
AETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYF
QPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELF
VNFCEDTIFEMQLAAQISESDLNERSANKEESEKERPEEQGPRMGFFSLLTIQSALFALR
YNVLTLVRTLSLKSLKKQMKRMKKMTVKDMVTAFFSSYWSVFVTLLHFVASVCRGFFRIV
SSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDEEEGERKSLESALPSEDLTDLKEL
TEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMTNPMPVPEVQEKFQEQKAKEEKE
EKEETKSEPEKAEGEDGEKEDKAKDDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQK
LLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELSARSSGDTAKVSTSLDS
SPHRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARK
LEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISEL
LGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMS
VLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFF
RKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDIT
FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHT
LQEHNLANYLFSVSVGFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYE
DQLN
NT seq 14955 nt   +upstreamnt  +downstreamnt
atgtggatatggctttcagattcaggtacattagatttaatgattcagttcctgaaaaca
tgtgatgatgaggtggttctgcagtgcactgcgaccgtccacaaggagcagcagaagcta
tgcttggcggcagaagggtttggcaacagactttgttttttggagtctacatccaattcc
aagaatgtgcccccggacctgtccatctgcacctttgtgctggagcagtctctgtcagtg
cgtgccctgcaggagatgctggccaacacgatggagaagtcagaagggcaggttgatgtg
gaaaaatggaagttcatgatgaagactgctcaaggtggaggccaccgcacactcctctat
ggacacgccatattgctacgccattcctacagtggtatgtatttgtgctgtctctccacc
tcccggtcttccactgacaaactggcctttgatgttggccttcaagaggacaccacaggg
gaggcttgctggtggaccatacatcctgcctctaagcagagatcagaaggagaaaaggtg
cgggttggagatgacctcatcttggtcagtgtgtcctctgaaaggtacttgcacttgtcc
tatggcaacagcagctggcatgtggacgctgccttccagcagaccctctggagcgtggcc
cccatcagctctggaagtgaagcagcccaagggtatcttattggtggcgatgttctccgg
ctgctacatggacacatggatgagtgtctcactgtcccttcaggagaacatggcgaagaa
cagcggagaacagttcattacgaaggtggtgccgtatcagttcacgcgcgctccctctgg
agactagagaccctaagagtcgcgtggagtggaagtcacataagatggggccagccattc
cgactgcggcatgtcacaacaggaaaatacttaagccttatggaagacaagaaccttctt
ctcatggacaaagaaaaggctgatgtaaaatcaactgcatttgccttccggtcttccaag
gaaaaattggatgtaggggtgagaaaagaagttgatggcatgggaacctcagaaatcaaa
tacggagactccatttgctatatacaacatgtggatacaggcctgtggctcacataccag
tcagtagatgtgaaatcagcacgaatgggatccatacagcgtaaggccattatgcaccat
gaaggccacatggatgatggcttgaacttatccagatcacagcatgaagagtcccgcaca
gcccgcgttatccggagcacagtgttcctcttcaatagattcataaggggcctggatgct
ctcagcaagaaagcaaaggcacccactattgacttgcccatcgagtctgtgagcctgagt
ttgcaggacctcatcggctacttccatccccctgatgagcacttggaacacgaggacaag
cagaacaggctgcgagccctgaagaataggcagaatctcttccaggaagagggaatgatc
aacttggttctggagtgcatagaccgcctgcacgtctacagcagtgcagcccactttgca
gatgtcgcagggagagaagcgggggagtcttggaaatccattctgaattctctgtacgag
ttgctggcggctctaattagaggaaatcgtaaaaactgtgctcaattttctggctccctc
gactggctgatcagcagactggaaagactggaagcgtcctctggcattctggaggtcctc
cactgcgtgttagtggaaagcccagaagctctgaatatcatcaaagaaggacatatcaaa
tccatcatctcacttttagacaagcatggaagaaaccacaaggtcctggacgtgttgtgc
tctctctgtgtttgccatggggttgctgtccgttccaaccagcatctcatctgtgacaat
ctgctgccaggacgagatctcttactgcagacccgtcttgtgaatcatgtcagcagcatg
aggcctaatatcttcctgggcgtcagtgaagggtcagcgcagtataagaagtggtactac
gagctcatggtggaccacactgaacccttcgtgacagcagaagctactcacctgcgagtg
ggctgggcttctactgaagggtattccccgtaccccggcgggggtgaagagtggggtggt
aatggcgttggtgatgacctcttctcctacgggttcgatggccttcacctctggtcaggt
tgtatagctcgaacggtgagctcacccaatcagcacttgttgagaactgacgatgtcatc
agttgctgtttagatctaagtgctccaagcatctcattccgcattaatggacaacctgtt
caaggaatgtttgagaacttcaatatcgatggcctattctttccggttgttagtttctct
gcaggaataaaggttcgctttttacttggggggagacatggagaattcaagttcctccct
ccacctggctatgcagcttgctatgaagctgttctgccgaaagagaaattgaaagtagag
cacagccgagaatataagcaagaaaggacatacacacgagatttgctggggcccacagtg
tccctgacccaagctgccttcacacccgttcctgtggacaccagccagattgtgttgcct
cctcacctggaaaggataagagaaaagctggcagagaatatccatgagctctgggttatg
aataaaattgagcttggctggcagtatggtccggttagagatgacaacaagagacagcat
ccgtgtctggtggagttcggaaaactaccagaacaggaacgcaactacaatttgcagatg
tcgcttgaaactctcaagactttgctggcattaggatgtcacgtgggtatagcagatgag
cacgctgaagagaaggtgaagaagatgaagctgcccaagaattaccagctgaccagtgga
tacaagcctgcccccatggatctgagctttataaaactcaccccctctcaggaagcaatg
gtggacaagttggccgaaaatgctcacaacgtgtgggcccgggatcgaatccggcagggc
tggacttacggcatccagcaggatgtgaagaacagaagaaaccctcgtcttgttccctat
actctcctggatgatcgaaccaagaagtcaaacaaagacagtctccgagaggcggttcgc
acactgctgggctatggctaccacctggaagctcccgatcaggaccacgccgcgagagcc
gaggtgagcagcggcactggggagaggttccgcatcttcagggccgagaagacctacgca
gtgaaggctgggcgctggtactttgaatttgaggcagtcacagctggagacatgcgggtg
ggctggagcaggccaggctgccagcccgatctagagctgggttctgatgaacgtgccttt
gcttttgatggctttaaggcccagcggtggcaccagggcaatgaacactacgggcgctct
tggcaagcaggtgatgtcgtgggctgtatggttgatatgaacgaacataccatgatgttc
actctgaatggcgagatcctgctggatgactcaggctccgagctggctttcaaggacttt
gacgttggtgatggcttcatccctgtgtgtagccttggggtggcacaagtaggcaggatg
aacttcgggaaggacgtcagcactttgaaatatttcaccatctgtggcttacaagaaggc
tatgagccatttgccgttaacacaaacagggacatcaccatgtggctgagcaagcgactt
cctcagttcctccaggtcccatcaaaccatgaacatatcgaggtaacaagaatagatggc
accatagacagttctccgtgtctgaaagtcactcagaagtcctttggttctcagaacagc
aacactgacatcatgttttatcgcctgagcatgcccatcgagtgtgctgaggtcttctcc
aagacggtggcaggagggctccctggtgcaggcctctatgggcccaagaatgatctggaa
gattatgatgtggactctgactttgaggttctgatgaagacagctcacggtcatttggtg
cctgaccgccttgacaaggacaaagaaaccccgaagccagagtttaataaccataaagat
tatgctcaggaaaagccttcacgtctaaagcaaagattcctgcttagaaggacgaagcca
gattatagcacaagccattctgcaagactcactgaagatgtgcttgctgatgaccgggat
gactatgagtatctgatgcagacatccacgtactattactcagtgaggatctttcctgga
caagagcctgctaacgtgtgggtgggctggatcacatctgacttccaccagtacgacacg
ggctttgatttggacagagtgcgcacagtgaccgtcactctaggagacgaaaaaggaaaa
gtacacgagagcatcaaacgcagcaactgctatatggtgtgtgcaggagagagcatgagc
cctgggcaaggacgaaataacagcaatggtctggagattggctgcgtagtggatgctgcc
agcgggctgctcacattcattgccaacggcaaggagctaagtacttactatcaggtggag
ccaagcacaaagttatttcctgcagtttttgcacaagctacaagtcccaatgtcttccag
tttgaattgggcagaataaagaatgtgatgcctctctcagcgggattgtttaaaagtgaa
cacaaaaaccccgtgccccagtgtcccccacgtctgcacgtacagttcctgtcacatgtt
ctgtggagccggatgcccaaccagttcttgaaggtggatgtctctcgaatcagtgaacgc
caaggctggctggtgcagtgtctggatcctctgcagttcatgtccctgcatatccctgag
gaaaacaggtctgttgacatcctagagctgacagagcaggaagagttgctccagtttcac
tatcacaccctccgcctctactccgctgtctgtgccctcgggaatcaccgggtggcccat
gcgctctgcagccacgtggatgaacctcagctgctctatgccatcgagaacaagtacatg
cctggcctgctgcgtgctggctactatgacctgctcattgacatccacctcagctcctat
gccaccgccaggctcatgatgaacaatgagttcattgtcccgatgacagaggagacaaag
agcattaccctcttccccaatgagaacaagaaacatggtctcccaggcatcggcctcagc
acgtctctccggcctcggatgcagttttcctcccctagtttcgtgagcattagcaatgaa
tgttatcagtacagtcccgagtttccactggacatcctcaaggccaagaccatccagatg
ctcacggaagcagtgaaggagggcagcctccatgctcgggaccctgtgggtgggaccacc
gagttcctgtttgtgcctctcatcaagctcttctacaccctgctcattatgggtgtcttt
cacaatgaggatctgaaacacatcctacagttgattgagcccagtgtgtttaaggaagct
gcctctccagaggaggaaggaggagccccagagaaggatatcagtgcagaagactctaag
ctggaaggaataggtgaagaagaagccaaggtgggcaagaggcccaaggaaggcctgctc
cagatgaaactccctgagccagttaaactacagatgtgcctcttgcttcagtacctctgt
gactgccaggttcggcaccggatagaagccatagtagccttttcagatgactttgtagct
aagcttcaagacaatcaacggttcagatataatgaagttatgcaagccttaaacatgtct
gctgcactcactgcacggaaaacgaaggagttccggtcaccaccgcaagagcagattaac
atgcttctcaattttaaggatgataaaagtgaatgtccttgtcctgaagaaatccgagac
caactgctggatttccacgaggatctgatgactcactgtggaattgagctggatgaagat
ggatccctggatggaagcaatgacttaacaatcagaggacgtctgctgtccctggtagaa
aaggtgacctacctgaagaagaaacaagctgaaaaaccagttgcaagtgactccagaaag
ccctccagtctccagcaattgatttctgagactatggtgcggtgggctcaagagtctgtc
atcgaggaccctgagctggtgagggccatgtttgtgttgctgcatcgacagtatgatggc
attgggggtctagtccgggcactgccgaagacctacactatcaatggtgtctctgtggag
gataccatcaatctgcttgcatcgcttggtcagatccgatctctgctgagtgtgaggatg
ggcaaagaagaggagaagctaatgatccgtggattgggggatatcatgaataacaaagtg
ttttatcagcaccccaatcttatgagggcccttggaatgcatgaaacagtgatggaagtc
atggtgaatgtccttggaggcggggagtccaaggaaatcaccttccccaagatggtggcc
aactgttgccgttttctctgttacttctgtcgtattagtaggcagaatcagaaagcaatg
tttgatcatctcagttatttactggaaaacagcagtgtcggtcttgcttcaccagctatg
agagggtcaactcccctggacgtggctgcagcttcggtcatggacaacaatgaacttgcc
cttgctctccgggagccagatctggagaaggtagttcgttatctggccggctgtgggctg
cagagctgccagatgctggtgtctaaaggttaccccgacattgggtggaatccagttgaa
ggagagagataccttgactttctcagatttgctgtcttctgtaacggggagagtgtggaa
gagaacgcaaacgtcgtggtgaggttgctcatccggagacccgagtgctttggtcctgcc
ttgagaggggaaggtggcaatggcctccttgcagccatggaagaggccataaaaatagct
gaggatccttctagagatggtccctccccaaccagtggatccagcaaaacccttgataca
gaagaggaggaagatgacaccatccacatggggaatgccattatgaccttctatgcagct
ttgattgacttgctcggtcgctgtgctcctgaaatgcatttgattcatgctggaaaggga
gaagccattcgaatcaggtcgattttgcgatccctgattccactgggagacttggtgggc
gtaatcagcattgcatttcaaatgccgacaatagccaaagatgggaaggtggtggagcct
gacatgtccgcggggttttgcccagatcacaaggcagccatggttttgttccttgacagg
gtctatggaattgaggtgcaagatttcctcctccatctccttgaggttggctttctgcca
gatctccgagctgctgcctctctagacacggctgcactaagtgctacagacatggccttg
gccctcaatcggtacctttgcacagctgtcctgcctttgttaacgagatgtgctcccctg
tttgctggaacagagcaccatgcttccctcattgactctctgctgcatactgtgtataga
ctgtctaagggatgttccctcaccaaagctcagcgcgactccatagaagtgtgcctgctc
tctatatgtggccaactgcgaccttctatgatgcaacacctactcagaaggctggtattt
gacgttccactgttgaatgagcatgcaaagatgcctcttaagcttctgacaaatcattat
gaaagatgctggaaatattactgcctgcctggaggatggggcaattttggtgctgcctca
gaagaagaacttcatttatcaagaaagttattttggggcatttttgatgctttgtctcaa
aagaaatatgaacaagaacttttcaaactggccctgccttgcctgagtgcagttgcggga
gctttacctccagactacatggagtcaaactatgtcagtatgatggaaaaacagtcatcc
atggattctgaagggaactttaacccacaacctgttgatacctcaaacattacaattcct
gagaagttggaatacttcattaacaaatatgcagaacattcccatgataaatggtcaatg
gacaagttggcgaatggatggatttatggggaaatatattcagactcttctaaggtccag
ccattaatgaagccatataaactattgtctgaaaaggaaaaagaaatatatcgctggccc
atcaaggagtctttaaaaacgatgctggcttggggttggagaattgagagaacacgagag
ggagatagtatggctctttataaccggactcgacgcatttctcagacaagccaggtgtct
atagatgctgcgcatgggtatagccctcgtgctattgacatgagcaacgttacactatcc
cgagacctgcatgctatggcggaaatgatggctgaaaactaccacaacatatgggccaag
aaaaagaaaatggagctggaatccaaaggaggaggaaaccatcccctgctggtgccctat
gacacactgacagccaaagagaaagccaaggacagagagaaggctcaggatatcttcaag
ttcctacagatcagtggttatgctgtatccagagggttcaaggacctggatctggacaca
ccttccattgagaagcgatttgcctatagtttcctgcagcagctgatccgctatgtggac
gaggctcatcagtacatcctggagtttgatggcggcagcagaagcaaagaacatttcccg
tacgagcaagaaatcaagttctttgccaaagtcgttcttccattaatcgatcagtatttc
aaaaaccaccgcctgtacttcttgtctgcggcaagcaggcctctctgcactggaggacac
gcatccaacaaagagaaggagatggtgacgagcctgttctgcaaacttggagttcttgtc
aggcataggatctcactgtttgggaatgatgctacctcaattgtgaactgtcttcatatt
ctgggtcagactttggatgcaagaactgtgatgaagacgggcctggacagtgtgaaaagt
gctctcagggcctttctggacaacgcagcagaggatctggaaaagacaatggaaaacctt
aagcagggccagtttacccacacccggagccagcccaaaggggtgactcagatcatcaac
tacaccacggtggcactgttgcccatgctctcgtccctgtttgaacacattggccagcat
cagtttggagaagatctgatattggaggatgtgcaggtgtcttgttacagaattctgacc
agcttgtatgccttgggaacaagcaagagcatctacgtggaaaggcagagatctgcactc
ggagaatgcctagctgcctttgctggtgccttccctatagcctttttggaaacccacctg
gacaaacataatgtttactccatctacaacaccaggtcttcacgggagagagcagctctc
agtttaccagcaaatgtggaggatgtctgcccaaatataccatccctggagaagctcatg
gctgagatcatagagctggcagagtcaggtatccgctacactcagatgccacacatgatg
gaggttgtactgcccatgctgtgcagctacatgtcacgatggtgggagcacggtcctgag
aaccatccagagagagccgagatgtgctgtacagctctcaactcagaacacatgaacaca
ctgctgggcaacattctcaaaatcatctacaacaacctggggatcgacgaaggagcctgg
atgaaacgcttagcagtgttttcgcagcctatcatcaacaaggtgaaaccccagctcttg
aaaactcacttcttgcccttgatggagaagctaaagaaaaaggctgccatggtagtgtct
gaggaagaccacctaaaagccgaggccagaggggacatgtccgaggctgagctgctcatt
ttggatgagttcaccacgctggccagggatctctatgccttctacccactcttgattcga
tttgtggactataacagagcaaaatggctgaaggagcccaacccagaagcagaggagctc
tttcgaatggtggctgaagtcttcatcttctggtccaaatcccataatttcaaaagagaa
gaacagaactttgtggtgcagaatgaaatcaacaacatgtccttcctcatcactgatacc
aagtctaagatgtccaaggcagccgtttctgaccaagagaggaagaaaatgaagcgcaaa
ggggaccgctattctatgcagacatcgctgattgtggcagctctgaagcgactgctgccc
attgggctgaacatctgtgcccccggggaccaggagctcattgctctggccaaaaatcga
tttagcttgaaagacaccgaggaggaagtacgagatataatccgcagtaatatacaccta
caaggcaagttggaagatcctgcaatcaggtggcaaatggctctctacaaagacctgcca
aacaggacggaagacacctcagacccagagaggacagtggagcgtgtcttggatatagca
aatgtactttttcatcttgaacagaaatctaagtatactgagtatactggccggagatat
ttcagtctgggaagtacagtggaacatcctcagagatcgaagaaggctgtatggcataaa
ctactctctaagcagaggaaaagagccgtcgtcgcctgcttccggatggcccccttgtac
aatctgccaaggcatcgggctgtcaatctttttcttcagggatatgaaaagtcgtggatt
gaaacggaggagcattactttgaggataaattgattgaagatttagcgaagccaggtgct
gaacctgcagaagaagacgaagccacgaaaagagtagatcctctccaccagctcattctt
ctcttcagccgcacggccttaacagagaaatgcaaactggaggaagattttctatatatg
gcatatgcagatattatggcaaagagttgtcacgatgaggaagacgatgacggtgaagaa
gaagtgaagagctttgaagaaaaagaaatggagaagcagaaacttctctaccagcaagcc
agactgcacgaccgtggggcagcggagatggtgcttcagaccatcagtgccagcaaagga
gacactggaccaatggtggctgcaactttgaaactgggcattgctattttaaatggtggg
aactccacggtacagcagaagatgctggactacctgaaggaaaagaaggatgtaggcttc
ttccagagcctggcaggcctcatgcagtcttgcagtgtcctcgacctgaatgcctttgag
agacaaaacaaagcggaaggacttgggatggtgactgaggaaggatcaggagagaaggta
ctgcaggatgatgagttcacctgtgacctcttccgattcctgcagctgctctgtgaggga
cacaactcagattttcaaaattacctgagaactcagaccggcaacaatacgactgtcaat
atcatcatctctaccgtggactaccttctccgcgtgcaggagtccattagtgatttctat
tggtactactctgggaaagacatcattgatgagcagggccagcgcaacttctccaaagcc
atccaagtggcgaagcaggtgttcaacactctcacggagtacatccagggtccttgtact
ggcaaccagcagagcctggcacacagcaggctgtgggatgctgttgtgggcttccttcat
gtgtttgcccacatgcagatgaagctgtctcaggattccagccaaatcgagctcttgaaa
gaactgatggatctccagaaggacatggtggttatgctactgtccatgctagaaggtaac
gttgtgaacggaaccataggcaaacagatggtggacatgcttgtggagtcttccaacaac
gtggagatgatcctcaagttctttgatatgttcttgaagctaaaggacttgacatcctcg
gacacatttaaggagtacgacccagacggaaaaggggtcatttccaagagagacttccac
aaagccatggaaagccacaagcactacacacaatcagagaccgagtttctgctgtcgtgt
gccgagacagacgaaaacgaaaccctggactatgaggagtttgtcaaaaggttccatgag
cctgcgaaggacattggcttcaatgttgctgtcctgttgaccaacctctcggagcacatg
cccaatgacacgaggctgcagaccttcttggagttagcagagagtgtcctcaactacttc
caacctttcctgggtcgcattgagatcatgggcagtgccaagcgcatcgagagggtctac
tttgagatcagcgagtccagccgaacccagtgggagaagccacaggtcaaggagtccaaa
agacagttcatattcgatgtggtcaatgagggtggggagaaggagaagatggagctcttt
gtgaacttctgcgaggacaccatcttcgagatgcagctggcagctcagatctcagagtct
gatctaaacgagaggtcagccaataaagaagagagtgagaaagagaggcctgaagagcag
ggcccacggatgggcttcttctccctcctcaccatccagtcggccctgtttgctctcagg
tacaacgtcctaaccctggttaggacactcagcctgaagagcctaaaaaagcagatgaag
agaatgaagaagatgacggtgaaggacatggtcactgccttcttctcgtcctactggagt
gtctttgtgaccctcttacacttcgtggccagtgtctgtaggggcttttttcgcatcgtc
tccagcctgctgcttggggggagcctggtggaaggtgctaagaaaatcaaagtggccgag
cttctagccaacatgccagaccccactcaggatgaggtgcgaggagatgaagaagaggga
gagaggaagtctttggagtccgctctgccctctgaagatctgacagacttaaaggaactg
acagaggaaagtgaccttctctcggacatatttggcttggatctgaagagggaaggcggg
cagtacaaactgattcctcacaacccaaatgccggccttagtgacctgatgaccaacccc
atgcctgtccctgaggtacaggaaaagtttcaggagcagaaggcaaaagaagagaaggaa
gaaaaagaagaaaccaagtctgaacctgagaaggctgagggggaagatggagaaaaagaa
gacaaagccaaagatgataaaggcaagcagaagttgagacagcttcacacacatcggtat
ggggaacctgaggtgccagagtcagcattctggaagaaaatcatagcctatcagcagaag
ctgctgaactattttgctcgcaacttttacaacatgagaatgctggccttatttgtcgcc
tttgccatcaatttcatcctgctcttctacaaggtctccacttcttctgtggttgaagga
aaggagctgtctgcccgaagctctggtgacactgccaaagtttccaccagcctggacagc
agcccacacagaatcatagcggtgcactacgtcctggaggagagcagcggctacatggaa
cccacgctgcgcatcttagccatcttgcacaccgtcatctctttcttttgcatcattgga
tactactgcctgaaagtccccttggtgatttttaagcgggagaaggaagtggcacgtaag
ctggagtttgacgggctttacatcacagagcagccttcggaggatgatatcaaaggccag
tgggaccgactggtgatcaacacacagtcatttcccaataactactgggataaatttgtt
aaaagaaaggtgatggataagtatggagagttctatgggcgagacagaatcagtgagtta
ctgggcatggataaggctgccctggatttcagcgacgcgagagagaagaagaagcccaag
aaggacagctccttgtctgctgtactgaactctattgatgtgaagtaccagatgtggaag
ctgggagtcgtgttcacagacaactccttcctgtacctagcctggtatatgaccatgtcc
gttcttggacactataacaactttttttttgctgctcacctccttgacatcgcgatggga
ttcaagaccttgagaaccatcctgtcctcggtcacccacaatggcaaacagctcgtgttg
actgtcggcttgttagctgtcgttgtgtacctgtacactgtcgtggcattcaatttcttc
cggaagttctataacaaaagtgaagatggtgatacgccagacatgaaatgcgatgacatg
ctgacgtgttacatgttccacatgtacgtgggcgtccgtgctggagggggcattggtgat
gaaattgaagacccagcgggagatgagtatgagatctaccgcatcatctttgacatcacg
ttcttcttctttgtgatcgtcatccttttggccatcatacaaggtttgatcatcgatgct
tttggagaactcagagaccaacaagagcaagtcaaggaagacatggagactaagtgcttc
atctgcgggataggcaatgactactttgatacggtgcctcacggctttgaaacacatacg
ctacaggaacacaacctggccaactaccttttctctgtctctgtaggttttttcctgatg
tatctcataaacaaggatgaaacggaacacacgggacaggaatcttatgtctggaagatg
tatcaggagaggtgttgggagtttttcccagcaggggactgtttccggaaacagtatgaa
gaccagttgaattaa

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