KEGG   Amycolatopsis coloradensis: LCL61_00155
Entry
LCL61_00155       CDS       T10308                                 
Name
(GenBank) amino acid adenylation domain-containing protein
  KO
K16428  nonribosomal peptide synthetase CepA
Organism
acor  Amycolatopsis coloradensis
Pathway
acor01055  Biosynthesis of vancomycin group antibiotics
Brite
KEGG Orthology (KO) [BR:acor00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01055 Biosynthesis of vancomycin group antibiotics
    LCL61_00155
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins [BR:acor01008]
    LCL61_00155
Polyketide biosynthesis proteins [BR:acor01008]
 Nonribosomal peptide synthetase (NRPS)
  Linear NRPS
   Vancomycin synthetase
    LCL61_00155
SSDB
Motif
Pfam: AMP-binding Condensation PP-binding AMP-binding_C
Other DBs
NCBI-ProteinID: WYW13956
LinkDB
Position
36436..42621
AA seq 2061 aa
MSSAAQAAPTVLDLFARQVGRAPGSVAVADGDRLLTYRELDELAGRLSGRLVARGARRVA
VMLDRSADLLVALLAVWKAGAAYVPVDASYPAARVAFMVADSGASLMLCSAATRDSVPDG
IEAIVVTDEAGDVAVAPASPEDLAYVMYTSGSTGKPKGVAVPHSSVADLVGDPGWAMEPD
DAVLMHAPHSFDASLCEIWVPLVSGARVVIAAPGPVDARRLREAVAAGVTRAHLTAGSFR
AVAEEAPESFAGLREILTGGDLVPAHAVDRVRHAAPGARIRHLYGPTETTLCATWHVLEP
EDDPVPVLPIGRPLAGRQARVLDDSLRPVAPDVVGELYLSGAGLADGYLDRAGLTAERFV
ADPFAPGKRMYRTGDLAKWTPDGELFFAGRVDDQVKIRGFRIEPGEVEAAMTAQPDVHEA
VVVPIDGRLIGYVVADVDPALVRERLQAVLPDYLVPAVVMAVAALPLTGNGKVDRAALPA
PDFTAKADGREPATEAERVLCGLFAEVLGIERAGVDDGFFELGGDSILAVRVAARAAKAG
LLVTPSQIFGERTPARLAAVAGAVEDRPVDGPLVELTAEDETELAAAVPDAVEVWPLAPL
QAGLLFQTTLDDQGPDIYQTQWIVELTGPLDVARLRSTWEAVFARHPELRLTFHRLASGK
AVQAVAGRVELPWREVDLTGASDVEEAVKALSVEEQRDRFDLAKAPLFRLVLIKTGEDRH
RLLVVNHHILTDGWSVAVILNEVSAAYTSGGFPDRTAASYRDYLAWLDRQDKDAARAAWQ
AELSDIDVPALVAKSDSATDYDYRVTHLASELYTRLTAFARDHGLTLNTVVQGAWALVLA
RLARRTDVVFGTTVACRPAELPGVESMPGLMMNTIPVRVSLDGKQSVVDMLTALQRRQVE
LMPHQHLGLTEIQKTAGPGAMFDTLLVFENYPRDFADQFSYLGTVEGTHYPVTVGVIPGE
EFRIQLAYWRGQIDEAVADSLLDWFAGALGAIVEDPSALVGRTGMGEIPLPRWAPALIDG
EPLPELIGRMAAERPDAVAVTDGEGDLTYAELWDRATRFAAVLRAAGVDRERRVGLVAGR
SAWWLIGMLGVSLAGGVFVPVDPAYPAERVKLIFGSSDPMLVVCQGKTRDAVPEEFADRL
VVLDELGLSAAPDVVLPKVGMRDAAYVIYTSGSTGTPKGVIVTYSGLGNLAMAHIERLAV
TPSSRVLQFAALGFDTIVSEVMMALLSGATLVMPPDEDLPPQASLSDTLERWDVTHVKAP
PSVLATVDVFPAGVETVTAAGELCPPGLVDRLSADRRMLNAYGPTETTICATVSMPLAPH
GEVIPFGGPIAGVRGYLLDAFLRPLPRGVVGELYLAGIGVARGYLGRAALTSERFVADPF
VPGERMYRTGDLAYWTDEDELVSAGRADDQVKIRGFRVEPREIEFALSDNPRVTQATVTV
RQGRLVAYVSPGDVDPEALRTELAERMPAYMVPAAVMALDVLPLTAHGKIDRKALPEPDF
SSKTVGREPATEAERILCEVFAEVLGLARVGVEDSFFELGGDSISSMQVASRARRDGISL
TPKQVFEHRTPERLAQLVALAPRQESGRATDGIGEVELTPVMRLFGDGVAAPGFAQWMVL
GAPADLTEETLTAGLSAVLDTHDMLRARVVDGRLLVGERGAPATFTRVKVEGPLDESAAA
REAVARLDPAAGVVVQIVWLDAGADRVGRLIVVAHHLVVDGVSWRVLASDLRAACEAVAA
GRKPGLEPVAVSFRRWAGLLQEWAVSAERVAELPAWQAILGHEEKPGRAPAGKVRSKSWV
VPSAQTSVLAGRAPVVFHCGVHEVLLAGLAGAVARWSASDSVLVDVEGHGRHPAEGMDLS
RTVGWFTSTHPVRLDVSGIDLAGVLAGDAAAGTLLKAVKEQSRAVPGDGLGYGLLRHLNA
ETEPLLAALPSARIGFNYLGRFAAGESGDVRAWQQVGEIGGSIDADMRLPHALDVNVIVQ
DLPDGPELILMLEWSDDVFDEAGIARLVQELLDVLSGLASQAEDPAAGGHTASDFGLLEL
DQDEIESFEALAAELSEGRAS
NT seq 6186 nt   +upstreamnt  +downstreamnt
atgagttccgcagcgcaggccgcaccgacggtgctcgatctcttcgccaggcaggtgggc
cgggcgcccggctcggtggccgtggccgacggggaccggctcctcacttatcgggagctc
gacgagctggcgggcaggctgtccggccggttggtcgccaggggcgcccgccgggtcgcg
gtgatgctggaccgctcggcggatctgctggtggcgctcctcgccgtctggaaggcgggc
gcggcgtacgtgccggtggacgcctcgtatcccgcggcgcgggtggcgttcatggtcgcg
gattcgggtgcgtccctgatgctgtgctcggccgcgacgcgcgacagcgtcccggacggg
atcgaggcgatcgtcgtcacggacgaagcgggtgacgtcgcggtcgctccggcgagcccg
gaggacctggcgtacgtgatgtacacgtccggctcgacgggcaagccgaagggcgtcgcc
gtcccgcattccagcgtcgcggacctggtgggcgatcccggctgggcgatggaacccgac
gacgcggtcctcatgcacgcgccgcattccttcgacgcgtccctgtgcgagatctgggtg
ccgctggtgtcgggtgcccgggtggtgatcgccgcgccggggccggtggacgcccgccgg
ctgcgggaggcggtcgcggccggggtgacgcgggcgcatctcaccgcgggcagtttccgt
gcggtggcggaggaagcgccggagtcgttcgcggggctgcgcgagatcctgaccggcggg
gacctggtgcccgcgcacgcggtggaccgggtgcgccacgccgcgcccggcgcgcggatc
cggcatctgtacgggccgacggaaacgacgctgtgcgccacgtggcacgtgctcgaaccg
gaggacgacccggtgccggtgctgccgatcgggcgtccgctcgccggacggcaggcccgg
gtgctggacgactcgctgcggccggtcgccccggacgtggtcggcgagctgtacctgtcc
ggtgccgggctggccgacggctacctcgaccgggccgggctgacggcggagcggttcgtg
gcggatccgttcgcgccgggcaagaggatgtaccgcaccggtgacctcgcgaagtggaca
ccggatggcgaactgttcttcgcgggccgcgtcgacgaccaggtgaagatccgcgggttc
cggatcgaacccggtgaggtcgaagccgcgatgaccgcccagccggacgtccacgaggcc
gtcgtggtgccgatcgacggccgcctgatcggttacgtggtggcggacgtggatcccgcg
ctcgttcgcgagcggcttcaggcggtcctgcccgactacctggtcccggccgtggtgatg
gcggtggccgcgctgccgctgaccggcaacggcaaggtggaccgggcggcgttgcccgca
cccgatttcacggcgaaggccgacggacgggaacccgccaccgaggcggagcgtgtcctt
tgtggactgttcgccgaggtgctcggcatcgagcgggcgggtgtcgacgacggcttcttc
gagctgggcggggattcgatcctcgcggtgcgcgtcgcggcccgggcggcgaaggccggt
ctgctggtgacgccgtcgcagatcttcggcgagcggactcccgcgcggctggccgcggtg
gcgggcgccgtggaggaccggcccgtcgacggccccctggtcgagctgaccgcggaagac
gagacggaactggcggccgcggtccccgacgccgtcgaggtctggccgctggcgccgctt
caggcgggtctgctcttccagacgaccctcgacgaccagggccccgacatctaccagacc
cagtggatcgtggagctgaccgggccgctggacgtggccaggctgcggtcgacgtgggag
gcggtcttcgcccggcatcccgaactccggctgaccttccaccggctcgcgtcgggcaag
gcggtgcaggccgtcgccggacgcgtcgagctgccgtggcgcgaggtcgacctgaccggc
gcgagcgatgtcgaagaggctgtcaaggcgctgtccgtggaggaacagcgggaccggttc
gacctcgccaaggcgccgttgttccggctcgtgctgatcaagaccggcgaggaccggcat
cgactgctggtcgtcaaccaccacatcctgaccgacgggtggtcggtggcggtgatcctc
aacgaggtgtcggcggcctatacctccggtggcttcccggaccggacggccgcctcgtac
cgcgactatctggcgtggttggacaggcaggacaaggacgcggcgcgggcggcctggcag
gcggagctgtcggacatcgacgtgcccgcgctcgtcgccaagtcggactccgcgacggac
tacgactaccgcgtcacccatctggcgtcggagctctacacccggctgaccgcgttcgcc
cgcgaccacgggctgacgctcaacacggtggtgcagggcgcgtgggcgctggtgctggcg
cggctcgcgcggcgaaccgacgtcgtgttcggcaccacggtcgcctgccgtcccgccgaa
ctccctggcgtcgagtcgatgccgggactgatgatgaacacgatcccggtgcgggtctcg
ctggacggaaagcagtccgttgtggacatgctcaccgctctccagcggcgccaggtcgag
ctgatgccgcatcagcatctggggctgacggagatccagaagacggccggacccggcgcg
atgttcgacacgctgctggtgttcgagaactacccgcgggacttcgccgaccagttctcg
tatctgggcacggtcgagggcacccactacccggtgacggtcggggtgatcccgggcgag
gagttccggatccagctcgcctactggcgcgggcagatcgacgaggccgtcgccgactcc
ctgctggactggttcgccggagccctcggcgcgatcgtcgaggatccgtccgcgctcgtc
ggacggaccgggatgggcgagatcccgttgccccgctgggcacccgcgctgatcgacggc
gagccgctgccggagctgatcgggcggatggcggccgagcggccggacgcggtggcggtc
acggacggcgaaggcgacctgacctacgcggaactgtgggaccgggcgacgaggttcgcc
gccgtgctgcgggcggcgggcgtcgaccgggagcgccgcgtcggactggtggccggacgg
tccgcgtggtggctgatcgggatgctcggggtgtcactggcgggcggcgtcttcgtcccg
gtggatcccgcgtacccggccgagcgggtgaagctgatcttcggcagctcggatccgatg
ctggtggtgtgtcagggaaagacgcgcgacgcggtgccggaggagttcgcggaccggctc
gtggtgctcgacgagctgggcctttcggcggccccggacgtggtcttgccgaaggtgggg
atgcgcgacgcggcgtacgtgatctacacgtcgggatcgacgggaaccccgaagggcgtg
atcgtcacttactcgggcctgggcaacctggcgatggcgcatatcgaacgcctggccgtg
acgccgtcgtcccgcgtcctgcagttcgcggcgctcggcttcgacaccatcgtgtccgag
gtgatgatggcgttgctttccggggcgacgctggtgatgccgccggacgaggatctgccg
ccgcaggcgtcgttgagcgacacgctggagcggtgggacgtcacgcacgtgaaggctccg
ccgtcggtgctggccaccgtcgacgttttcccggccggggtcgagacggtgaccgcggcg
ggagagctctgcccgccgggactggtggaccggctctcggccgaccgccggatgctcaac
gcctacgggcccaccgagaccacgatctgcgcgacggtgagcatgccgctggcgccgcac
ggcgaggtgatcccgttcggcgggccgatcgccggggtgcgcggctatctgctggacgcg
ttcctgcgcccgttgccgcgcggcgtcgtcggcgagttgtatctggcgggaatcggtgtg
gcgcgggggtatctgggtcgcgcggcgctgacgtcggagcggttcgtcgcggatccgttc
gtgcccggcgagcggatgtaccggaccggcgacctagcctactggacggacgaggacgag
ctggtgtccgccggccgggccgacgaccaggtgaagatccgcgggttccgggtcgagccg
cgcgagatcgaattcgcgctgtccgacaaccctcgggtcacgcaggccacggtgacggtt
cgccaagggcgtctggtcgcctacgtgtcgccgggcgacgtcgacccggaggcgctgcgg
accgaactcgccgagcggatgccggcgtacatggtgcccgcggcggtgatggcgctggac
gtcctgccgctgaccgcgcacgggaagatcgaccggaaagcgttgcccgaaccggatttc
tcgtcgaagacggtcggcagggagccggcgaccgaggccgagcggatcctgtgcgaggtc
ttcgccgaggtgctcgggctggcgcgggtcggggtcgaggacagtttcttcgagctgggc
ggagattcgatctcgtccatgcaggtcgcgtcccgagcgcgtcgcgacggcatctcgctg
accccgaagcaggtgttcgaacaccggactccggaacggctcgcgcagctggtggcgctg
gcgccgcggcaggaatcgggcagggccaccgatggcatcggtgaagtcgagctgacgccg
gtgatgcggctgttcggggacggcgtcgcggcgccgggcttcgcgcagtggatggtcctg
ggcgccccggcggatctgacggaagaaacgttgacagccgggctctcggcggtgctggac
acgcacgacatgctgcgggcacgggtagtcgacggacggctgctggtcggcgagcgcggc
gctcccgcgacctttacccgggtgaaggtcgagggcccgctggacgagtccgccgcggcg
agggaggccgtcgcgcggctggatcccgccgcgggcgtggtcgtccaaatcgtgtggttg
gacgccggagcggaccgggtgggccgtctgatcgtggtggcgcatcacctcgtggtcgac
ggggtctcgtggcgagtcctggcgtcggatctgcgagcggcgtgcgaagccgtcgccgcc
ggccggaaacccggactggagccggtggcggtgtcgttccgccgatgggcgggtctgctc
caggagtgggcggtctccgccgagcgggtcgcggaactcccggcgtggcaagcgattctc
gggcacgaggaaaagcccggacgtgccccggcggggaaggtgcgctcgaagtcatgggtg
gtgccttcggctcagacgtcggtgctggccgggcgggcgccggtggtgttccactgcggc
gtgcacgaggtcctgctggccgggctcgcgggagcggtggcccggtggagtgcgtcagac
tcggtgctggtggacgtcgagggccatggtcgtcatccggccgagggaatggacctgtcc
aggacggtgggctggttcaccagcacacatccggtgcggctcgacgtctcggggatcgat
ttggccggggtgctcgccggtgacgcggcggccgggaccttgctgaaggcggtgaaggaa
cagtcgcgcgcggtgcccggcgacgggctcgggtacgggttgctgcgccatctcaacgcc
gagactgagccgctgctggcggcgctgccgtcggcgcgcatcgggttcaactacctcggc
cggttcgccgccggtgagagtggcgatgtgcgggcgtggcagcaggtcggcgagatcggc
ggctcgatcgacgcggacatgcggctgccgcacgcactcgacgtcaacgtgatcgtccag
gacctgccggacgggccggaactgatcctcatgctcgaatggtcggacgacgtgttcgac
gaagccggaatcgcacgactggtccaggagttgctggacgtgttgtccggactggcttcc
caagcggaagaccccgccgcgggcgggcacaccgcatccgatttcggtctcctcgaattg
gaccaggacgagatcgagagcttcgaagcattggcagcggaactcagcgaaggccgggca
tcgtga

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