KEGG   Arvicola amphibius (Eurasian water vole): 119824882
Entry
119824882         CDS       T08327                                 
Symbol
Plcb3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
aamp  Arvicola amphibius (Eurasian water vole)
Pathway
aamp00562  Inositol phosphate metabolism
aamp01100  Metabolic pathways
aamp04015  Rap1 signaling pathway
aamp04020  Calcium signaling pathway
aamp04022  cGMP-PKG signaling pathway
aamp04062  Chemokine signaling pathway
aamp04070  Phosphatidylinositol signaling system
aamp04071  Sphingolipid signaling pathway
aamp04072  Phospholipase D signaling pathway
aamp04081  Hormone signaling
aamp04082  Neuroactive ligand signaling
aamp04261  Adrenergic signaling in cardiomyocytes
aamp04270  Vascular smooth muscle contraction
aamp04310  Wnt signaling pathway
aamp04371  Apelin signaling pathway
aamp04540  Gap junction
aamp04611  Platelet activation
aamp04613  Neutrophil extracellular trap formation
aamp04621  NOD-like receptor signaling pathway
aamp04713  Circadian entrainment
aamp04720  Long-term potentiation
aamp04723  Retrograde endocannabinoid signaling
aamp04724  Glutamatergic synapse
aamp04725  Cholinergic synapse
aamp04726  Serotonergic synapse
aamp04728  Dopaminergic synapse
aamp04730  Long-term depression
aamp04742  Taste transduction
aamp04750  Inflammatory mediator regulation of TRP channels
aamp04911  Insulin secretion
aamp04912  GnRH signaling pathway
aamp04915  Estrogen signaling pathway
aamp04916  Melanogenesis
aamp04918  Thyroid hormone synthesis
aamp04919  Thyroid hormone signaling pathway
aamp04921  Oxytocin signaling pathway
aamp04922  Glucagon signaling pathway
aamp04924  Renin secretion
aamp04925  Aldosterone synthesis and secretion
aamp04926  Relaxin signaling pathway
aamp04927  Cortisol synthesis and secretion
aamp04928  Parathyroid hormone synthesis, secretion and action
aamp04929  GnRH secretion
aamp04933  AGE-RAGE signaling pathway in diabetic complications
aamp04934  Cushing syndrome
aamp04935  Growth hormone synthesis, secretion and action
aamp04961  Endocrine and other factor-regulated calcium reabsorption
aamp04970  Salivary secretion
aamp04971  Gastric acid secretion
aamp04972  Pancreatic secretion
aamp04973  Carbohydrate digestion and absorption
aamp05010  Alzheimer disease
aamp05016  Huntington disease
aamp05017  Spinocerebellar ataxia
aamp05022  Pathways of neurodegeneration - multiple diseases
aamp05142  Chagas disease
aamp05143  African trypanosomiasis
aamp05146  Amoebiasis
aamp05163  Human cytomegalovirus infection
aamp05200  Pathways in cancer
aamp05415  Diabetic cardiomyopathy
aamp05417  Lipid and atherosclerosis
Module
aamp_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:aamp00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    119824882 (Plcb3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    119824882 (Plcb3)
   04310 Wnt signaling pathway
    119824882 (Plcb3)
   04371 Apelin signaling pathway
    119824882 (Plcb3)
   04020 Calcium signaling pathway
    119824882 (Plcb3)
   04070 Phosphatidylinositol signaling system
    119824882 (Plcb3)
   04072 Phospholipase D signaling pathway
    119824882 (Plcb3)
   04071 Sphingolipid signaling pathway
    119824882 (Plcb3)
   04022 cGMP-PKG signaling pathway
    119824882 (Plcb3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    119824882 (Plcb3)
   04081 Hormone signaling
    119824882 (Plcb3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    119824882 (Plcb3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    119824882 (Plcb3)
   04613 Neutrophil extracellular trap formation
    119824882 (Plcb3)
   04621 NOD-like receptor signaling pathway
    119824882 (Plcb3)
   04062 Chemokine signaling pathway
    119824882 (Plcb3)
  09152 Endocrine system
   04911 Insulin secretion
    119824882 (Plcb3)
   04922 Glucagon signaling pathway
    119824882 (Plcb3)
   04929 GnRH secretion
    119824882 (Plcb3)
   04912 GnRH signaling pathway
    119824882 (Plcb3)
   04915 Estrogen signaling pathway
    119824882 (Plcb3)
   04921 Oxytocin signaling pathway
    119824882 (Plcb3)
   04926 Relaxin signaling pathway
    119824882 (Plcb3)
   04935 Growth hormone synthesis, secretion and action
    119824882 (Plcb3)
   04918 Thyroid hormone synthesis
    119824882 (Plcb3)
   04919 Thyroid hormone signaling pathway
    119824882 (Plcb3)
   04928 Parathyroid hormone synthesis, secretion and action
    119824882 (Plcb3)
   04916 Melanogenesis
    119824882 (Plcb3)
   04924 Renin secretion
    119824882 (Plcb3)
   04925 Aldosterone synthesis and secretion
    119824882 (Plcb3)
   04927 Cortisol synthesis and secretion
    119824882 (Plcb3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    119824882 (Plcb3)
   04270 Vascular smooth muscle contraction
    119824882 (Plcb3)
  09154 Digestive system
   04970 Salivary secretion
    119824882 (Plcb3)
   04971 Gastric acid secretion
    119824882 (Plcb3)
   04972 Pancreatic secretion
    119824882 (Plcb3)
   04973 Carbohydrate digestion and absorption
    119824882 (Plcb3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    119824882 (Plcb3)
  09156 Nervous system
   04724 Glutamatergic synapse
    119824882 (Plcb3)
   04725 Cholinergic synapse
    119824882 (Plcb3)
   04728 Dopaminergic synapse
    119824882 (Plcb3)
   04726 Serotonergic synapse
    119824882 (Plcb3)
   04720 Long-term potentiation
    119824882 (Plcb3)
   04730 Long-term depression
    119824882 (Plcb3)
   04723 Retrograde endocannabinoid signaling
    119824882 (Plcb3)
  09157 Sensory system
   04742 Taste transduction
    119824882 (Plcb3)
   04750 Inflammatory mediator regulation of TRP channels
    119824882 (Plcb3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    119824882 (Plcb3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119824882 (Plcb3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    119824882 (Plcb3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    119824882 (Plcb3)
   05142 Chagas disease
    119824882 (Plcb3)
   05143 African trypanosomiasis
    119824882 (Plcb3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    119824882 (Plcb3)
   05016 Huntington disease
    119824882 (Plcb3)
   05017 Spinocerebellar ataxia
    119824882 (Plcb3)
   05022 Pathways of neurodegeneration - multiple diseases
    119824882 (Plcb3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    119824882 (Plcb3)
   05415 Diabetic cardiomyopathy
    119824882 (Plcb3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    119824882 (Plcb3)
   04934 Cushing syndrome
    119824882 (Plcb3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:aamp04131]
    119824882 (Plcb3)
Enzymes [BR:aamp01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     119824882 (Plcb3)
Membrane trafficking [BR:aamp04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    119824882 (Plcb3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    119824882 (Plcb3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PI-PLC-Y PH_14 PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 119824882
NCBI-ProteinID: XP_038201371
LinkDB
Position
1:complement(150770141..150785263)
AA seq 1225 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDPNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVAGPDPVNTTFLNF
MAVQDDTVKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSMDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLSAGVPLPSPQDLMGRILVKNKKRHRPSTGVPDS
SVRKRPLEQSNSALSESSATTEPSSPQLGSPSSDSCPGLSNGEEVGLEKTSLEPQKSLGE
EGLSRGPNVLIPADREDEEEDEEEEETTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDMPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGRFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASTDTYQETQSQQP
GSQFLPNPTPNPLDASPRWPPGPTTSPTSTSLSSPGQRDDLIASILSEVTPTPLEELRNH
KAMVKLQSRQDRDLRELHKKHQRKTVALTRRLLDALAQARSEGRCRPSPGAPVSNPEDIK
EYREFQNRQVQILLELREAQADAETERRLEHLRQAQQRLREVVLDAHTTQFKRLKELNER
EKKELQKILDRKRNNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLEEAQKQRHER
LLAGQQQVLQLLVEEEPKLLAQLTQECREQRERLPQETRRCLLGETSEGLGDGPQVACAS
NGHAPASGGHLSGADSESQEENTQL
NT seq 3678 nt   +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcttccagtcggaacctg
gtgaccctgcgtgtggatcccaatggtttcttcttgtactggacgggacccaatatggag
gtggacacgctggacatcagctccattagggacacacggacaggtcgttatgcccgccta
cccaaggatcccaagattcgagaagtactgggctttgggggccctgacgcccggctcgaa
gagaagctgatgacagtggtggctgggccagacccagtaaacaccacgttcttgaacttc
atggccgtgcaggatgacacagtcaaggtctggtcggaggagttgttcaaactggctatg
aacatattggctcagaatgcctcccggaacaccttcctgcggaaagcatacacaaagctg
aagctgcaggtgaaccaggatggacggattccagtcaagaacattctgaagatgttctca
gcagacaagaagcgggtggagactgcgctggagtcctgtggcctcaacttcaaccggagt
gagtccatccggcctgatgagttttccttggaaatctttgagcggttcttgaacaagctg
tgtctgcgaccggatattgacaagatcctgctcgagataggtgccaagggcaagccgtac
ctcactctggagcagctcatggactttatcaaccagaagcaaagagaccccagactcaat
gaagtgctgtacccgccactgcggccctcacaggctcggttgctcattgagaagtatgag
cctaaccagcagttcctggagcgagaccagatgtctatggagggtttcagccgctaccta
ggaggggaggagaatggcatcctgccgctggaggccctggatctgagcatggacatgaca
cagcccctgagcgcgtacttcatcaattcctcacacaatacctatctcactgcgggccag
ctggctggaacatcgtcagtggagatgtaccgccaggcgttgctgtggggctgccgctgt
gtggagctggatgtatggaagggacggccaccggaggaagagcccttcattacccatggt
tttaccatgaccactgaggtgccattgcgtgatgtgcttgaggccattgctgagacagcc
ttcaagacctcaccctaccctgtcatcctctccttcgagaaccatgtggactcggcaaaa
cagcaggccaagatggctgagtactgccgctctatctttggggatgcgctgctcattgac
cctctggataaatacccgctctctgcgggcgtccctctgcctagtccacaagacctgatg
ggacggatcctggtgaagaataagaagcgacatcggcccagcacaggcgtccccgacagc
tcagttcgcaagaggccgctggagcagagcaactcagccctgagcgagagctcagccacc
acagagccttcctcaccccagcttgggtcccctagctcagatagctgccctggcctaagc
aatggggaggaggtgggacttgagaagaccagcctggaaccccagaagtctctaggcgag
gagggcctcagccggggacctaatgttctcatacctgctgaccgagaggatgaagaagag
gatgaagaagaagaggaaacaacggatccgaagaaacccaccacggatgagggcacagcc
agcagtgaagtcaatgccactgaggagatgtctacactcgtcaactacattgagcccgtg
aagttcaagtcttttgaggctgctcgaaaaaggaacaagtgcttcgagatgtcatccttt
gtggagaccaaggccatggagcagctgaccaagagtcccatggagttcgtggaatacaac
aaacagcagcttagccgcatctaccccaagggcacccgtgtggactcctccaactacatg
ccccagctcttctggaatgtgggttgccagcttgtggctctcaacttccagaccttggac
atgccaatgcagctcaacgcaggcgtcttcgaatacaatgggcgcagtgggtacttactc
aagcctgagttcatgcggcggccagataagtcctttgaccccttcactgaggtcattgta
gatggcatagtggccaacgccttgcgggtcaaggtgatttcggggcagttcctgtctgac
aggaaggtgggcatctacgtcgaagtggacatgtttggtctcccagttgacacaaggcgc
aaatatcgcacaaggacatcccaggggaactcattcaaccctgtgtgggatgaagagccc
tttgacttccccaaggttgtgctgcccacgctggcctcacttcgcattgcagcttttgag
gagggtggcagatttgttggacaccgcatcctgcctgtctctgccatccgctcaggatac
cactatgtctgtctgcgaaatgaggctaaccagccactgtgtctgcctgccctgcttatc
tacactgaagcttctgactacatcccagatgaccaccaggactatgcagaggccctgatt
aaccccatcaagcatgtcagcctaatggaccagcgggccaagcagctggctgctctcatt
ggggagagtgaggctcaggccagtacagacacatatcaggagacgcagtctcaacagcca
gggtcacagttcttgcccaaccccacacctaacccactggatgcctcacctcgctggcct
ccaggtcctactacctcccccactagcacctccctcagtagcccagggcagcgagatgat
ttgattgccagcattctctctgaggtgacccctacccccctagaggagctccgaaaccac
aaggctatggtgaagctccagagccgacaggaccgagacctgagggagctgcataaaaag
caccagcgcaagactgtggccctcacccgtcgccttctggatgccttggcacaggccaga
tctgagggcagatgccggccctcccccggtgccccagtcagcaatcctgaagacattaag
gagtatcgagagttccagaacagacaggtacagatcctgctggagctgagggaggcccag
gcagatgcagaaaccgaacgaaggctggagcacctcagacaggctcagcagcggctcagg
gaggttgtcctggatgcacacacaacccagttcaagagactgaaggagctgaatgaaagg
gagaagaaggagcttcagaagatcctggacagaaagcgcaacaacagtatctcagaggcc
aagacaagggagaagcataagaaggaggtggaactgacagagattaatcggcggcatatc
actgagtcagtcaactctatcagacggctggaagaggcccagaagcagcgccatgagcgc
ctcctggcggggcagcagcaagtcctccagctgctagtggaagaggagcccaagctgctg
gcccagctgacccaggagtgtcgggagcagcgggagaggttgccccaggagacccgtcga
tgcctgctaggcgagacatcagaggggctaggggacggcccccaggtggcttgtgccagc
aatggtcatgcacctgcgagtggcgggcacctgtccggcgctgactcggagagccaggag
gagaacacccagctctaa

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