Anopheles coustani: 131271944 Help Entry 131271944         CDS       T10908                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism acos  Anopheles coustani Brite KEGG Orthology (KO) [BR:acos00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:acos04040]     131271944    04990 Domain-containing proteins not elsewhere classified [BR:acos04990]     131271944 Ion channels [BR:acos04040]  Voltage-gated cation channels   Ryanodine receptor    131271944 Domain-containing proteins not elsewhere classified [BR:acos04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    131271944 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR Ins145_P3_rec SPRY MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 TPR_TTI1_C GET2 Motif Other DBs NCBI-GeneID:  131271944 NCBI-ProteinID:  XP_058129517 LinkDB All DBs Position 3:complement(64097068..64129966) Genome browser AA seq 5095 aa AA seqDB search MAEAEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLS QCVFVIEQALSVRALQELVTAAGSETGKGTGSGHRTLLYGNAILLRHNNSDMYLACLSTS SSNDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLHTTKE NDLSIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTWSVDSG QNIVVYEGGSVMSQARSLWRLELARTKWAGGFINWSHPMRIRHLTTGRYLGVNENNELIL MTRDQATTSQTAFVLRLEKDDQKVVLEDKDLEIIGAPIIKYGDSTVIMQHYESGLWVSYK SYETKKKGVGKVEEKQAILHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTKFISGLE TLQENRRHSIFLQTVNLGEMVMCLEDLINYFAQPEDDMEHEEKQNRLRALRNRQDLFQEE GVLNLILEAIDKINVISSQGFLASFLANDESGQSWDMISGYLYQLLAAIIKGNHTNCAQF ANSNRLNWLFSRLGSQASSEGSGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEKHGRD PKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTGLVDHVASIRPNIFVGRVEGS AIYQKWYFEVTMDHIEQMTHMTPHLRIGWANTAGYVPYPGGGEKWGGNGVGDDLFSYGYD GVHFWSAGRRTCVVPREVTEPYIKKGDVIGCTLDLSVPVIRFTFNGEPVQGCFTDFNLDG MFFPVMSCSSKLSCRFLFGGDNGRLKFNPPPGFSPLVQCLMPHQNLSLDPCFYFGNLNKN VLAGPWLVEDDSAFVPKPVDTSTVTLPSSVETIRDKLAENIHEMWALNKIEAGWTWGERR DDVYRIHPCLTSFEKLPSAEKRYDCQLAVQTLKTILSLGYYISVDKPPARIRPIRLPNDP YMQGNGYKPAPLDLSAAVLTPKMEELVDQLAENTHNLWAKERIQQGWTYGLNEDSENLRS PHLVPYSKVDEAIKKANRDTASETVRTLLIYGYNLDPPTGEANEALAAEALRQKFAAYRT YRVERTYAVTSGKWYFEFEVLTAGPMRVGWARADCNPGTMLGSDDSTWAFDGYNARKIHL HTLEDFGRRYKIGDIIGCFINVHEKSISFSLNGELLMDALGGETTFADVNAPEGVGFVPA CTIGIGQKARVVYGQDVDSLKWFTTCGLQEGYEPFCVNMKRPVTHWYTKDQPIFENTDEI PDGKIDVTRIPGGADTPPCMKISHNTFETMEKANWEFLRLSLPVTCANTFISESEKMRRW EEIRIRQHRLMTEVDHSAPAHFDHIMRSGFTMNDIKGLHRNYSEDAAEADDMLRNGPRRP SRHAPRGGLSPPGIEINGEATSDGELNAYSDNELEGAGDDRKKRGRSPFRLFGKKRDQSK DKLKDRRTPEPEPRKSNLKVAQRSQAMRLSNSDLRSQPPMTPERKGGMGSPQVESFGNEV YDADCLRLINEYFYGVRIFPGQDPTHVYVGWVTTQYHVHSKEFGQNKVRHAAIYVEDETG KTVEIVNRQSCYMVRADELFNEVTQDSSGKGASQGMFVGCFVDTATGTIRFTCEGKETSH VFLMEPDTKLFPAIFVEATSKEILQIELGRTPTTLPLSAAVLPTSDKHINPQFPPRLKVQ CLKPHQWARVPNTALQVHALKLSDIRGWSMLCEDPVSMLALHIPEEDRCIDILELIEIDR LLQFHAHTLTLYSALCYQSNYRAAHALCSHVDQKQLLYAIQSEYMSGPLRLGFYDLLISL HLESHATTMEVCKNEYIIPLGSDLRELYTDPEMCHSLRSLQTLSVRPEMNMTEIAEPIPA IDSLYSPRFPLEVVREFVMSALQEAVLINQVHNRDPIGGSNENLFLPLIKLIDRLLLVGV ITNEDVEKLLIMIDPETWDPLFEKEGKDEHRKGLLTMKMAEGAKLQMCYLLHHLYDVQLR HRVESIISFAHNYVGDLQQDQLRRYIEIKQSDLPSAVAAKKTREFRCPPREQMNAILGFK NLEEEDLENASCGSDLRNRLIEFHERLMGKVSLNALQEPEEPEADKAEDGRPGALKKVYN FINAVKELEEDPKEPVEEEKKTPEEVFRKVLIKQIVSWAEESQIENPKLVREMFSLLVRQ YDTIGELIKALNKTYVINAKTKSDVANMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVN NHTFFQHPDLIRILRVHENVMAVMMNTLGRRAQAQSDAPVQTAEGEESAPKEKDTSHQMV VACCRFLCYFCRTGRQNQKAMFDHFDFLLENSNILLSRPSLRGSTPLDVAYSSLMENTEL ALALREHYLEKIAIYLSRCGLQSNSELVERGYPDLGWDPVEGERYLDFLRFCVWVNGESV EENANLVIRLLIRRPECLGPALRGEGEGLLKAIMEANKMSERISERRKMMDETEGTIAGL NFTHPLPEGDDDEDYIDTGAAILCFYCTLVDLLGRCAPDAAVIEQGKNESLRARAILRSL VPLEDLQGVLSLKFTLTNPAIGEDRPKSDMPSGLVPGHKQSIVLFLERVYGIETQELFYR LLEDAFLPDLRAATMLDRSDGSESDMALSMNRYIGNSILPLLIKHSKFYNEAENYASLLD ATLHTVYRMSKNRMLTKGQREAVSDFLVALTSAMHPAMLLKLLRKLTIDVSKLSEYTTVA LRLLTLHYERCAKYYGTTGGGQASQFGASSDEEKRLTMLLFSNIFDSLSNMDYDPELFGK ALPCLIAIGCALPPDYSLSKNSDDDLYGKPTGGGPDQPHYNPQPIDTTAVQLTNDLNQIV QKFSEHYHDAWASRKLENGWTYGDQWSDSSKTHPRLKPYNTLSENERERYREPVRESLKA LLALNWRIEHSEGDVPLSNRGSMRRQSKPNLGDTGSPFNYNPHPVDMTNLTLSREMQNMA ERLAENSHDIWAKKKNEELNQCGGAIHAQLVPYDLLTDKEKRKDRERSQEFLKYLQYQGL KLHKPSRGQTEEPGMSTAAIELRFAYSLLEKLISYSDRATINMKLLKPSTTFSRRSSFKT CSRDIKFFSKVVLPLMEKYFSSNRNYFIAIATATNNVGAASLKEKEMVASLFCKLASLLR HRLTAFGADVRITVRCLQVLVKSIDAKSLVKNCPEFIRTSMLTFFNNTADDLGQTIVNLT DGKYDRLRGTHLKTSTSLAYVNQVILPVLTSLFDHLAACDYGSDLLLDEIQVASYKILSA LYTLGTDMSLTRDRKYLKTELERHKPALGSCLGAFSSCFPVAFLEPHANKHNPFSLLNRI ADTSLEAQDIMTKMESSMPTLESILAEVDQFVESEKTYQEAQHIIDVILPLLCSYLPFWW NQGPDNVSPQTGNHVTMVTAEHMNHLLKNVLKMIRKNIANENAPWMTRIATYTQQIIINS SEELLKDVFLPLAERVKKRCDSMFHKEESLRGFLKSSTDDTSQIEAQIQEDWQLLVRDIY SFYPLLIKYVDLQRNHWLKDNVSEAEELYNYVAEIFNVWSKSQYFLKEEQNFISANEIDN MALIMPTATRRSAAISGDVPASGGKVKKKKRSRDKKRDKDKEIQSSLMVACLKRLLPVGL NLFAGKEQELVQHCKDRYLKKMPEYEVIEFARTQLTLPDKLDPADEMSWQHYLYSKLGKK EQIVADSLEKSDKKPENKIEDTVERIVAMAKVLYGLHMACRPIAKGLNWTQVLSQARRKM AVACLRAKPMYRLSRHRACNIFGRSYSELWLEDENVGQEVMIEDLTQTFEDAEKKKKDEE EEEGKPDPLTQLVTTFCRGAMTERSGALQEDPLYMSYANIVARSCGEEEEEGGDEEEGAG EDEGGASIHTMQKLMEQEMEKQKLLFHQARLANRGVAEMVLLHISASKGLPSEMVMRTLE LGIAVLRGGNIDIQMGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEGLGVG SDGAAGEKNMHDAEFTCALFRFIQLTCEGHNLDWQNYLRTQAGNTTTVNVVICTVDYLLR LQESIMDFYWHYSSKELIDPAGKANFFKAIGVASQVFNTLTEVIQGPCTQNQQALAHSRL WDAVGGFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMV DTLVESASNVELILKYFDMFLKLKDLTSTPSFMEIDANGDGWIMPKDFREKMEQQKSYTP EEIDFLLACCETNHDGKIDYIGFVDRFHEPAKEIGFNLAVLLTNLSEHMPNEPRLARFLE TAGSVLNYFESFLGRIEIMGSSKRIERVYFEIKEANIEQWEKPQIKESKRAFFYSIVTEG GDKEKLEAFVNFCEDAIFEMTHASGLMASDDDGATVRRDQAFTYISEEEEERAAQDPIKR TIQAIKDGLSYSMYMISPSNIKHQITVLQSKSFPEIIVGFFKMIFYAFYYSGFGVSVVIR YLVNILMSLMRGPAQEEEEPIPEAEPSLRALPPLPLEEPPGTVQAFGLDISKEENGQYRM APHESPALSPSSSIEETGESSPEDGANELTGEGVAPGEQMTLVDLLGGEAAKRAAQERTE AQKAQEATLASIEAESKKASAETKEPAAVHQIDFSKYTKKCVSYLARNFYNLKYVALVLA FCINFMLLFYKVTTLGDDEDAEGSGEGLMGLGSGMGSGLGILETGSGGGADGGSGDGEGE EEDPLEKVHVDEDFFYMEHVLRVAAILHSLVSLAMLIAYYHLKVPLAIFKREKEIARRLE FDGLFIAEQPEDDDIKSHWDKLVISAKTFPVNYWDKFVKKKVRQKYSETYDFDSISNLLG MEKTAFAAQEANEGGGFFHFIANIDWRYQIWKAGVTITDNSFLYSLWYFTFSVMGNFNQF FFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRKFYIQED DDGEEGDRKCHDMATCFVFHLYKGVRAGGGIGDEIGDPDGDEYEVYRILFDITFFFFVIV ILLAIIQGLIIDAFGELRDQLESVKEDMESNCFICGIGKDYFDKVPHGFDTHVAQEHNLA NYMFFLMHLINKPDTEYTGQETYVWNMYQQRCWDFFPVGDCFRKQYEDELGGGGS NT seq 15288 nt NT seq  +upstreamnt  +downstreamnt atggcagaagcagagggaggatccgagcaggatgatgtttcattcctgcggacggaagac atggtctgcctgtcctgcacggcaaccggcgagcgtgtgtgtctggcggccgaaggcttc ggcaaccggcactgcttcctggagaacatcgcagacaagaacatcccgccggacctatcg cagtgcgtgttcgtcatcgagcaggccctctcggtgcgcgccctgcaggagctggtgacg gccgccggctcggaaacgggaaaaggtaccggatctggtcaccggacgctgctttatggc aatgctatcctgctgcgtcacaacaacagcgacatgtatcttgcatgcctgtcgacgtct tcctctaacgataagctgtcgttcgatgtcggtctgcaagagcacagccagggtgaggcc tgttggtggacggttcatccggccagcaagcagcgctcggaaggtgaaaaggttcgcgtc ggtgacgatctcattctggtgtccgtcgccaccgagcgttatctgcacacgaccaaagag aacgatctgtcgatcgtcaacgcgagcttccacgtgacgcactggagcgtacaaccgtat ggtaccggtatttcgcgcatgaagtacgtcggctacgtgttcggtggcgacgtgcttcgc ttcttccacggtggcgatgaatgtttgacgattccgagcacctggagcgtagactcaggg cagaatattgtcgtgtacgaaggaggctctgtaatgtcacaagctcgatcgctgtggcgt ctggagctggcccgtaccaagtgggccggtgggtttatcaactggtcgcacccgatgcgc atccgccatttaacgactggccggtacctcggcgtgaacgagaacaacgagctcatcctg atgacgcgtgaccaggcgactacttcgcagaccgctttcgtgctgcggctcgagaaggac gaccagaaggtggtgctggaggataaggatctggaaatcatcggcgcaccgatcatcaag tacggtgactcgacggttatcatgcagcactacgagtcgggcctgtgggtcagctacaag agctacgagacgaagaagaagggcgtcggtaaggtcgaggaaaaacaggccatactccac gaggaaggcaagatggacgatgggttggacttttcacgctcgcaggaggaggaatcgcgt acagctcgcgtcattcgtaaatgtagcagcttgttcaccaagtttatcagtggccttgaa acgctgcaggagaatcgccgtcattcgatattcctgcaaacggtcaacctcggtgagatg gttatgtgcctggaggatctgatcaactacttcgctcagcccgaggatgacatggagcac gaggagaagcagaaccggctgcgcgcgttgcgcaatcggcaggacctgttccaggaggaa ggtgttctcaacctgatcctggaggcgatcgacaaaatcaacgtcatctcgtcgcagggc ttcctggcgtccttcctggccaacgacgaaagtggccaaagttgggacatgatttccggc tacctctaccagctgctggctgccattatcaagggcaaccacacgaactgcgctcagttt gccaactcgaaccgtctgaactggctgttctctcgactcggttcgcaggcgtctagcgag ggctcgggaatgctggatgtactgcactgcgtgcttatcgactcaccggaggcgctgaac atgatgcgtgacgaacatatcaaggtgatcatctcgctgctggagaagcacggccgcgat ccgaaggtactggacgttctgtgctcgctgtgcgtcggtaacggcgtggcggtacgctcg tcgcagaacaacatctgtgactttctgctgccaggcaaaaatctactcctgcagaccgga ctcgtcgatcatgtggccagcatccggccgaacatctttgtcggtcgcgtcgaaggttcc gccatctatcagaagtggtacttcgaggtaacgatggatcacatcgagcagatgacgcac atgacgccccatctgcgcatcggttgggccaacacggccggttacgtgccgtacccgggc ggtggcgagaagtggggcggaaacggagtcggtgacgatctcttttcgtacgggtacgac ggtgtacacttctggtctgccggacggcgcacctgcgtcgtgcctcgggaggttacggag ccgtacatcaagaagggtgacgtcatcggctgcacgctagatcttagcgtcccggtaatt cgctttacgttcaacggtgaaccggtgcagggttgcttcaccgatttcaacctggacggc atgttcttccccgtcatgagctgctcgtcgaagttgagctgtcgcttcctgttcggcggc gataacggacgtctgaagttcaacccgccgcccggtttttcaccgctcgtgcagtgcctt atgcctcaccagaacctcagtctggatccgtgcttctacttcggcaatctgaacaagaac gtcctggccggaccctggctcgtggaagacgattctgctttcgtgccgaaaccggtcgat acgtcaaccgtaacgttgccctcgtcggtcgagacgatccgggacaagctggcggagaac atccacgaaatgtgggcgttgaacaagatcgaagccggttggacctggggcgaacggcgt gacgacgtgtaccgcattcatccgtgtctgacatcgttcgagaagctgccgtccgctgag aagcgctacgattgccagctagccgtgcagactctcaagacgatcctctcgctcggctac tacatctcggttgacaaaccgccggcacgcatccgtcccatccgcctgccgaacgacccg tacatgcagggcaacggctacaaaccggcaccgctggatctcagcgcggccgtgctcacg cccaagatggaggagctggtggaccagctggccgaaaacacgcacaacctgtgggccaag gagcgcattcagcagggttggacgtacggtttgaacgaggactcggagaacttgcgcagc cctcatctggttccgtactcgaaggtggacgaagcgatcaagaaggccaaccgcgataca gcctccgagacggtgcgcacgctgctcatctacggctacaacctggatccaccgactggc gaggccaacgaggcgctagccgccgaggccctgcgtcaaaagttcgcagcctaccgtacg taccgtgtcgagcggacgtatgcggtcacttccggcaagtggtacttcgagtttgaagtg ctgacagccggtccgatgcgggttggttgggctcgagccgactgcaaccctggcacgatg ctgggaagcgacgactctacgtgggctttcgatggatacaatgcacgcaagatccacctc catacgctcgaagactttggtcgtcggtataagattggggacatcatcggttgcttcata aacgtccacgagaagagcataagtttctcactgaacggtgagctgctgatggatgccctc ggcggggagactacgttcgccgacgttaacgcaccggaaggtgttggatttgtgccggcg tgcacgatcggtatcggccagaaagctcgcgtcgtttacggacaggatgtggactcgctg aaatggttcaccacctgcggtttgcaggaaggctacgaaccgttctgcgtgaacatgaaa cgcccggtcactcactggtacacgaaagatcaaccaatcttcgagaacaccgatgaaatt ccggacggtaagatcgacgtcactagaatcccgggcggagcggatacgccgccctgcatg aaaatctcgcacaacacgttcgagacgatggaaaaggcgaactgggagtttctgcgactt tcgctgccagttacgtgcgcaaacacgtttatcagtgagtcggaaaaaatgcgccgctgg gaggagattcgcatccgtcagcaccgtttgatgacggaggttgaccactcggcaccggcg cacttcgaccacatcatgcgtagcggattcaccatgaacgacatcaagggtcttcaccgg aactactcggaggacgccgccgaagcggacgatatgcttcgcaacggacctcgccggcct tctcgtcacgcgccgcgtggtggcctcagcccacccggcatcgagatcaacggcgaagcc acgagtgacggcgagctgaacgcgtactcggacaacgaactcgaaggagccggtgacgat cgcaagaagcgtggccgcagcccgttccgcttgttcggcaagaagcgcgaccagagcaag gacaagctgaaggaccggcgcaccccggagccggaaccacgcaagagcaacctgaaggtg gcccagcgaagccaggctatgcgtctgtcgaacagcgatctgcgttcgcaaccaccgatg acgccggagcgcaagggaggcatgggcagcccgcaggtggaatcgttcggcaacgaagtg tacgatgccgactgtttgcgcctcatcaacgaatacttttacggcgtgcgcatcttcccc ggtcaggacccgacgcacgtgtacgtcggctgggtaacgacacaataccacgtccacagc aaggagttcggacagaataaggtgcgccacgcggcgatctacgtcgaagacgagactggc aagacggttgagattgtaaaccgccagtcgtgctacatggtgcgtgcggatgaactgttc aacgaagtcacgcaggactcgtctggtaagggagcctcgcagggtatgttcgtcggatgc ttcgtcgacacggccaccggtacgatccggttcacgtgcgagggtaaggaaacgtcgcac gtcttcctaatggagcccgacaccaagctcttcccggccatcttcgtcgaggccaccagc aaggagattctgcagatcgagctcggtcgtacaccgaccacgttgcctctgtcggccgca gttctgccaacgagcgacaagcacatcaacccgcagttcccaccgaggctgaaggtacaa tgtctgaagccgcaccagtgggcccgtgtgcccaacaccgccctacaggtgcacgccctc aagctctcggacatacgcggttggtcgatgctgtgcgaagacccggtgtccatgctagcc ctgcacatcccggaggaggatcgctgcatcgacatcctggagctgatcgagatcgatcgt ctgttgcagttccacgcgcacacactcaccctctactcggccctttgttatcagtccaac tatcgggcagcgcatgccctgtgctcgcacgtcgaccagaagcaactactgtacgccatt cagtcggagtacatgagcggtccgctgcgactcggtttctacgatctgttgatttctctc catctcgaatcccacgccacgacaatggaggtttgtaagaatgagtacatcattccgctc gggtccgatttgcgcgagctgtacaccgatccggagatgtgtcactcgctgcgctcactg cagacgctctccgtgcgcccggaaatgaacatgaccgagattgctgaacccataccggca attgactcgttatattcgccaagattcccactggaggtggtgagagagttcgtgatgagc gccctccaggaggcggtgctcatcaatcaggtacacaatcgcgatccgatcggtggatca aacgagaacctcttcctgccactgatcaagctgatcgatcgtttgctgctggttggcgtt atcaccaacgaggacgtcgagaagctgctgatcatgatcgatccggaaacttgggaccca ttgttcgagaaggagggtaaagacgaacaccgcaagggactgctgacgatgaagatggcg gagggtgcaaagttgcaaatgtgctatctgctacaccatctgtacgacgtacagctgcgc catcgtgtggagagtataatctcattcgcacacaactatgttggtgatctgcagcaggat cagctacgcagatacattgagatcaagcagtcggatttgccaagcgcagttgcggcgaag aaaacgcgcgagttccgctgtccgccgcgtgagcagatgaacgccatcctaggcttcaag aacctcgaagaggaggatctagagaatgcgtcctgcggctcggatctgcgcaatcggttg atcgagtttcacgagaggctcatgggcaaggtgtcgttgaatgccctgcaggaaccggaa gagccggaagccgacaaggccgaagatggacgcccgggagcgctcaagaaggtgtacaac ttcataaacgccgttaaggagctggaggaagacccgaaggaaccggtggaggaggaaaag aaaacgcctgaagaggtgttccgcaaggtgctgatcaagcagatcgtgtcctgggcggag gagtcgcagatcgagaacccgaagttggtccgtgagatgttcagtctgctcgtgcgtcag tacgacacgatcggagagcttatcaaggcgctcaacaaaacttacgtaatcaacgccaaa acgaagagcgatgtggccaacatgtgggttggactgagccagatacgtgccctgctgccg gtacagatgagccaggaggaggaagagttgatgcgaaagcgactctggaagctggtgaac aaccatacgttcttccagcacccggatctgattcgtatcctgcgtgtgcacgagaacgtc atggcggtcatgatgaatacgcttgggcggcgtgcgcaggcacagagcgacgcaccggtg cagacagccgagggcgaagagtcggcaccgaaggagaaagacacatcccaccagatggtg gtagcatgctgtaggttcctatgttacttctgccgtactggccgccagaaccagaaggct atgttcgaccactttgacttcctgctcgaaaactccaacatccttctttcacgcccgagc ctgcggggctcgaccccgctggacgtggcgtactccagcttgatggagaacaccgagcta gcactagcgctgcgcgaacactatctggagaagattgccatctacctgtcgcggtgcggt ctgcagagtaactcggaactggtcgaacggggctaccccgatctgggctgggatccggtc gagggtgaacgctacctggacttccttcgtttctgcgtctgggtgaacggggagagtgtg gaggagaatgccaacctcgtcatccgactgcttatccgccgcccggagtgtctcggaccg gcgctacgtggtgagggtgaaggcctgctgaaggccatcatggaagcgaacaaaatgtcc gaacgaatctccgaacgacgcaagatgatggacgagaccgagggcaccattgccgggctt aacttcacccaccccctgccggagggtgatgacgatgaggactacatcgacaccggtgca gccatcctgtgcttctactgtacgctagttgatctgttgggtcgctgtgcgccagatgcg gccgttatcgagcaaggcaagaacgagtcgctgcgtgcgcgtgccattttgagatcattg gttccgctggaggatctgcagggtgtgctgagtctgaagtttaccctcaccaacccggcc attggtgaggataggccaaagtccgacatgccgtccggtttggtgcctggccacaagcag agcatcgtcctgttcctcgagcgcgtgtatggtatcgaaacgcaggagctattctaccgt ctgctggaggacgctttcctgccagatttgcgtgctgcaaccatgcttgaccgcagtgac ggttccgagagtgacatggcgttgtcgatgaatcgttacatcggtaactctatccttccg ctgctgatcaagcacagtaagttctacaatgaggctgaaaactacgccagcctgttggat gccacgctgcacactgtgtaccgcatgtcgaagaatcgcatgctgaccaagggccagcgt gaagctgtatcagatttccttgtcgcactaacatccgccatgcacccggccatgttgttg aagctgctgcgtaaactgaccatcgatgtgtcgaagctgtcagagtataccactgtcgca ctgcggctactgacgctgcactacgagcgttgcgctaagtactacggcactaccggtggt ggccaggcgtcccagtttggcgcgtcctccgacgaggagaagcgtctcacgatgctgctg ttctcgaacattttcgactcgctcagcaacatggactacgatccggaactgttcggtaag gcacttccatgtcttattgcgatcggttgtgccctgccgccagactatagtctgtccaag aactcagacgacgacctgtacggtaaaccgaccggcggtggccccgatcagccgcactat aatccgcagccgatcgacacgaccgccgttcagttgaccaacgatctcaatcagatcgtg cagaagttcagcgaacactaccacgacgcctgggctagccgcaagctggagaatggatgg acctacggtgaccagtggtccgattccagcaagactcatcctcgcctgaagccgtacaac actctcagtgaaaacgaacgtgaacgctaccgtgaaccagttcgtgagagcttgaaggct cttcttgctctgaactggagaattgaacactccgaaggtgacgtcccgctatccaaccgt ggatcgatgcgtcgccagtcgaagccgaatcttggcgacacgggttcaccgttcaactac aacccgcacccagtcgacatgaccaacctgacgctgagcagagaaatgcagaacatggcc gaacggttggccgagaactcgcacgatatctgggcgaagaaaaagaacgaggagttgaac cagtgcggtggggccatccacgcacagctcgtcccgtacgatctgctgaccgacaaggag aagcgtaaggatcgcgaacgttcgcaagagttccttaagtatctgcagtaccagggtctt aagctgcacaaaccatctcgtggacaaacggaagagccgggcatgagtacggcggccatt gagcttcgtttcgcctattcgttgcttgagaagctgatctcgtacagcgatcgtgccacg atcaatatgaagttgctgaaaccatcgaccacgttcagccgtcgatcgtcgtttaagacc tgctcgcgagacattaagttcttctcgaaggtcgtcttgccgctgatggagaagtacttc tcgtcaaaccgcaactactttatcgcgatcgcaaccgcaaccaacaacgtcggtgcggct tcgttgaaggagaaggaaatggttgctagtttgttctgcaaactggccagtctgcttcgc caccggctgacggcatttggggcggatgtgcgcattaccgtacggtgcctgcaggtgctg gtgaagagcattgacgctaaatcgctggtcaagaactgtcccgagttcatccgaacgtcg atgctgaccttcttcaacaacacggctgatgatctaggccaaacgatcgtcaacctgacg gatggcaagtacgatcgactgcgcggaacgcatctgaagacatcaacctcgctagcttac gtcaaccaggtgattttgcccgtgctgacgtcgctattcgatcatttggccgcgtgcgac tatggaagcgacttgctgttggacgaaattcaggttgcgtcgtacaagatcctttcggct ttgtacactcttggcaccgatatgtcgctgactcgcgaccgtaaatacctgaagacggaa ctggagcgccacaagccggccctcggatcctgtctcggtgcattcagctcctgtttcccg gtggcattcctcgagccgcacgccaacaagcacaatccgttctcgctactgaaccgcatc gccgacacgtccctcgaggcgcaggacatcatgaccaagatggaaagcagcatgccgacg ctcgagtcgattctggccgaggtggaccagttcgtcgagtcggagaagacgtaccaggag gcgcagcacattatcgatgtaattctgccgctgctgtgttcgtacctaccgttttggtgg aaccagggcccggacaatgttagcccgcagaccggcaatcacgtcacgatggtaaccgct gaacacatgaaccacctgctgaagaatgtgctcaagatgatccgcaagaacattgctaac gagaacgcaccgtggatgacgcgcattgccacctacacgcagcagatcatcatcaacagc tccgaggagctgctcaaggacgtctttctgccgttggccgagcgggtcaagaagcgttgc gacagtatgttccacaaggaggaaagcttgcgtggtttcctcaagtcttccaccgatgat acctcccagattgaagcacaaatccaggaggactggcaactgctggtccgcgatatctac tcgttctatccgctgctgatcaagtacgtcgacctgcagcgcaaccactggctcaaggat aacgtgtccgaggcggaagagctgtacaactacgtggcggagatcttcaacgtgtggtcc aagagccagtacttcctgaaggaagagcagaacttcatctcggccaacgaaatcgacaac atggcactgatcatgcctactgccacccgtcgctcggcagccatttctggtgacgttccc gcctccggtggcaaggtgaagaagaagaagcgtagccgcgacaagaagcgtgacaaggac aaggaaattcagtccagcttgatggtcgcctgtttgaagcgtctgctgcccgttggcctg aatttatttgccggcaaggagcaggaactggttcaacactgcaaggatcgctatttgaag aaaatgcccgaatacgaggtgatcgagtttgctcgcacgcaattgacactgccggacaag ctcgaccctgccgacgaaatgtcctggcagcattatctgtactcgaagctcggcaagaag gagcaaatagtcgcggactcgctcgaaaagtctgacaaaaagcccgaaaacaaaatcgaa gacacggtcgagcgcatcgtcgccatggccaaggttctttatggactgcacatggcatgc cgacctattgcgaaaggtcttaattggacacaagttttatcacaagcacgacgcaaaatg gctgttgcatgtctaagagcaaaaccaatgtatagattgagcagacaccgcgcgtgcaat atcttcggtcggagctactcggaactgtggctagaggatgagaatgtcgggcaagaggtc atgatagaggatcttacgcaaacatttgaagatgccgagaagaaaaagaaggacgaagaa gaagaggaaggcaagccggatccactgacgcagctggtaacgacgttctgccgcggagcg atgacagagcgtagcggtgcattgcaggaagatccgctgtacatgtcgtacgccaacatt gtggctcgatcgtgcggagaagaggaagaggaaggcggagatgaagaggaaggtgctgga gaagatgaaggcggcgctagcattcatactatgcaaaagctaatggaacaagaaatggag aagcagaaactcttgttccaccaggcccgtttggcgaaccgtggtgtggcggagatggtg ctgctgcacatttccgcctcgaagggtctgccctcggagatggtgatgcgtacgctggag ctcggtatcgccgtgctacgcggcggtaacatcgacattcagatgggcatgctgaaccat ctgaaggagaagaaggacgtcggattcttcacctcgatcgcgggcctgatgaactcgtgc agcgtgctcgatctggacgcgttcgagcgaaacaccaaggccgagggtctcggtgtcggc tcggatggtgccgccggtgagaagaacatgcatgatgccgagttcacctgcgcgctgttc cgctttattcagctgacctgcgagggtcacaacttggactggcagaattatctgcgtacg caggccggtaacacgaccaccgtcaacgtggtcatctgtacggtcgattacctgctgcgt ctgcaggagtcgattatggacttctactggcactactccagcaaggagctgatcgatccg gccggtaaggccaacttcttcaaggcaatcggtgtggccagccaggtgttcaacaccctc actgaggtgattcagggtccgtgtacgcagaatcagcaggcgctcgcgcactcgcgtctg tgggacgcggtcggtggtttcctgttcctgttctcgcacatgcaggacaaactgtcgaag cactcgagccaggtggacctgctgaaggagctgctcaacttgcagaaggacatgatcacc atgatgctgtccatgctggagggcaatgtcgtgaacggcaccatcggcaagcagatggtg gacacgctggtcgagtcggcctcgaacgtcgagctgatcctgaagtacttcgatatgttc ctgaagctaaaggacctaacgtccacgccgagcttcatggagatcgatgcgaacggcgac ggctggatcatgccgaaggatttccgcgaaaaaatggaacagcagaagagctacacgccg gaggagatcgacttcctgctggcgtgctgcgagaccaaccacgacggcaagatcgactac atcggcttcgtcgaccggttccacgagccggctaaggagatcggctttaacctggcggtg ctgctgacgaacctgtccgagcacatgccgaacgagccgcgcctggcgcgcttcctagag acggccggctcggtgctgaactacttcgaatcgttcctcggccgcatcgagatcatgggc tcgtccaagcgcatcgagcgcgtctacttcgagatcaaggaagcgaacatcgagcagtgg gagaagccgcagatcaaggagtcgaagcgtgccttcttctactcgatcgtcaccgagggt ggcgataaggagaagctggaggcgttcgtgaacttctgcgaggacgccatctttgagatg acgcacgcgtccgggttgatggcgagcgacgacgacggcgcaaccgtgcgccgcgaccaa gcctttacgtacatcagcgaggaggaagaggagcgggccgcccaggacccgatcaagcgc accatccaggcgatcaaggatggcctctcctactcgatgtacatgatcagcccgtccaac atcaagcaccagattaccgtactgcagtcgaaatcattccccgaaatcattgtcggcttc ttcaagatgatattctacgcgttctactactctggctttggcgtttcggtcgtgatccga tacctggtgaacatcctcatgtcactgatgcgcggaccagcccaggaggaggaggaaccc atcccggaggcggaaccgtccctacgggcactaccaccattgcccctcgaggaaccgcca ggtacggtgcaagcgtttggattggatatcagcaaggaggagaacggacagtaccgcatg gcaccgcacgagtcgcccgccctaagcccctcgtcgtcgatcgaggaaacgggtgagagc agtccggaggatggcgcaaacgagctgacgggcgaaggtgtcgcgccgggtgagcagatg actctggtcgatctgctcggcggtgaagcggcgaagcgtgccgcccaggagcgcaccgag gcgcagaaggcgcaggaggcaacgctggcaagcatcgaggccgaatcgaagaaggcgtcg gccgaaacgaaggaacccgccgccgtgcaccagatcgacttctccaagtacacgaaaaag tgcgtcagctacctggcgcgcaacttctacaacctcaagtacgtcgcgctggtgctggcc ttctgcatcaacttcatgctgttgttctacaaggtgacgacgctcggcgacgatgaggac gcggaagggtcgggcgagggcctgatgggacttggctccggcatgggatctggccttggc attttggaaacgggatcgggcggcggtgctgatggcggcagcggcgacggcgaaggcgaa gaggaggatccactcgagaaggtgcatgtcgatgaggacttcttctacatggaacacgtg ttgcgggtggccgccatactgcacagcttggtctcgcttgccatgctgatcgcctactac cacctgaaggtgccgctggctatcttcaagcgcgagaaggaaattgcccgccgactggag ttcgacggactgttcattgccgagcagccggaggacgacgacatcaaatcgcactgggac aagctggtcatctcggcgaagacgttcccggtgaactactgggacaagttcgtgaagaag aaggtccgccagaagtacagcgagacgtacgatttcgactcgatctcgaacctgctcggc atggagaagacggcgttcgcggcgcaggaggcgaacgagggcggcggcttcttccacttc atcgcgaacatcgactggcgctaccagatctggaaggccggtgtaacgatcacggacaac tcgttcctctactcgctctggtacttcaccttctcggtgatgggcaacttcaatcagttc ttcttcgccgcccatcttctcgatgtggccgtcggtttcaaaacgctccgcacgatcctg cagtcggtcacgcacaacggcaagcagctggtgctgacggtgatgctgctcacgatcatc gtctacatctacacggtcattgcgttcaacttcttccgcaagttctacatccaggaggac gacgatggcgaggagggcgaccggaagtgccacgacatggcaacctgcttcgtgttccac ctgtacaagggtgtgcgggcgggcggtggcatcggtgacgaaatcggtgaccccgacggc gacgagtacgaggtgtaccgcatcctgttcgacattacgttcttcttcttcgtcatcgtc atcctgctggccatcatccagggtttgatcattgatgcgttcggtgagcttcgtgatcag ctcgagtcggtcaaggaggacatggagtctaactgcttcatctgtggaataggcaaggac tacttcgataaggtaccgcacgggttcgatacgcacgtggcacaggagcacaacctggcc aactacatgttcttcctgatgcatttaatcaacaaaccggataccgagtacaccggtcaa gagacgtacgtgtggaacatgtaccagcagcgctgctgggacttcttccccgtcggtgac tgcttcagaaagcagtacgaggatgagctgggcggtggaggcagctaa

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