Aptenodytes forsteri (emperor penguin): 103902594 Help Entry 103902594         CDS       T08527                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism afor  Aptenodytes forsteri (emperor penguin) Pathway afor04020   Calcium signaling pathway afor04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:afor00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     103902594 (RYR3)    04020 Calcium signaling pathway     103902594 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:afor04040]     103902594 (RYR3) Ion channels [BR:afor04040]  Voltage-gated cation channels   Ryanodine receptor    103902594 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR Ins145_P3_rec SPRY RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 TBK1_ULD Motif Other DBs NCBI-GeneID:  103902594 NCBI-ProteinID:  XP_009281936 LinkDB All DBs Position Unknown AA seq 4865 aa AA seqDB search MAEGGEGGEDEIQFLRTDDEVVLQCVASIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCICNFVLEQSLSVRALQEMLANTGDNASEGAAQGGGHRTLLYGHAILLRHSFSEMYL TCLTSSRSQTDKLAFDVGLRENAAGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSMSNGSIQVDASFMQTLWNVHPTCSGSNITEGYLLGGHVVRFFHGHDECLTIPSTD HNDSQHKKVLYETGGAGVRARSLWRVEPLRISWSGSNVRWGQPFRLRHITTGKYLALNED EGLAMLEREKSDTTSTAFCFRASKELKEKQDSSLKRDIDGMGVPEIKYGDSVCFVQHVAS ALWLTYKAQDAKSARLGPLKRKVILHQEGHMDDGLTLQRCQHEESQAARIIRNTTSLFSQ FVSGNNRTLSPTALPIEEMAQTLQDLITYFQLPEEDLEHEDKQSKLRSLKNRQNLFKEEG MLALVLNCIDRLNDYNSAAHFAGFAREEHGTAWKEILNLLYKLLAALIRGNRNNCTQFSS NLDWLISKLDRLESSSGILEVLHCILIESPEALNIIAEEHIKSIISLLDKHGRNYKVLDV LCSLCVCNGVAVRANQNLICDNLLPRRDLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRVPRAVASVNQHLLSSDDVVSCCLDLGVPSISFRINGQPVQGMFENFSTEGFFFPVVS LSAGVKVRFLLGGRHGEFKFLPPAGYAPCYEALLPKEKMKLEPVKEYKRDSNGVRDLLGT TQFLSQASFIPCPIDTSQIALPFHLEKIRDKLAENIHELWGMNKIELGWTYGKIRDDNKR HHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIVHAHPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSEVKLLPSQEFLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRESLREAVRTFAGYGYSIEPPDQEIADQTMEKVSIDKIRFFRVEQSY AVKSGKWYFEFEAVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSKGQRWHQGSGFFGR SWQPGDVVGCMINLDDKSIIFTLNGELLITSKGSELAFADFGIESGFVPICALGLSQIGR MNLGMDASTFKYYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKNHPHIEIWRID GTIESPPRLKVTHKTFGTQNSNSDMIYCRLSMPIEFRSSFNFGMGVENASSDVFQKRKHS QEIAAPSTTCFYLLRIFAGQDPSSVWVGWVTPDYHFYSENFDLNKSCTVTVTLGDERGRV HESVKRSNCYMVWGGDVIANSQRSGRSNVDLEIGCFVDLATGMLSFTANGKELGTCYQVE PNTKLFPATFVQPTSTNLVQFELGKLKNTMPLSAAIFKSEERNPVPQCPPRLDVQTITPV LWSRMPNTFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMKFH YHTLKLYSSVSALGNTRVAYALCSHVDISQLFYTIDNQYLPGLLRSGFYDLLISIHLEHA KQAKLMMNNEFIIPVTDETRTIKLYPDEKKKHGLPGVGLSTCLKPGFNFSTPCFIVTSEE RQTSSPEIPLDILKSKAISMLTEAVQCSGSHIRDPVGGQVAFQFVPVLKLIATLLIMGVF DDDDVKQVLLLVDPNVFGDHKEETEERTEKEEVTQVEEKAVEAGEKAIKETKAPAKGLLQ TRLPESVKLQMCHLLNYFCDCELQHRVEAIVSFADHYVSKLQYNQKYRYNELMQALNMSA ALTAKKTKEFRSPPQEQINMLLNFQLGEDCPCPEEIRDELYEFHDDLLTHCGIPLEEEEE EEEDSSLTGKLRSLMYKIKGPPKAEKVEPKEEEEKSPTTLKELISQTMVRWSQEDQIQDP ELVRIMYTLLRRQYDSIGELLQALRKAYTISAVSVKDTINLLAALGQIRSLLSVRMGKEE ELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMDVMVNVLGGDKSQQIVFPQMVASCCR FLCYFCRISRQNQKAMFEHLSYLLENSSVGLAFPSMRGSTPLDVAAASVMDNNELALALE EPDLDKVVTYLAGCGLQSCPVLLAKGYPDIGWNPIEGERYLSFLRFAVFVNSESVEENAS VVVKLLIRRPECFGPDLRGEGGNGLLAAMQEAIRISENPTRDLPSQAYKREGDDDAEEDI VHMGNAIMSFYSALIDLLGRCAPEMHLIQSGKGEAIRIRSILRSLVPTEDLVGIISIPLK LSTVNKDGTVNEPDMSANFCPDHKAPMVLFLDRVYGIKDQSFLLHLLEVGFLPDLRASAS LDTVSLSTTEAALALNRYICLAVFPLLKRCAPLFSGTEHHASLVDSMLHTIYRLSKGRSL TKAQRDTIEECLLAICHHLRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTNHYEQCWKYY CLPSGMGSYGIAAEEELHLTEKLFWGIFDSLSHKKYDPELFRMALPCLSAIAGALPPDYL DTRIRSTLEKQTSVDPEGNFDPKPVSTANLVLPEKLEYIVSKYAEHSHDKWAFDKTNSGW KYGVSLDENMKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAMGWSLERTKEGGEAIIH QRENEKLRSISQSSQGNGYSPAPLDLSNVVLSRELQGMVEVMAENYHNIWAKKKKMELES KGGGSHPLLVPYDTLTAKEKSRDREKAQELFKFLQVNGIIISWGLNDMELDASSMEKRFA FKFLKKILKYVDSAQEFIAHLEAIVTSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHCLY FMSSPTKTLSSSGYASNKEKEMVASLFCKLAALVRHRISLFGSDSATMVNCLHILAQSLD TRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVAL LPILTSIFEHISQYQFGIDLLLGDVQVSCYRILCSLYSLGTGKNIYVERQRPALGECLAS LAAAIPVAFLEPSLNHYNPLSVFNTKSARERAILGMPDTVEEMCPEIPQLDGLIKEINDL AESGARYTEMPHVIEVILPMLCNYLSYWWERGSESVPQSAGPCCTMITSEHLSIILGNIL KIINNNLGIDEASWMKRIAVYAQPIISKARPDLLKTHFIPTLEKLKKKAIKIVMEEEQLR ADSKTDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRANWLKKPDADSDELFRMVAE VFILWCKSHNFKREEQNFVIQNEINNLAFLTGDTKSKMSKSGGQDQERKKSKRRGDLYSI QTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRYSHRDTDDEVKEHLRNNLHLQEKSDD PAVKWQLNLYKDILKSDEPTDPERNVERVQRISAALYHLEQVEQPLRSKKAVWHKLLSKQ RKRAVVACFRMAPLYNLPRHKISNFFLSTFQRVWLEKVHEKTQYDRLILKLTTPPKKDEE EEEETEKKQPDPLHQIILYFSRSALTERSKLEDDPLYIAYSAMMAKSCQEEDEEEEEKEK TFEEKEMEKQRTLYQQARLHDRGAAEMVLQMISASKGHTGPMVVETLKLGIAILNGGNTI VQQKMLHYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERG EKVLQHDEFTRDLFRFLQLLCEGHNNDFQNYLRTQMGNTTTVNIIISTVDYLLRLQESIS DFYWYYSGKDLIDESGQRNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVG FLHVFANMQMKLSQDSGQIELLKELLDLLKDMVVMLLSLLEGNVVNGTIGKQMVDTLVES SSNVEMILKFFDMFLKLKDLTNSDAFKEHDPDGKGIISKKEFQKSMEAQKQYIQSEIEFL LSCAEADENDMFNYVDFVERFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQSLLEPAESVL NYFEPYLGRIEIMGGAKKIERVYFEISESSRMQWEKPQVKESKRQFIFDVVNEGGEQEKM ELFVNFCEDTIFEMQLASQISETDSSERPEEEEEAEPCYVVDIGDDEEEEKSLESASAFA MACVAVKKNVANFFKMVTVKNLRKQYRKVRKMTVKEMVKVFFSFFWILFVGMFQLFFTIV WGIFQILWSTVFGGGLVEGAKNIKVTKILGDMPDPTQFGIHDDVMEAEKAEGTEHDIRAE LVQFVKGEKGETDMISDIFGIHTKKEGGLKHGHDAGLGDIAEIHGTDTQSSLENTVCKRK GLKISEIAKEAETERKAEAEKADMEDGEKQDQAKEVQSEQLEEGKMKKKKRRHVQKIEKP EAVMANFFKALEIYQTKMLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLDEVEED SNLWNSFDDEEEEEGMVFFVLEESTGYMAPALRALAVIHTIISFVCVIGYYCLKVPLVVF KREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDL YGAERIAELLGLDKSALDFSPVEESEPEEASLVSWLSSIDTKYHIWKLGVVFTDNSFLYL AWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLILTVGLLAVVVYLYT VVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMY RIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTP HGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESFVWKMYQERCWDFFPAGDCFRKQY EDQLG NT seq 14598 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggtgaaggaggggaagatgaaatacagttcctacgaactgatgacgaa gtagtacttcagtgtgttgccagtattcacaaagaacaaaggaagttttgcttggcagct gagggacttgggaatcgcctgtgctttttggaaccaacatcagaagctaaatatgttcct ccagacctttgcatctgtaatttcgtccttgaacagtccctatccgtcagagcccttcaa gaaatgctggccaacacaggggataatgctagtgaaggggcagctcaagggggtggtcac agaaccctgctgtatggccatgctatactacttcgacattcatttagtgaaatgtatttg acatgtttaacatcatcaagatcccagacagataaacttgcatttgatgtgggactacga gaaaatgcagcaggtgaggcatgctggtggacaatacaccctgcttctaaacaaaggtca gaaggagagaaagttcgaataggtgatgatcttatcctggtcagtgtgtcctctgaaaga tacctgcatctttccatgtcaaatggaagtattcaggtggatgcctcctttatgcagaca ctatggaatgtacatcctacatgctcaggaagcaatattacagaaggatatctgcttggt gggcatgtagtacgttttttccatggccatgatgagtgtttgacaattccatctacagat cacaatgattcacagcacaagaaagtactttatgaaaccggaggagctggtgttcgagca aggtctttgtggagagtagagccccttcgaataagctggagtggaagtaatgtcagatgg ggacagcctttccgtcttcgacatattacaacaggaaagtacttggctctgaatgaagat gaaggacttgcaatgttagagagagagaagtcagacacaacatctactgccttttgtttt agagcatcaaaggagctaaaagaaaagcaggattccagtcttaaacgtgacattgatgga atgggagtcccagaaataaagtacggtgattcagtctgttttgtccaacacgtggccagt gccttatggttgacttacaaagcacaagacgctaaatcagcacgtttaggtcccttgaaa agaaaggttatattgcaccaagaaggccatatggatgatggtctaaccttacaaagatgt cagcacgaggaatcccaggctgctcgaatcattcgcaatactacaagcttattcagccag tttgtaagtggaaacaacagaacactatcacccactgccctgcctattgaggagatggct cagactctgcaagacctgattacttacttccagcttcccgaagaagacctggaacatgaa gataagcaaagcaagcttcggtcactcaaaaacagacaaaatctattcaaagaagaggga atgctggcactagttttgaattgcattgatcgcttaaatgactacaacagcgcagctcat tttgcaggatttgcaagagaagaacatggtacagcatggaaagaaattttgaacctcctt tacaaattgttagctgctctcattcgtggcaacagaaacaattgtactcagttttccagt aacctcgattggctaataagtaaattggacagattagaatcttcctcaggtattttggaa gtgttgcactgcatcttgattgaaagcccagaagctttaaatataatagctgaggagcac atcaaatccattatttcattgttggataaacacgggcgcaattacaaggttctcgatgtg ctttgctctctctgtgtctgtaatggagttgcagttcgtgccaatcaaaatttgatctgt gacaatctactgcctagaagagacttactcttgcaaacacgtttgattaatgatgtgaca agcataaggccaaacatatttttgggtgttgctgagggctctgcacaatacaagaagtgg tactttgagttaataattgatcaggttgatccattcttgacggcagaacccacccattta cgagttggatgggcctctacttcaggttatgccccctatcctggaggtggagaaggatgg ggaggcaatggtgttggtgatgacctatactcctatggttttgatggccttcatctgtgg tctggtcgagtacccagagctgtagcatctgtcaatcagcatttattatcatctgatgat gtggttagctgctgcttggatttaggtgtacctagcatttcattccgcattaatggacag cctgtacaaggaatgtttgagaacttcagtacagaagggtttttcttccctgttgtaagc ttatcagcaggtgtaaaagttcgcttcttattgggtggacgtcatggagagtttaaattt ttgcctcctgctggctatgctccttgttatgaagcgttgcttccaaaagagaagatgaaa ctggaaccagtgaaagaatataaaagagattctaatggagtgagggatttgctgggtaca acacaattcctctcccaagcttcctttatcccttgtccaatagacaccagtcagattgct cttccttttcatcttgaaaagatcagggataaactagctgaaaatatccatgaactgtgg ggaatgaataaaatagaacttggctggacatatggcaagatacgggatgataataaaaga catcatccttgtcttgtggaattctcaaaattacctgagacagagaagaattataatcta caaatgtcaactgaaaccctcaaaacccttttggcccttggatgtcacattgttcatgct catccagcagctgaggaagatcttaaaaaagtcaaactccctaaaaattacatgatgtca aatggatataaacctgcccctcttgatctttctgaagtgaaattgttaccttctcaagaa tttctagttgacaaactagcagaaaatgcacataatgtctgggcaaaagacagaataaag caaggatggacctatggcattcagcaggatcttaagaacaaacgtaatcctcggctagtg ccatatgcattattagatgaacgtactaaaaaatcaaacagagagagcctccgcgaagct gttagaacatttgcgggctatggttatagtattgagccacctgaccaagagatagctgac caaacaatggaaaaagtcagcatcgacaagatacgatttttcagagtagaacagtcttat gcagtgaagtctggaaagtggtactttgaatttgaagctgtgacaggtggagatatgcgt gttggctgggccaggccaggctgtcgacctgacatagagttgggagctgatgaccaagca tttgtatttgaaggaagcaaaggccagcgttggcatcaaggtagtggattctttggacga agctggcaaccaggagacgtggttggttgtatgataaacttggatgataaatcaattatc tttacactgaatggagagttgcttataaccagtaaaggttcagaacttgcgtttgctgac tttggaatagaaagtggttttgttccaatttgtgcactgggtctatctcagattggtcgt atgaaccttggaatggatgccagtacattcaagtattatacaatgtgtggccttcaagaa ggttttgaaccttttgctgtcaacatgaaccgagatgttgctatgtggtttagtaaacgc ttaccaacatttgtcaatgtgccaaaaaatcatcctcacattgagatatggagaattgat ggaaccattgagagtccacctcggttaaaagttactcacaaaacatttggcacacagaac agcaattcagacatgatatactgtcgtttgagtatgcccattgagttccgctcatcattc aacttcggcatgggtgtggaaaatgcctcatctgatgttttccaaaaacgaaagcacagc caagaaattgctgctccttctactacatgtttttatttactacggatatttgctggccaa gacccatcctctgtctgggttggctgggtaacaccagattatcatttttacagtgagaat tttgacctaaataaaagttgtacagtgacagttactttaggtgatgagagaggcagggtt catgaaagtgtgaagcgcagcaactgctatatggtttggggaggagatgtaattgctaat tcccagagatcaggtcgcagtaatgttgatttagaaattggatgctttgttgacctggct actggaatgttgtcattcacagccaatggaaaagagcttggcacttgttatcaggttgaa ccaaacacaaagctttttccagcaacttttgtacagcctacgagcactaacttggttcag tttgaacttggtaaattaaagaataccatgcctttatcagctgcaatttttaaaagtgaa gaaagaaatcctgttcctcagtgtccccctcgccttgatgtgcaaacaattacacctgtt ctatggagcaggatgccaaacacctttctaaaagtagaaactgagcgtgtcagtgaacgt catggctgggttgtgcagtgtttggaacctctgcagatgatggcacttcatatcccagaa gaaaacagatgcgttgatattttggaactatgtgaacaagaagatttgatgaagtttcac taccatactttaaaactctatagctcagttagtgctctaggtaacactagagttgcttat gcactttgtagccatgtggacatatctcagctattttataccatagataatcaatactta cctggactcctacgttctggattctatgacttgctcattagtattcatttggagcatgcc aagcaagccaagctcatgatgaacaatgaatttatcattccagttacagacgaaactcga actattaaattatatcctgatgaaaaaaagaagcatggtttacctggagtaggacttagc acttgtctgaaaccaggctttaatttttctactccatgctttattgtgaccagtgaagaa cgtcagacatccagcccagagataccccttgatatacttaaatccaaggccataagtatg ctaacagaggcagtacagtgtagtggtagtcatatacgagaccctgttggaggacaggtt gcattccagtttgttcctgttcttaaactgatagcaacattgctcataatgggggttttt gatgatgatgatgtgaagcaggtgttactcctcgttgatcccaatgtgtttggagatcac aaggaagaaacagaagagaggacagagaaggaagaagttacacaagttgaagaaaaagct gtagaagctggggagaaagcaataaaagaaacgaaggctcctgcaaagggcttattgcag acaagattaccagaatctgttaagcttcagatgtgtcatttactcaattatttctgtgac tgtgagctacaacatagagtggaagcaattgtatcatttgcagaccattatgtatcaaaa ttgcaatataatcagaaatacaggtacaatgaactcatgcaagccttgaacatgtctgct gctttgactgccaagaagactaaagaatttcggtctcctcctcaagaacagattaatatg ttgctgaattttcaactgggagaggattgtccctgtccagaggagattcgagatgagtta tatgaatttcatgatgatcttctaactcactgtggtattccactagaagaggaagaagag gaagaggaagattcctccttgactggcaaactccgttcattaatgtacaaaatcaaaggt ccaccaaaagcagaaaaagtagaacctaaggaggaagaagagaaatctcctactacactg aaagaactcatatcccagactatggtgcgctggtcccaggaagatcagattcaagatcca gaattagttcggattatgtacacgctccttcgtaggcaatatgacagcattggtgagcta ctgcaagctctgaggaaagcatacactattagtgctgtctctgtgaaggataccattaat ctgctcgcagcgctgggccagattcgctcacttctcagtgtcaggatgggaaaagaggag gaattgctaatgattaatggattaggggatataatgaacaacaaggtgttttaccagcat cctaacttaatgagggtcttgggcatgcatgagactgttatggatgtgatggtgaatgtg cttggaggagataaatctcagcagatcgtttttcctcagatggtggcaagttgttgtcga ttcctgtgctacttctgtcgaattagtcgtcaaaaccaaaaggccatgtttgagcatctt agttacttactggaaaacagcagcgttggactggcgtttccttcaatgagaggttcaaca ccactagatgttgcagcagcctctgtaatggacaacaatgagcttgcactagcattggag gagccagatctcgataaggttgttacctacctggcgggttgtggcctgcagagttgtcca gtattgctggctaaaggatatccagacattggatggaatccaatagagggtgaacgttac ctgtcattcttaagatttgcagtttttgttaacagtgaaagtgttgaggaaaatgcaagt gttgttgtcaagctccttattcgacggccagagtgcttcggaccagacctaaggggagaa ggaggaaatggtttgctggcagctatgcaggaagctatcaggatctcagagaatcctaca cgtgaccttccctcccaggcatataaaagagaaggtgatgatgatgctgaggaggacatt gtgcacatgggcaatgcaatcatgtcattttactcagctctcatagatttacttggacgc tgtgcaccagaaatgcatcttattcaaagtggaaaaggggaagctattcgaatcaggtca atccttcgatctctagtgccaactgaagatttggttgggattataagtataccactaaag ctgtcaacagttaacaaagatggcacagtaaatgagccagacatgtctgcaaatttctgt cctgatcataaagcacccatggtactcttcttggaccgtgtctatggtattaaggaccaa agcttcctccttcacctactggaagttggatttttaccagatttaagagcctctgcctct ttggatacagtttctctaagtaccacagaggcagcactcgcactaaatagatatatttgc ttagctgtgtttccattactcaaaagatgtgctcccctcttttctggaacagagcatcac gcctctctggttgactccatgcttcacacaatatataggttatccaagggacgttccctt acaaaagcacaaagagacactattgaagaatgcctgcttgctatttgccaccacttacgt ccctctatgctgcaacagctgttgagaaggctagtttttgatgtgccgctactcaatgaa tactgtaaaatgcctctcaagcttctgacaaatcactatgaacagtgctggaaatattat tgtctgccttcaggaatgggaagctatggaattgcagcagaagaagaattacatttaact gaaaaacttttctggggaatatttgattccttgtctcataagaagtatgatccagagctc tttcgaatggctttgccttgtctaagtgctatagctggtgccttgccccctgattattta gatacacgaattaggtcaactttggaaaagcagacttcagtggatccagaaggaaatttt gatcccaaacctgtcagcacagcaaaccttgtacttcctgaaaagttggaatatattgtc agcaagtatgctgaacattcccatgataaatgggcctttgataagactaatagcggatgg aaatatggtgtttcactggatgaaaatatgaagactcacccgttaataagacctttcaaa actttaactgagaaggaaaaggaaatttatcgttggcctgccagagaatcactgaaaacc atgctggccatgggatggagcctagaaaggaccaaggaaggaggagaggcaataatacat cagcgtgaaaatgaaaagctccgcagcatatctcagtctagccagggaaatgggtatagc ccggcaccacttgatctctctaatgtggtgctttctagggagcttcagggaatggttgag gtaatggcagaaaactaccataatatatgggccaaaaagaagaaaatggagttggaaagc aaaggtggaggtagtcatcctttattggtaccttacgacacattgacagccaaggagaaa tcaagggaccgtgaaaaggcacaagagctgtttaaattccttcaagtcaatggtataatc atatcttggggtctgaatgacatggagttggatgcttcatccatggaaaagaggtttgcc tttaagtttctgaagaaaattttaaaatatgttgattctgctcaagagtttattgcgcat ttggaagccattgtaaccagtggaaaaactgaaaaatctccacatgaccaagaaataaaa ttctttgccaaagttcttttaccattagttgatcagtactttacaaatcactgcctctac ttcatgtcttctccaacaaaaacactcagtagcagtggatatgcatcaaataaggaaaag gaaatggtagcaagcctgttctgcaaactagctgctcttgttagacataggatctcactt tttggtagtgattctgctacaatggtgaactgcctgcacatcttagctcagtctcttgac acacgaactgttatgaaatcaggatctgagcttgttaaagctggattgcgtgcctttttt gaaaatgcagctgaagacctggaaaagacttcagaaaatcttaaacttggaaaatttacc cattcaagaacacaaatcaagggtgtttcacagaatatcaattatactacggtagcattg ttaccaatcttgacatcaatttttgaacatatttcacaatatcagtttggaattgattta cttctgggtgatgtacaagtttcatgttacagaattctttgtagcctctattcccttggg actgggaagaacatctatgttgaaaggcagcgtcccgcgcttggtgagtgcttagcatct cttgcagcagccattccagtagcattccttgaaccttctcttaatcattacaacccattg tctgtcttcaacacaaaaagtgcaagagaaagagcaattttaggtatgcctgatacagta gaagagatgtgtccagagatccctcagttggatggactaataaaggaaattaatgattta gcagagtctggagcaaggtatactgaaatgcctcatgtaattgaggttatcttacccatg ctatgcaactacttatcctactggtgggaaagagggtctgagagtgttcctcaaagtgct gggccttgctgtacaatgataacatctgagcatctgagcattattcttggaaacattctg aaaatcattaacaacaatctgggaatagatgaagcatcttggatgaaaagaattgcagtt tatgctcaacccatcatcagcaaagccaggcctgatctgctcaaaactcactttattcca acactggagaaattgaagaagaaagctataaagatcgtgatggaagaggagcaactgaga gcagatagtaaaactgacacccaagaagctgagctactcattctcgatgagtttgctgtt ctttgtagagacctttacgccttctatccaatgttgatacgttatgtagacaacaacaga gccaattggctaaagaaaccagatgcagattctgatgaactctttcgaatggtagctgaa gtttttatcctgtggtgtaaatcacataatttcaaaagagaagaacaaaattttgtgatt cagaatgaaatcaacaatttggcatttttaacaggagacaccaagagcaagatgtctaaa tctggaggacaagatcaggagagaaagaaatcaaaacgtagaggggatttgtactccata caaacatccttgattgtagctgcacttaaaaagatgcttcctattggtttgaatatgtgt actcctggagatcaagagctcatctctttggctaagactagatacagccatagggacact gatgatgaagtcaaagaacatttacgtaacaacttgcatttgcaggaaaagtctgatgat ccagctgtgaaatggcagttaaatctgtacaaagacattttgaaaagtgatgaacccact gaccctgagagaaatgtggaacgtgtgcagaggatatcagctgctctgtatcatctggaa caggttgaacaaccactgagatcaaagaaagctgtttggcacaaactcctgtcaaaacaa cgcaaacgggctgttgttgcatgtttcagaatggcaccattatacaacctgccaagacac aaaattagcaatttcttcctgagcacctttcaacgtgtttggctggaaaaagtacatgaa aaaactcagtatgacaggcttatactcaagttaacgacacctccaaaaaaagatgaagag gaagaggaagagaccgagaaaaaacagcctgatccacttcatcagattatcctctatttt agtcgcagtgctctcacagagagaagcaaactagaagatgatcctttatatattgcctat tccgccatgatggcaaagagctgtcaggaagaagacgaggaagaagaagaaaaagaaaag acatttgaggagaaagaaatggaaaaacagagaactctctatcagcaagctcgcttacat gatcgtggagctgctgagatggtccttcagatgattagtgcaagcaaaggtcatacagga cccatggttgttgaaacactaaaacttggtattgctattctaaatggtgggaataccata gttcaacagaaaatgctacactacctgaaggagaaaaaggatgctggattttttcaaagt ctctctgggttgatgcagtcctgcagtgttcttgacttgaatgcgtttgagagacaaaat aaagcagaaggcctgggaatggttactgaagaaggaactcttatcgttcgtgagcgtggt gaaaaagtgttgcagcatgatgaatttactcgagatctatttagatttttacaactgctc tgtgaagggcataacaatgattttcaaaattacctacgtactcagatgggcaacaccaca acagtgaatattatcattagtacagttgactatctcttgcgtcttcaggaatcaatcagt gacttctattggtactattcaggaaaggatctcattgatgaatcaggacaacgtaacttc tctaaagctttggctgtcaccaaacaaatattcaattcccttacagaatatatccagggc ccttgcataggtaatcaacagagtctggctcatagtaggctgtgggatgcagttgttggc tttcttcatgtctttgccaatatgcagatgaaactttcacaggactctggtcagattgaa ttgcttaaagaactgctagatctgctaaaggatatggtagtgatgctcttgtcactgctt gaaggtaacgttgtaaatggaactattggaaaacaaatggtagacacgcttgtagaatca tctagcaatgtagaaatgattttgaagttctttgacatgttcctcaagttaaaagatctg actaactcagatgctttcaaagaacatgacccagatggtaaaggcatcatttcaaagaag gaattccagaaatcaatggaggctcaaaaacaatacatacagtcagagattgaattcctg ctgtcctgtgcagaagctgatgaaaatgatatgtttaactatgttgattttgtggaaaga ttccatgaaccagccaaagacattggatttaatgtagcagtactgctaacaaacctttca gagcacatgcctaatgattcacgtcttcagagcttacttgaacctgcggaaagtgttctt aattactttgaaccataccttggccgtattgaaataatgggtggagccaagaaaatagaa agagtttactttgaaatcagtgaatctagtagaatgcagtgggagaagccacaggtgaag gaatccaaaaggcagttcatatttgatgttgtcaatgaaggaggagagcaagaaaaaatg gaactctttgtgaatttctgtgaagatacaatctttgaaatgcagttagcatcccagatc tctgaaacggattcatccgagaggcctgaggaagaggaagaggcagagccttgttatgta gtggatattggagatgatgaggaagaagagaagtccctggaatctgcttcagcttttgca atggcctgtgttgcagtgaagaagaatgttgccaacttttttaaaatggtcactgtgaag aacctaaggaaacaatacaggaaagttagaaagatgacagtaaaagagatggtgaaagtg tttttctcctttttctggatcctttttgtaggaatgttccaactgttctttactatagtg tggggaattttccagattctttggagcactgtatttgggggtggcctggttgaaggagcc aaaaacattaaagttactaaaatattaggggacatgcctgacccaacacagtttggaatc catgatgatgttatggaagcagaaaaagctgaaggcactgagcatgacatcagagctgaa cttgtgcagtttgtgaagggtgaaaagggagaaactgacatgatctcagacatttttggc attcatacaaagaaagaaggtggcttaaaacacggtcatgatgctggacttggagatatt gcagaaatccatggtaccgatacccagtcatctttggaaaacacagtttgtaagagaaaa ggattaaagatatctgaaattgcaaaagaagctgaaacagaaagaaaagcagaagctgag aaggctgacatggaagatggtgagaaacaagatcaagcgaaggaagtacaatctgagcag ctagaagagggaaaaatgaagaaaaagaagcgaaggcatgtccaaaaaattgagaaacca gaggctgttatggctaacttcttcaaagctttggaaatttatcaaacaaaaatgcttcac tacttggcaagaaatttttataacttaaggtttcttgctctatttgttgcttttgccatc aactttattcttctattttacaaggtgacagaagagccacttgatgaagtagaggaagac tctaatctctggaactcttttgatgacgaggaagaggaggagggcatggtgttttttgtt ttagaagaaagtacaggttacatggcacctgctctcagagcattggcagttattcatact atcatctcctttgtctgtgtgattggatactattgcttaaaggtccctctggttgtattt aagagagaaaaagaggtagctagaaagctggaatttgacggactatacataactgaacag ccatctgaagatgatattaaaggacaatgggatcgcctggttataaatactccgtccttt cctaacaattactgggacaaatttgtaaaacggaaggttattaacaagtacggagactta tatggagccgagcgcatagcagaacttttgggtttggacaagagcgcccttgattttagt ccagtggaagagagcgaaccagaagaggcatctcttgtatcatggttaagctccattgat acaaagtaccacatttggaagctcggagttgttttcactgataattcgtttttatactta gcttggtacacaactatgtctatccttgggcactacaacaacttcttctttgccgctcat ctgctggatattgctatgggtttcaagacgttgagaaccattttgtcttcagtcactcac aatggcaaacagctcattcttactgtaggactcctcgctgtagtagtttatctctacact gttgtggcattcaacttcttccgcaaattctacaacaaaagtgaagacgaagatgaacca gacatgaaatgtgatgacatgatgacgtgttacttgttccacatgtatgtgggtgtaaga gctggtggtggcattggagatgaaattgaggatcctgctggagacccttatgaaatgtat cgaattgtgtttgacatcacatttttcttctttgtcattgttatcctactggccattatt caaggtctgattattgatgcttttggtgaattaagagaccagcaagaacaagtgagagaa gatatggagaccaagtgttttatttgtggaatcggcaatgactattttgacacaacccca catggctttgaaacacatactttgcaagaacacaacttggcaaactatctgttcttttta atgtatctcattaacaaggatgaaactgaacatactggccaggagtcgtttgtgtggaag atgtaccaagaaagatgttgggattttttcccagcaggggactgcttccggaaacagtat gaggatcaacttggctga

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