KEGG   Arvicola amphibius (Eurasian water vole): 119818643
Entry
119818643         CDS       T08327                                 
Symbol
Akt1
Name
(RefSeq) RAC-alpha serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
aamp  Arvicola amphibius (Eurasian water vole)
Pathway
aamp01521  EGFR tyrosine kinase inhibitor resistance
aamp01522  Endocrine resistance
aamp01524  Platinum drug resistance
aamp04010  MAPK signaling pathway
aamp04012  ErbB signaling pathway
aamp04014  Ras signaling pathway
aamp04015  Rap1 signaling pathway
aamp04022  cGMP-PKG signaling pathway
aamp04024  cAMP signaling pathway
aamp04062  Chemokine signaling pathway
aamp04066  HIF-1 signaling pathway
aamp04068  FoxO signaling pathway
aamp04071  Sphingolipid signaling pathway
aamp04072  Phospholipase D signaling pathway
aamp04140  Autophagy - animal
aamp04150  mTOR signaling pathway
aamp04151  PI3K-Akt signaling pathway
aamp04152  AMPK signaling pathway
aamp04210  Apoptosis
aamp04211  Longevity regulating pathway
aamp04213  Longevity regulating pathway - multiple species
aamp04218  Cellular senescence
aamp04261  Adrenergic signaling in cardiomyocytes
aamp04370  VEGF signaling pathway
aamp04371  Apelin signaling pathway
aamp04380  Osteoclast differentiation
aamp04510  Focal adhesion
aamp04550  Signaling pathways regulating pluripotency of stem cells
aamp04611  Platelet activation
aamp04613  Neutrophil extracellular trap formation
aamp04620  Toll-like receptor signaling pathway
aamp04625  C-type lectin receptor signaling pathway
aamp04630  JAK-STAT signaling pathway
aamp04660  T cell receptor signaling pathway
aamp04662  B cell receptor signaling pathway
aamp04664  Fc epsilon RI signaling pathway
aamp04666  Fc gamma R-mediated phagocytosis
aamp04668  TNF signaling pathway
aamp04722  Neurotrophin signaling pathway
aamp04725  Cholinergic synapse
aamp04728  Dopaminergic synapse
aamp04810  Regulation of actin cytoskeleton
aamp04910  Insulin signaling pathway
aamp04914  Progesterone-mediated oocyte maturation
aamp04915  Estrogen signaling pathway
aamp04917  Prolactin signaling pathway
aamp04919  Thyroid hormone signaling pathway
aamp04920  Adipocytokine signaling pathway
aamp04922  Glucagon signaling pathway
aamp04923  Regulation of lipolysis in adipocytes
aamp04926  Relaxin signaling pathway
aamp04929  GnRH secretion
aamp04931  Insulin resistance
aamp04932  Non-alcoholic fatty liver disease
aamp04933  AGE-RAGE signaling pathway in diabetic complications
aamp04935  Growth hormone synthesis, secretion and action
aamp04936  Alcoholic liver disease
aamp04973  Carbohydrate digestion and absorption
aamp05010  Alzheimer disease
aamp05017  Spinocerebellar ataxia
aamp05132  Salmonella infection
aamp05135  Yersinia infection
aamp05142  Chagas disease
aamp05145  Toxoplasmosis
aamp05152  Tuberculosis
aamp05160  Hepatitis C
aamp05161  Hepatitis B
aamp05162  Measles
aamp05163  Human cytomegalovirus infection
aamp05164  Influenza A
aamp05165  Human papillomavirus infection
aamp05166  Human T-cell leukemia virus 1 infection
aamp05167  Kaposi sarcoma-associated herpesvirus infection
aamp05168  Herpes simplex virus 1 infection
aamp05169  Epstein-Barr virus infection
aamp05170  Human immunodeficiency virus 1 infection
aamp05200  Pathways in cancer
aamp05205  Proteoglycans in cancer
aamp05207  Chemical carcinogenesis - receptor activation
aamp05208  Chemical carcinogenesis - reactive oxygen species
aamp05210  Colorectal cancer
aamp05211  Renal cell carcinoma
aamp05212  Pancreatic cancer
aamp05213  Endometrial cancer
aamp05214  Glioma
aamp05215  Prostate cancer
aamp05218  Melanoma
aamp05220  Chronic myeloid leukemia
aamp05221  Acute myeloid leukemia
aamp05222  Small cell lung cancer
aamp05223  Non-small cell lung cancer
aamp05224  Breast cancer
aamp05225  Hepatocellular carcinoma
aamp05226  Gastric cancer
aamp05230  Central carbon metabolism in cancer
aamp05231  Choline metabolism in cancer
aamp05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
aamp05415  Diabetic cardiomyopathy
aamp05417  Lipid and atherosclerosis
aamp05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:aamp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    119818643 (Akt1)
   04012 ErbB signaling pathway
    119818643 (Akt1)
   04014 Ras signaling pathway
    119818643 (Akt1)
   04015 Rap1 signaling pathway
    119818643 (Akt1)
   04370 VEGF signaling pathway
    119818643 (Akt1)
   04371 Apelin signaling pathway
    119818643 (Akt1)
   04630 JAK-STAT signaling pathway
    119818643 (Akt1)
   04668 TNF signaling pathway
    119818643 (Akt1)
   04066 HIF-1 signaling pathway
    119818643 (Akt1)
   04068 FoxO signaling pathway
    119818643 (Akt1)
   04072 Phospholipase D signaling pathway
    119818643 (Akt1)
   04071 Sphingolipid signaling pathway
    119818643 (Akt1)
   04024 cAMP signaling pathway
    119818643 (Akt1)
   04022 cGMP-PKG signaling pathway
    119818643 (Akt1)
   04151 PI3K-Akt signaling pathway
    119818643 (Akt1)
   04152 AMPK signaling pathway
    119818643 (Akt1)
   04150 mTOR signaling pathway
    119818643 (Akt1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    119818643 (Akt1)
  09143 Cell growth and death
   04210 Apoptosis
    119818643 (Akt1)
   04218 Cellular senescence
    119818643 (Akt1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    119818643 (Akt1)
   04550 Signaling pathways regulating pluripotency of stem cells
    119818643 (Akt1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    119818643 (Akt1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    119818643 (Akt1)
   04613 Neutrophil extracellular trap formation
    119818643 (Akt1)
   04620 Toll-like receptor signaling pathway
    119818643 (Akt1)
   04625 C-type lectin receptor signaling pathway
    119818643 (Akt1)
   04660 T cell receptor signaling pathway
    119818643 (Akt1)
   04662 B cell receptor signaling pathway
    119818643 (Akt1)
   04664 Fc epsilon RI signaling pathway
    119818643 (Akt1)
   04666 Fc gamma R-mediated phagocytosis
    119818643 (Akt1)
   04062 Chemokine signaling pathway
    119818643 (Akt1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    119818643 (Akt1)
   04922 Glucagon signaling pathway
    119818643 (Akt1)
   04923 Regulation of lipolysis in adipocytes
    119818643 (Akt1)
   04920 Adipocytokine signaling pathway
    119818643 (Akt1)
   04929 GnRH secretion
    119818643 (Akt1)
   04915 Estrogen signaling pathway
    119818643 (Akt1)
   04914 Progesterone-mediated oocyte maturation
    119818643 (Akt1)
   04917 Prolactin signaling pathway
    119818643 (Akt1)
   04926 Relaxin signaling pathway
    119818643 (Akt1)
   04935 Growth hormone synthesis, secretion and action
    119818643 (Akt1)
   04919 Thyroid hormone signaling pathway
    119818643 (Akt1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    119818643 (Akt1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    119818643 (Akt1)
  09156 Nervous system
   04725 Cholinergic synapse
    119818643 (Akt1)
   04728 Dopaminergic synapse
    119818643 (Akt1)
   04722 Neurotrophin signaling pathway
    119818643 (Akt1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    119818643 (Akt1)
  09149 Aging
   04211 Longevity regulating pathway
    119818643 (Akt1)
   04213 Longevity regulating pathway - multiple species
    119818643 (Akt1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119818643 (Akt1)
   05205 Proteoglycans in cancer
    119818643 (Akt1)
   05207 Chemical carcinogenesis - receptor activation
    119818643 (Akt1)
   05208 Chemical carcinogenesis - reactive oxygen species
    119818643 (Akt1)
   05230 Central carbon metabolism in cancer
    119818643 (Akt1)
   05231 Choline metabolism in cancer
    119818643 (Akt1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    119818643 (Akt1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    119818643 (Akt1)
   05212 Pancreatic cancer
    119818643 (Akt1)
   05225 Hepatocellular carcinoma
    119818643 (Akt1)
   05226 Gastric cancer
    119818643 (Akt1)
   05214 Glioma
    119818643 (Akt1)
   05221 Acute myeloid leukemia
    119818643 (Akt1)
   05220 Chronic myeloid leukemia
    119818643 (Akt1)
   05218 Melanoma
    119818643 (Akt1)
   05211 Renal cell carcinoma
    119818643 (Akt1)
   05215 Prostate cancer
    119818643 (Akt1)
   05213 Endometrial cancer
    119818643 (Akt1)
   05224 Breast cancer
    119818643 (Akt1)
   05222 Small cell lung cancer
    119818643 (Akt1)
   05223 Non-small cell lung cancer
    119818643 (Akt1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    119818643 (Akt1)
   05170 Human immunodeficiency virus 1 infection
    119818643 (Akt1)
   05161 Hepatitis B
    119818643 (Akt1)
   05160 Hepatitis C
    119818643 (Akt1)
   05164 Influenza A
    119818643 (Akt1)
   05162 Measles
    119818643 (Akt1)
   05168 Herpes simplex virus 1 infection
    119818643 (Akt1)
   05163 Human cytomegalovirus infection
    119818643 (Akt1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    119818643 (Akt1)
   05169 Epstein-Barr virus infection
    119818643 (Akt1)
   05165 Human papillomavirus infection
    119818643 (Akt1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    119818643 (Akt1)
   05135 Yersinia infection
    119818643 (Akt1)
   05152 Tuberculosis
    119818643 (Akt1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    119818643 (Akt1)
   05142 Chagas disease
    119818643 (Akt1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    119818643 (Akt1)
   05017 Spinocerebellar ataxia
    119818643 (Akt1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    119818643 (Akt1)
   05418 Fluid shear stress and atherosclerosis
    119818643 (Akt1)
   05415 Diabetic cardiomyopathy
    119818643 (Akt1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    119818643 (Akt1)
   04932 Non-alcoholic fatty liver disease
    119818643 (Akt1)
   04931 Insulin resistance
    119818643 (Akt1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    119818643 (Akt1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    119818643 (Akt1)
   01524 Platinum drug resistance
    119818643 (Akt1)
   01522 Endocrine resistance
    119818643 (Akt1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:aamp01001]
    119818643 (Akt1)
Enzymes [BR:aamp01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     119818643 (Akt1)
Protein kinases [BR:aamp01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   119818643 (Akt1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 PH_11 Seadorna_VP7
Other DBs
NCBI-GeneID: 119818643
NCBI-ProteinID: XP_038192227
LinkDB
Position
7:68387600..68408415
AA seq 480 aa
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEETMDF
RSGSPSDNSGAEDMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
NT seq 1443 nt   +upstreamnt  +downstreamnt
atgaacgacgtagccattgtgaaggagggctggctacacaaacgaggggaatacattaaa
acctggcggccacgctacttcctcctcaagaatgacggcacctttattggctacaaggaa
cggcctcaggatgtggagcagcgcgagtcccccctcaacaacttctcagtggcacaatgc
cagctgatgaagacagagcggccaaggcccaacaccttcatcatccgctgcctgcagtgg
accacagtcattgagcgcaccttccatgtggaaacgcctgaggagcgggaagagtggacc
accgccatccagactgtggctgatggactcaagaggcaggaggaagagacgatggacttc
cgatcaggttctcccagtgacaactcaggggctgaggacatggaggtgtccctggcgaag
cccaagcaccgtgtgaccatgaacgagtttgagtacctaaagctactgggcaagggtacc
tttgggaaggtgatcctggtgaaggagaaggccacaggccgctactatgccatgaagatt
ctcaagaaggaggtcatcgttgccaaggatgaggttgcccacacactgactgagaaccgt
gtcctgcagaactccaggcatcctttccttacagccctgaagtactcattccagacccat
gaccgcctctgctttgtcatggaatatgccaatgggggcgagctcttcttccacctgtct
cgtgagcgtgtgttttctgaggaccgggcccgcttctatggtgcggaaattgtgtcggcc
ttggactatctgcactccgagaagaacgtggtataccgggaccttaagctggagaacctc
atgctggacaaggacgggcacatcaagataacagactttgggctgtgcaaggagggtatc
aaggatggtgccactatgaagaccttctgtggaacccctgagtacctggcccctgaggtg
ctggaggacaacgactatggccgtgcggtggattggtgggggctgggcgtggtcatgtat
gagatgatgtgtggccgcctgcccttctacaaccaggaccacgagaagctgttcgagctt
atcctcatggaggagatccgcttcccacgtacacttggccctgaggccaagtccctgctc
tctgggttgctcaagaaggaccccacacagaggcttggcgggggctctgaggatgccaag
gagatcatgcagcatcgcttctttgccaacatcgtgtggcaggatgtatatgagaagaag
ctgagcccacctttcaagccccaggtcacctctgagactgacaccaggtattttgatgag
gagttcacagcccagatgatcactatcacaccgcctgatcaagatgacagcatggagtgt
gtcgacagcgagcggaggccacactttccccagttttcctactcagccagtggcacagcc
tga

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