Anguilla anguilla (European eel): 118220641 Help Entry 118220641         CDS       T07545                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism aang  Anguilla anguilla (European eel) Pathway aang04020   Calcium signaling pathway aang04260   Cardiac muscle contraction aang04261   Adrenergic signaling in cardiomyocytes aang04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:aang00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     118220641 (ryr2a)    04020 Calcium signaling pathway     118220641 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     118220641 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     118220641 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:aang04040]     118220641 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:aang04990]     118220641 (ryr2a) Ion channels [BR:aang04040]  Voltage-gated cation channels   Ryanodine receptor    118220641 (ryr2a) Domain-containing proteins not elsewhere classified [BR:aang04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    118220641 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  118220641 NCBI-ProteinID:  XP_035260543 LinkDB All DBs Position 2:complement(13178983..13341585) Genome browser AA seq 4976 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCSATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGQVDVEKWKFMMKTAQGGGHRTLLYGHAVL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRAVHYEGGAVSIHARSLWRLETLRVAWSGSHTRWGQPFRLRHV TTGKYLSLMDDKGLLLTDKEKADVKSTAFCFRSSKEKLDFGVRKEVDGMGVPDIKYGDSV CYIQHVDTCLWLTYQAVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKGKTSTLDLPIESVSLSLQDLIGYFQPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFSDVAGKEAGEAWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGISEGSAQYKKWYYELIVDQVETFVTAEATHLRVGWATTDGYSPYPGGGEGWGGNGVGD DLYSYSFDGLHLWSGCIARTVSSPNQHLLRADDVVSCCLDLSAPSISFRINGQPVQGMFE NFNADGLFFPVTSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPREKLRVEHSQEY KQDHGGTRDLLGPTVTLTQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWTYGTVRDDNKRQHPCLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGVADEHAEEK VKNLKLSPKYELSSGYKPAPMDLSHIKLASTQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYALLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARSDMSNL LAERFRVFRAEKPYSVNAGKWYFEFEVVTAGEMRVGWARPGCLPDQELGSDEQAFVFDGF KAQRWHQGNEHFGRSWQLGDVVGCMVDMNEHTMMFTLNGEVLLDDSGSELAFKDFEVWEG FIPVCSLGVSQMGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDLTMWLSKRLPQYIP VPPNHEHIEVMRIDGTVESSPCLKVMQRSFGSQNSNTDIAFYRLSMPIECAECFSKSPGG TLPSNGSFFSPKKELEDFETVSDFEVLMKTAHGHLGSNGPEKDKDEFNNHKDYNQEKPSK LKQRFMLKRSKPDFSTSHSSARLSEEVLADERDDYEYLMQTSTYYYSVRIFPGQEPSSVW VGWVTSDFHQYDTAFDLEKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGESTSPGQSRNN NGLEIGCLVDTANGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKN VMPLSAGLFKSEQKNPMPQCPPRLHVQFLTPVLWSRVPNHFPKVETSRINDRHGWLVHCC EPLQFMSLHIPEENRSVDILELTEQTDLLKFHFHTLRLYSAVCALGNNRVAHALCSHVDE AQLLYAIENKYMPGLLRTGYYDLLIDIHLSTYATARLMMNNEYIVPMTDETKSITLFPDE KKKHGLPGIGLSTSLRPRMHFSSPSFVSVGGDFFQYSPEFPLDILKTKTIEMLTEAVREG SLHVRDPIGGSTEFLFVPLIKLFYTLLIMGVFHNGDLKNILQLIEPSVFSEDSGRERADT PDGNGFKGELRIEGAGAEDGGRAGNVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRI EAVVAFSDDFVANLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDE KQDCPCPEDIREQLLDFHEDLMTHCGIEIDDDKANEADGDFTIRGRLLSLVEKVAYLKKK MADLPKKKKSKKPSTLQHLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRAL PKTYTINSVSVEDTINLLASLGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLM RALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLL ENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCLMLVS KGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNG LLAAMEEAIKISEDPSRDGPSPTSESSRTLSDMLEDEEDDTIHMGNAIMTFYAALIDLLG RCAPEMHLIHAGKGEAIRIRAILRSLIPIEDLEGVISIPFPMPTLAKDGTVVEPDMSAGF CPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTKCAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKL RPSMMQHLLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLSGGWGSFGAASDEELHL SRKLFWGIFDALSQKRYDQELFKLALPCLSAVAGALPPDYMESNYVAMMEKQSSMDAEGN FNPQPVDTSNVTVPEKLDYFINKYAEHSHEKWSTDKVMCPVSYTAEFANGWVHGDQLCEA SKVHPLLKPYKGLSEKDKEVYRWPIKESLKTMLAWGWSIERTKEGDPAGLHNRARRISQS SQLSIEGTHGFSPRPIDMSNVTLSRDLHSMAELLAENYHNIWAKKKKIELEAKGGGSHPL LVPYDTLTAKEKSRDREKAQDILKFFQINGYTVSRAMKEQELDTPSIEKRFAYTFLQQLI TYVDEAHKHMMEFDIGTWGKGEKIPHEQQMKFFGKVVLPLVDQYFKNHRLYFLSTAIRPL SSGGHASNKEKEMITSLFCKLGVLVRHRISLFGNDSTSIVNCLHILGQTLDARTVMKTGL DTVKAALRAFFDNAAEDLEKTMENLKQGQFTHTRTQPKGVTQIINYTTVALLPVLSSLFE HIGQNLFGEDLILDDVQVSCYRILNSLYSLGTSKSIYVERQRPALGECLAAFSGAFPVSF LEPHLNKYNTYSIYNTKGSRERAALGLPAQVEEMSPLIPSLEKSLEEIMELAESGMRYTQ MPHVMEVVLPMLCSYMSHWWEHGPENNPERADKCCTSLTSEHMNTLLGNILKIIYNNLGI DEGAWMKRLAVFSQPIISKAKAQLLKTHFLPLMEKLKKKAATVLLDEEHMKAEGRGEMSE AELLILDEFTILVRDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIFWAKSH NFKREEQNFVVQNEINNMSFLITDTKSKMSKGAMSDQERKKMKRKGDRYSMQTSLIVAAL KRLLPVGLNICAPGDQELIALAKNRFTQKDTEDEVREIIRNNLHLQGKLEDPAIRWQMAL YKDLPNRSEDTSDPEKTVERVLDIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVAC FRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGGEEPSEEDEGAKRI DPLHQLIQLFSRTALTEKCKLEEDNLYMAYADIMAKSCHDEEDEDGEEVKSFEEKEMEKQ KLLYQQARLHDRGAAEMVLQTISASKGEMGPMVASTLKLGIAVLNGGNSTVQQKMLDYLK DKKDVGFFQSLAGLMLSCSVLDLNAFERQNKAEGLGMVTEEGSVITHERGEKVMQDDEFT CDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKD VIDEQGQRNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQM KLSQDSSQIDLLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKF FDMFLKLKDLTSSDAFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENE LLDYEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELAESVLNYFQPYLGRI EIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDT IFEMQLAAQMSDIGERSASKEESEKEKPEEDNPEMGFFSVTTVRTALLALRYNVMMLMKV LSMKSLKKQMKKMKKMTVKDMVTTLVAFYWSLLMGLLHFAFSVSRGFFRIVYSTFLGGSL VEGAKTMKVADLLANMPDPTQDEVRGEGEEAEKRHPDKSSAEEDLADLAVNIEDTDLLSD IFGLDLRREGGQYKLMPHNPNASLTDLLNSPVPPPPTPSPELRRRNQGKGSTDEDGEGKE ESQSEPEKAEGENGEKDVKPKDDKPKQKVRQHHTSKSEEPELQESAFWKKIIAYQRKLLN YFARNFYNMRMLALFVAFAINFILLFYKVSTSSAVVEEKEVVYSGPSDTSVRWSPVEGVP HRTVTVHFVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLE FDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLG MDKAALDFSDAHEKKKPKKDSSLVAVLNSVDVKYQIWKLGVVFTDNSFLYLAWYMTMSIL GHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRK FYNKSEDGESPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFF FFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQ EHNLANYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14931 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggagaaggcgaggatgaaatccagttcttacgaactgatgatgaggtg gtgctccagtgttccgccaccgttcacaaggagcagcagaagctatgtctggccgccgag ggctttggaaacagactctgcttcttggagtctacctcaaactccaagaatgttccgccg gacctgtcgatctgcaccttcgtgctggagcagtccctgtcggtccgggccctgcaggag atgctggccaacaccgaggagaaagccgaagggcaagttgatgtggaaaaatggaaattt atgatgaagacggcccagggagggggacaccgtaccctgctctacggacacgcggtgctg ctacgacactcctacagtgggatgtacctttgctgtttgtccacttcgcgatcttcaacc gataaactggcatttgatgttgggcttcaagaagatacaacaggtgaagcctgctggtgg accatccaccccgcctccaagcagaggtcagagggcgagaaggtgcgtgtcggggatgac ctcatcctggtcagcgtctcctccgaacggtacctgcatctatcatatgggaacgggagc ctgcacgtggacgctgccttccagcagaccctctggagcgtggcgcccatctgctccggg agcgaagtggcacaagggtacctgataggtggggatgtcctgcggctgctccacggacac atggacgagtgtctgactgtcccgtccggagagcacggggaggagcaacgcagggcggtg cactatgagggaggagccgtatccatccacgcccgctccttatggaggctggagacactg cgagttgcgtggagcgggagccacacccgctggggccagcccttccgcctcaggcacgtc accaccggcaagtacctcagcctcatggacgacaagggcctgctgctgacggacaaggag aaggccgacgtcaaatccacggccttctgcttccgctcctccaaggaaaagctggacttt ggggtgaggaaagaggtcgacggcatgggagtccccgacattaagtacggcgactccgtg tgctacatccagcacgtggacacctgcctgtggctcacgtaccaggccgtggacgccaag tgcgcgcggatgggcggcgtgcagcgtaaggccatcatgcaccacgaggggcacatggac gacgggctgacgctgtcgcgctcgcagcacgaggagtcccgcaccgccagggtcatccgc agcaccgtcttcctcttcaaccgcttcatcagaggtctggatgccctgagtaaaaaagga aagacctcaacgctagatctgccaatcgagtctgtcagcctgagtctgcaggatctgatt ggctacttccagccgcccgacgagcatctggaacatgaggacaagcaaaacaggctgcgg gcattgaagaacagacagaatctcttccaggaagaggggatgattaacttggtcctggag tgtatcgaccgcttacatgtgtacagcagcgctgctcatttctctgatgttgccgggaag gaagccggggaggcctggaagtctatactaaactcattatacgagctactggcggctttg ataagggggaacagaaagaactgcgctcagttttccggctcattggattggctgatcagc aggctggagagactggaagcctcttctgggattctggaggttttgcactgcgttcttgtg gaaagccccgaggcccttaacatcatcaaagagggtcacattaaatctatcatctccctc ctggacaaacatgggcggaatcacaaggtcttggacgtcctctgctccttgtgcgtgtgc cacggtgtggcggtgcgctcaaaccagcatctcatctgtgacaacttactgcctgggcgg gacctgctccttcagacgcgcctggtcaaccacgtcagcagcatgcggccaaacatcttc ctgggcatcagcgaaggctccgcccagtacaaaaagtggtactacgagctgatcgtggac caggtggagaccttcgtcacggccgaggcgacccacctgcgcgtgggctgggccaccacc gacgggtactccccctaccccggcggcggagagggctgggggggcaacggcgtcggcgac gacctctactcctacagctttgacgggcttcacctctggtcaggctgcatcgcgcgcacg gtgagctcgcccaaccagcacctcctccgagccgacgacgtggtcagctgctgcctggac ctcagcgcccccagcatctccttccgcatcaacggccagcccgtccagggcatgttcgag aacttcaacgccgacggcctcttcttccccgtcaccagcttctcggcgggggtgaaagtg cgtttcctgttgggagggcggcacggagagttcaagtttctcccgcccccgggatacgcc ccttgtttcgaggcggtgttaccccgtgagaagctgcgggtggaacacagccaggagtac aagcaggaccacggtgggacgcgtgaccttctgggcccaaccgtgaccctcacgcaagct gccttcaccccgactcctgtggacaccagccagatcgttctgccccctcatttggagcgg atccgggagaagttggctgaaaacatccacgagctctgggtcatgaataagattgaactt ggctggacgtatgggactgtacgagatgacaacaagagacaacacccctgcctggttgag ttctccaagcttccggaacaagagcgcagttacaacctccagatgtctctggaaaccttg aagactctcctggccctgggctgtcacgtgggtgtggccgatgagcatgccgaagagaag gtgaagaatctgaagctgtcccccaagtatgagctgtcgagtggatacaagcccgccccc atggacctgagccacatcaagctggcgtccacgcaggaggccatggtggacaagctggcg gagaatgcccacaacgtgtgggccagggacaggatccgacagggctggacgtacggcatc cagcaggatgtgaagaacaggaggaaccctcgcctcgttccctacgccctgctggacgag aggaccaaaaagtccaacaaggacagcctgagggaggctgtgcgcaccctgctggggtac gggtacaatctggaggcccccgaccaagatcacgccgcgcggtccgacatgagcaacctg ctggccgagaggttccgggtcttccgcgcggagaagccgtatagcgtgaacgctggaaag tggtactttgagttcgaggtggtgacggcgggggagatgagggtgggatgggctcggcct ggctgtctgcctgaccaggagctgggatccgacgagcaggcttttgtgttcgatggcttc aaggcgcagcgctggcaccagggaaacgagcacttcggccggtcctggcagctgggcgat gtggtgggctgcatggtggacatgaacgagcacaccatgatgttcaccctcaacggggag gtgctcctcgacgactcgggctctgagctggccttcaaggactttgaggtttgggaagga ttcatcccggtgtgcagcctgggcgtgagtcagatgggcaggatgaatttcggaaaggac gtcagcactctcaagtacttcaccatctgcggcctgcaggaaggctacgagcccttcgcg gtcaacatgaaccgcgacctgaccatgtggctgagcaagaggctgccccagtacatccct gtcccaccaaaccacgagcacattgaggttatgaggatcgatggaaccgttgagagctcg ccgtgtctgaaggtcatgcagaggtcattcgggtctcagaacagtaacaccgacatcgcg ttctaccgcttgagcatgcccattgagtgcgcggagtgtttctccaaatcgccggggggc actctgccatccaacggcagcttcttctcaccaaagaaggaactggaggattttgagacg gtctcagactttgaggtcctcatgaaaacggctcatggacacttgggttccaacggccca gagaaagacaaggatgagtttaacaaccacaaggactacaaccaagagaagccttccaaa ctcaaacaaaggttcatgctgaagcggagtaagcctgacttcagcaccagccactcgtca gctcgcctgtcagaggaagtgctggctgacgagagggacgactatgagtacctgatgcag acgtccacgtactattattctgtgaggatcttccctggccaggagccctccagtgtgtgg gtgggctgggtaacctcagatttccaccaatatgacacggccttcgacctggagaaggtg cgcactgtgaccgtcaccctgggcgacgagaagggcaaggtgcacgagagcatcaagcga agtaactgctacatggtgtgggccggagagagcaccagcccaggacagagccgcaacaac aacgggctggagattggctgtctggtggacaccgccaatgggctgctgaccttcaccgcc aatggcaaggagctcagcacctactaccaggttgagcccagcaccaagctgttccctgcg gttttcgctcaggccaccagccccaacgtgtttcagttcgaactgggacggataaagaac gtgatgcccctgtcagcgggcctgttcaagagcgagcaaaagaaccccatgccccagtgc ccgccccggctgcacgtccagttcctcacgcccgtcctgtggagccgggtgcccaaccac ttccccaaggtggagacgtcccgcattaacgaccgccacggctggctggtgcactgctgc gagcctctgcagttcatgtccctgcacatccccgaggagaacaggtcagtggatatcctg gagctgacagaacagacagacctgctgaagtttcacttccacaccctgaggctgtactcg gccgtctgcgccctgggcaacaaccgggtggcgcacgccctctgcagccacgtggacgag gcccagctgctctacgccatcgagaacaagtacatgccgggcctgctgaggacgggctac tacgacctgctcatcgacatccacctcagcacctacgccaccgcccgcctcatgatgaac aacgagtacatcgtgcccatgactgacgagaccaagagcatcacgctcttccccgacgag aagaagaagcacgggctcccgggcatcggcctcagcacctccctccggcccaggatgcac ttctcctcgcccagctttgtcagcgtgggcggcgacttcttccagtacagccccgagttc ccgctggacatcctgaagaccaagaccatcgagatgctgacggaggccgtgcgggagggc agcctgcacgtgcgggaccccatagggggcagcaccgagttcctgttcgtgcccctcata aagctgttctacaccctgctcatcatgggtgtcttccacaatggcgacctcaagaacatc ctgcagctcatcgagcccagcgtcttctccgaggactcaggccgcgagcgggccgacacg cccgacggcaacggcttcaagggcgagctccggatagagggagcgggggcagaggatgga gggagggcggggaacgtccccaaagagggactgctccagatgaagctcccagagccggtc aagctgcaaatgtgtcatctgcttcagtacctgtgcgactgtcaggtaaggcacaggata gaggcggtggtggccttctccgacgactttgtggccaacctccaggacaaccagcgcttc cgctacaacgaggtgatgcaggcgctcaacatgtctgccgcgctgaccgctaggaagacc aaagagtttcgatcgccaccacaggagcagatcaacatgctgctgaactttaaggatgag aagcaggactgcccgtgtccagaggatatcagagaacagcttctggacttccatgaggac ttgatgacccactgtggaattgagattgatgatgacaaggccaatgaagcagatggggat ttcaccatcagaggtcgtcttctgtccctcgtcgagaaagtggcctacttaaagaagaaa atggctgacttgccaaagaaaaaaaagtcgaagaagccctccactctgcagcacctgatc tccgagaccatggtgcgctgggcccaggagtccgtgatcgaggacccggagctggtccgg gccatgttcgtcctgctgcaccggcagtacgacggcatcgggggccaggtccgtgccctg cccaagacctacaccatcaactccgtgtccgtggaggacaccataaacctgctggcctcc ctgggccagatccgctccctgctgagcgtgcgcatgggccgggaggaggagaagctgatg atccgaggcctgggagacattatgaacaataaagttttctaccagcacccaaacttgatg cgggctctgggcatgcatgagactgtcatggaggtgatggtgaatgttctgggcggagga gaatcaaaggaaatcacatttcctaagatggtggccaactgctgtcgttttctttgctac ttctgtcgcatcagtagacaaaaccaaaaagccatgttcgatcacctcagttacctgctg gaaaacagcagtgtcggcctcgcgtccccctccatgaggggttccactcccctggacgtg gccgccgcgtctgtgatggataacaatgagctggctctggccctccgagagccagacctg gagaaagtggtgcagtacctagcaggctgtggtctgcagagctgccttatgcttgtatct aagggctaccctgatattggctggaaccctgtagaaggggagcgctatttagatttcctc cgcttcgctgtattctgcaatggagagagcgtggaggaaaacgccaatgtggtggtgagg ctgctgattcgccggccagagtgctttggccccgccctgcggggggaaggaggaaatggc ttactggccgccatggaggaggccatcaagatctcggaggacccaagcagggatggcccc tcccccacctctgagtccagcaggaccctcagtgacatgctggaggatgaagaggatgac actatccacatgggaaacgcgatcatgaccttctacgccgctctcattgacctgctgggg cgctgtgccccggagatgcatctgatccacgctggaaagggggaggccatccgcatccga gccatcctgcgctccctgatcccaatcgaggacctggagggggtgatcagcattcccttc ccaatgccaaccctagccaaagacggaacagtggtggagccagatatgtcggcaggcttc tgtccggatcacaaggccgccatggtgctgttcctggaccgagtgtacggcatcgaggac cagaacttcctgctgcacctcctggaggtgggcttcctgccggacctccgggcagctgct tcgctggacacggccgcgctgagcgccacagatatggccctggctctaaaccgctacctg tgcaccgccgtgctgcccctgctgaccaaatgcgcccccctgttcgccgggacggagccc ttcgcctcgctcatcgactcgctgctccacaccgtgtaccgcctgtccaagggctgctgc ctgaccaaggcccagcgagacgccatcgaggagtgcctgctggccgtgtgcggtaaactg aggccctccatgatgcagcacctgctcaggaggctggtgtttgatgttcctcttctcaac gagcacacaaaaatgccactcaagttgctgaccaatcactacgagcggtgctggaagtac tactgcctgtctggaggctgggggagttttggggccgcgtcggacgaggagctgcacttg tccagaaaactcttctggggaatatttgacgccctgtctcagaagaggtacgaccaggag ctctttaagctggcactgccctgcctgagtgcggtggcaggggcgctgcctccggactac atggagtccaactatgtggccatgatggagaagcagtcctccatggacgccgagggcaac ttcaacccccagcctgttgacacctcaaatgtcacagtccctgagaagctggactatttc atcaataaatatgcggaacattctcacgaaaagtggtccacggacaaggtgatgtgtcct gtctcttatacagctgagtttgccaacggctgggttcatggggatcagctgtgcgaggcc tccaaagtgcatcctctcctcaagccgtacaaaggcctgtccgagaaggacaaggaagtg taccgatggccaattaaggagtctcttaagaccatgctggcctgggggtggagtatcgag aggacgaaagagggagaccctgcgggactgcacaaccgcgcccgccgaatttctcagtcc agtcagctgtccatcgaaggcacacatggcttcagcccacggccgatcgatatgagcaac gtgaccctttccagagacctgcactctatggcagagctgcttgcagagaactatcataat atttgggcaaagaagaaaaagatagagctggaagccaaaggaggagggagccatccttta ttggtgccctacgacactcttactgccaaagagaaatccagagacagagaaaaagcacaa gacatcctcaagttttttcagatcaatggctacacggtctcaagggctatgaaggagcag gagctagacaccccctccatagagaaacgtttcgcctacaccttcctccagcagctcatt acttacgtggatgaggcacacaaacacatgatggagtttgacatagggacatggggcaaa ggagagaagattcctcatgagcagcaaatgaagttttttgggaaggtggtcctgcccttg gttgatcagtatttcaagaatcaccgcctctacttcctgtctactgcaatacggcccctc agcagtggaggccacgcctccaacaaagagaaggagatgatcaccagccttttctgcaaa cttggagtacttgtcagacataggatatcactgtttggaaatgattctacctcaatcgtg aactgtcttcatatcctgggccagactctggatgccaggacggtgatgaagaccggcctg gacacggtgaaggcggcgctgcgggccttcttcgacaacgcggcggaggacctggagaag accatggagaacctgaagcagggccagttcacgcacaccaggacccagcccaagggcgtg acccagatcatcaactacaccacggtggccctgctccccgtgctctcctccctcttcgag cacatcgggcagaacctctttggcgaagacctcatattggatgatgtccaggtgtcctgt tacaggattctcaacagcctctattcgcttggcaccagcaaaagcatctatgttgaaagg cagcgtccggctctgggtgaatgtctggccgcattttctggagctttccctgtgtccttt ttggagccacacctgaacaagtacaacacctactccatctacaacaccaaagggtcccgt gaaagagcagcgctgggtctgccagcccaggtggaggagatgtcccccctcatcccgtcc ctggagaagtcgctggaggagatcatggagctggccgagtcaggcatgcgctacacccag atgccccatgtgatggaggtggtgctgcccatgctctgcagctacatgtcgcactggtgg gagcacggcccggagaacaacccggaacgggcggacaaatgctgcacctcgctcacctcc gagcacatgaacacgctgctgggcaacatcctgaagatcatctacaacaacctgggcatc gacgagggggcgtggatgaagcgcctggcagtgttctctcagccaatcatcagcaaggcc aaggcccagctgctgaagacgcacttcctgcctctgatggagaagctgaagaagaaggcg gcgaccgtcctgctggacgaggagcacatgaaggccgaggggcggggcgagatgtccgag gcggagctgctgatcctggatgagttcaccatcctggttcgggacttgtacgccttctac ccactccttatccgattcgtcgactacaacagagcaaaatggctcaaggaaccaaaccca gaggcagaggaactgttccgcatggtggcagaagtttttatattctgggccaaatctcat aatttcaaaagggaggagcagaactttgtggtccagaacgaaatcaacaacatgtccttc ttgatcaccgataccaagtccaaaatgtcaaagggagccatgtcggaccaagagaggaaa aagatgaagaggaagggggaccgctactccatgcagacctccctcatcgtggccgccctg aagaggctgcttcccgtgggcctgaacatctgcgcccccggggaccaggaactcatcgcg ctggccaagaaccgcttcacccagaaagacacagaagacgaggttcgggagatcatccgc aataaccttcacctgcagggaaagctggaggaccccgcgattcgatggcagatggctctg tacaaagacctgcccaacaggagcgaggacacctcggacccagaaaagacagtggagaga gttctagacatcgcccacgttctgttccatctggaccaggttgagcacccccagagaagt aagaaggctgtgtggcacaagcttctctccaagcagcggaagcgggctgttgtggcctgt ttcaggatggctcccctgtataacttacccaggcaccgagccgtcaacctgttcctgcag ggatatgagaagtcttggatcgaaacggaggagcattacttcgaagataagctaatagag gatttggctaaaccgggaggcgaggagccgtcggaggaggacgagggagccaagcggatc gatcctctccaccagctaatccagctcttcagccgaaccgccctgacggagaagtgtaag ctagaggaagacaacctgtacatggcctatgctgacatcatggcaaagagctgccatgat gaagaggatgaggatggagaagaggtgaaaagctttgaagaaaaagagatggagaaacag aagctgctgtaccagcaggccaggcttcacgatcggggcgcagcagaaatggtgctgcag accatcagtgccagcaaaggggaaatgggaccaatggtggcatccacgctgaagctgggt atcgctgtactgaatggtggaaactccacagtgcagcagaaaatgctggactatctgaaa gacaagaaggacgtgggtttctttcagagtctggcggggctcatgctgtcctgcagcgtg cttgacctcaacgcgttcgagaggcagaacaaagccgaagggctgggcatggttacggag gagggctcagtcatcactcatgagcgtggagagaaggtgatgcaggacgatgagtttacc tgtgacctctttcgcttccttcaactgctgtgtgaaggacacaactcagattttcagaat tacctgagaacacagacaggaaacaacacgactgtcaacatcatcatctcaactgttgac tatcttctccgagttcaggaatcaatcagtgatttctactggtattactctggaaaagat gtcatcgatgagcaagggcagcgcaatttctccaaggcaatcaatgtggccaagcaggtc ttcaacaccctcacagagtacatacagggtccatgcactgggaaccagcagagtctggct catagccgactgtgggatgcagtggtggggttcctccacgtctttgcacacatgcagatg aagctttcacaggattctagtcagattgacttattgaaagagcttatggatcttcagaag gatatggttgtaatgctgctgtccatgttggaaggaaatgttgtaaatggaactattggt aaacagatggttgacatgctggtagaatcctcaaacaacgtggaaatgattctgaagttc tttgacatgttcctcaaactgaaagacttgacatcatcagatgccttcaaggagtatgat cctgatgggaagggggtgatctcaaagcgagacttccacaaggccatggagagccacaaa cattacactcaatccgagactgagttcctgctctcctgtgctgagacggatgaaaacgag ctcttggactatgaggaatttgtggagcggttccacgagccagccaaagacattggcttc aatgtggccgtcttgttgacgaacctgtctgagcacatgcctcacgacacacggctccag accttcctggagttggcggagagcgtgctcaactactttcaaccttacttgggtcgcatc gagatcatgggcagtgccaaacgcatcgagcgggtctactttgagatcagtgagtccagc cgcactcagtgggagaagccgcaggtcaaggagtccaagcggcagttcatctttgacgtg gtcaacgagggcggcgagaaggagaagatggagctcttcgtcaacttctgcgaggatacc atcttcgagatgcagctggcggcccagatgtccgacatcggggagcggtcagccagcaag gaagagagcgagaaggagaaacccgaggaggacaacccagagatgggcttcttctcggtg accacagtgcggacggccctcctggccctccgctacaacgtgatgatgctgatgaaggtg ctttccatgaaaagccttaagaagcagatgaagaagatgaaaaagatgacggtgaaggac atggtgaccaccctcgtcgccttctactggagcctgctcatgggcctcctccactttgcc tttagcgtgtcgcgtggcttcttccgcattgtctacagcaccttcctgggcgggagcctg gtggagggggccaagaccatgaaggtggccgacctgctggccaacatgcccgaccccacc caggacgaggtccgcggggaaggggaggaggccgagaagaggcacccggacaagtcctcg gccgaggaggacctggcagacctggcggtcaatattgaggacacggacctcctgtcagac atttttgggcttgacctgaggagagaaggggggcagtataagttgatgcctcacaacccc aacgccagcctgacggatttgctcaacagcccggtgccccctccgccgactccctcacct gagcttcggaggcggaatcaggggaaaggctccacagacgaagacggagaaggaaaagaa gagagccaatctgaaccagaaaaggcagagggagagaatggggaaaaagatgtcaagcca aaggatgacaagccaaaacagaaagtcaggcagcatcacacctccaaatctgaagagcca gagctacaggagtctgccttctggaagaagatcattgcttatcagcggaaactgctcaat tattttgcccggaacttctacaacatgagaatgctggctctgttcgttgcctttgcgatc aacttcatcctgctcttctacaaggtgtccacatcgtccgcggtggtggaggagaaggag gtggtgtacagcgggccatcggacaccagcgtgcggtggagcccggtggagggcgtgccc caccgcacggtgacagtgcacttcgtcctggaggagagcagtgggtacatggagcccacc ctccgcatcctggctatcttgcacactgtcatatccttcttctgcatcataggctattac tgcttaaaggtcccattggtgatatttaaacgggagaaggaggtagccaggaagctggag tttgacggactctatataacggagcagccatcagaagacgacattaaagggcaatgggac aggcttgtaattaacacacagtcattcccaaataattactgggataaatttgtgaaaagg aaggtgatggacaaatatggagagttctacggacacgaccgcatcagtgagctgctggga atggataaggctgccttagacttcagcgatgcccacgagaagaagaaacccaagaaagac agctcattagttgccgtactgaactccgtcgatgtcaaatatcaaatctggaagttggga gtggtcttcacagacaattccttcctctacctggcctggtacatgaccatgtccatcctg ggccactacaataatttcttcttcgccgcccacctgctagacatcgccatgggatttaag accctgcgcaccatcctgtcctcggtcacccacaatggcaagcagctggttctgacggtg gggctactagccgtggtggtatacctgtacactgtggtggccttcaacttcttccgcaaa ttctacaacaagagtgaggacggagaatctccagacatgaagtgtgacgacatgctgact tgctacatgttccacatgtatgtaggcgtgcgagctggaggaggcatcggcgaccagatt gaggatccagcgggagacgagtacgagatttaccggatcatcttcgacatcacgttcttc ttcttcgtcatcgtcattctgcttgccatcattcagggcttaataattgatgccttcggt gaactacgagaccagcaagagcaagtgaaagaggacatggagacgaaatgtttcatctgc ggtatcgggaacgactatttcgacacggttccccacggcttcgagacgcacaccctgcag gagcacaacttggcaaactatctattttttgtgatgtatctcattaacaaagatgaaaca gagcacacaggccaggagtcgtatgtctggaagatgtaccaggaacgctgttgggaattc tttccagctggagactgtttccgcaaacaatatgaagaccagctcaactga

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