Aythya fuligula (tufted duck): 116487755 Help Entry 116487755         CDS       T07966                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism aful  Aythya fuligula (tufted duck) Pathway aful04020   Calcium signaling pathway aful04260   Cardiac muscle contraction aful04261   Adrenergic signaling in cardiomyocytes aful04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:aful00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     116487755 (RYR2)    04020 Calcium signaling pathway     116487755 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     116487755 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     116487755 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:aful04040]     116487755 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:aful04990]     116487755 (RYR2) Ion channels [BR:aful04040]  Voltage-gated cation channels   Ryanodine receptor    116487755 (RYR2) Domain-containing proteins not elsewhere classified [BR:aful04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    116487755 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  116487755 NCBI-ProteinID:  XP_032040803 UniProt:  A0A6J3CU09 LinkDB All DBs Position 3:25240912..25656690 Genome browser AA seq 5094 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWKFMMKSAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEVAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHI TTGKYLSLLDDKSLLLTDKEKADVKSTAFCFRSSKEKLDIGTRKEVDGMGAPEIKYGDSI CFIQHVDTGLWLTYQSADAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVKSSAVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLNVYSSAAHFADVAGREAGEAWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGISEGSAQYRKWYYELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGD DLYSYGFDGLHLWSGCVARTVNSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVEHSREY KQDRSYTRDLLGPTLSLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK VKKMKLPKNYQLLSGYKPAPMDLSFIKLTPSQEAVVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHATRLDVCNG IMEKFRIFRTEKTYAVKAGKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDDEAFVFDGF KAQRWHQGNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVGDG FLPVCSLGPSQVGRMNFGKDVSTLKFFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLP VPQNHEHIEVMRIDGTIDSCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAEVFSRTAAG GLPGTGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRAEREKDATKSELNNHKDYVQEK PSRLKQRFMLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTSFDLERVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCLIDAASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQ CLNPLQFMALHIPEENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHAMCSHV DESQLLYAIENKYMPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFP DENKKHGLPGIGLSTSLRPRMQFSSPSFVSISSECFQFSPEFPLEILKAKTIEMLTEAVQ EGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLKHILQLIEPRVFKEAMSQEDE SDFSEKELSSEELKSEGEEETRGEQVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRI EAIVAFSDDFVAKLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDD KNDCPCPEEIRDQLLDFHEDLMTHCGIELDEDGTLDGSSDLTIRGRLLYLMEKVTYLKKK QAEKPVDDDAKTSSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRAL PKTYTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLM RALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLL ENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLIS KGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNG LLAAMEEAIKISEDPTRDGPSPSNGSSKTLEMEEQEDDTIHMGNAIMTFYAALIDLLGRC APEMHLIHAGKGEAIRIRSILRSLIPLEDLVGVISIPFHMPTIAKDGTVVEPDMSAGFCP DHKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCT AVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRP SMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSR KLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSEGNFN PQPVDTSNITIPEKLEYFINKYAEHSHDKWSMEKFANGWTYGETYSESAKVQPLMKQYKL LSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDAAHGYS PRAIDMSNVTLSRDVHAMAEMMAENYHNIWAKKKKMELEAKVGGGNHPLLVPYDTLTAKE KAKDREKAQDILKFLQINGYIVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYIL EFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSSGGHASNKEK EMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKMALRAFL DNAAEDLEKTMENLKQGQFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDL ILEDVQVSCYRILASLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIY SIYNTKNARERAVLNLPTSVEEVCPNIPSLVKLMEEIVELAESGIRYTQMPHIMEVILPM LCSYMSHWWEHGPENNPDKAEMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAV FSQPIISKAKPQLLKTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTT LARDLYAFYPLLIRFVDYNRAKWLKEPNSEAEELFRMVAEVFIYWSKSHNFKREEQNFVV QNEINNMSFLISDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNIC APGDQELIALAKNRFSMKDTEDEVRDIIRSNLHLQGKYRAFYFKKLMTKLAFILTWMKLK SPKSSSSHANSHLEMSTTHALRKLPIQKSCTLIECEESSDQKTSLPVHKKSFVDYPFMMI QSNTHTKTVDVTVVKKWKIRKVEEKPANCGFLGYNKLLLSDCLEDPAIRWQMALYKDLPN RNEDSSDPEKTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPL YNLPRHRAVNLFLQGYDKSWIETEEHYFEDKLIEDLAKPGEEPTEEDENLKRVDPLHQLI LLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEKEME KQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKMLDY LKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSVITHERGEKVMQDDE FTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSG KDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHM QMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMIL KFFDMFLKLKDLTSSDAFKEYDPDGKGIISKRDFHKAMESHKHYTQSETEFLLSCAETDE NETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELSESVLNYFQPFLG RIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCE DTIFEMQLAAQISESDLNERSANKEENEKDKPEEQDPGMGFFSLVTMKLALVALKYNLMT LMKMLSMKSLKKQMKKVKKMTMKDMIMALFSSYWSILMGLLHFACSVFRGFFRIICSLLL GGSLVEGAKKIKVAELLANMPDPTQDEVRGEGEEGERKPTETALPAEDLTDLRTLSDESD LLSDIFGLDLKREGGQYKLIPHNPNAGLSDLLSTPSLAPMPEEQEKIQEQMKEDEKEEKE ETKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVQESAFWKKIIAYQQKLLN YFARNFYNMRMLALFVAFAINFILLFYKVSTSAVTEEKEVPVVSTGESMKLNSLESDSQR VIAVHYVLEESSGYMEPTLRILAILHTIISFFCIIGYYCLKVPLVIFKREKEVARKLEFD GLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMD KAALDFSDAREKKKPKKDSSLSAVLNSVDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGH YNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFY NKSEDGDMPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFF VIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEH NLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 15285 nt NT seq  +upstreamnt  +downstreamnt atggccgaggggggcgagggcgaggacgagatccagttcctgcgaactgatgatgaagtg gttctgcagtgcactgcaacagttcacaaggagcaacagaaactgtgtcttgctgcagaa ggatttggcaacaggctttgctttttggaatccacatcaaattctaagaatgtgccacct gatttgtccatctgtaccttcgtgctggagcagtctctgtcagtacgagccctccaggaa atgctggctaacacagaagaaaaggcagaagggctagttgatgtggaaaaatggaaattt atgatgaagtctgcacaaggtggtggtcatcgaacactactctacgggcatgcaatcctg ctgcgccattcctatagtggcatgtatctatgctgcctgtctacatctagatcttcaatg gataaactggcatttgatgtaggattgcaagaggatacaacaggtgaggcatgctggtgg accatccatcctgcttccaagcagcgatcagaaggagaaaaagtacgtgttggagatgat cttattttagtcagtgtctcttcagaaagatacctgcatctctcttatggcaatggtagc ttacatgttgatgcagccttccagcaaacactctggagtgtagcaccaatcagttcagga agtgaagttgcccaaggatatctgataggaggggatgttctgaggttgttgcatggtcac atggatgaatgcttgacagtcccttcaggtgaacatggagaagaacaaagaagaactgtc cattacgaaggtggtgctgtctcaattcatgcacgttctctttggcgattagagactcta agagttgcgtggagtggcagccacataagatggggacagccattcagattaaggcatata acaacaggaaaatatttaagtctcctggatgacaagagtcttcttcttacagataaagag aaagcagatgtaaaatccacggcgttctgttttcgttcttccaaggaaaagttggacata gggacaagaaaagaggtggatggaatgggagcacctgaaattaaatacggagattcaata tgcttcatacaacatgtagacactggcttgtggctcacgtaccagtccgctgatgcaaag tctgtaagaatgggttctgtgcagcgcaaggcaataatgcaccatgaaggtcacatggat gatggtttaacattgtccagatctcagcatgaagaatcccgcacagcacgtgtcattcgt agtacagtcttccttttcaacaggtttataaggggccttgatgctctcagcaagaaagtg aagtcttccgcagtagatttacctattgagtcggtcagtctgagccttcaagacttgatt ggctattttcatcctcctgatgaacatttagagcatgaagacaaacaaaacaggctccga gcactgaagaatcgccagaacctcttccaggaagagggtatgatcaaccttgttctcgaa tgtattgatcgcttgaatgtatacagcagtgctgctcattttgcagatgtagctgggagg gaagctggagaagcatggaaatctattctgaattctttgtatgaattactagcggctctg attcgagggaatcgtaaaaactgtgctcagttttctggatctcttgattggttgatcagc agattagaaagactggaagcctcttctggaattctagaggttttacactgtgtgttggtg gaaagccccgaagctctaaacataattaaagaaggacatattaaatcaatcatctgtctt ttggataaacacggaagaaaccataaggtgttggatgtcttgtgttctctctgtgtatgt catggagtagctgtgcggtctaatcaacatctaatctgtgataatctcctgcctggaaga gatctgctattacagacacgcctagtcaaccatgttagcagcatgcgacccaatatcttt ttggggattagtgaaggctctgcccagtacagaaaatggtactatgaacttatggtggac catctagagccatttgtgactgcagaatcaactcatctacgagtgggctgggcttcaaca gaaggctactcaccatatccagggggaggagcagaatggggaggaaatggtgttggtgat gacttgtattcctatggctttgatggtctacatctgtggtcaggttgtgtagcacgaacg gtaaattctcccaaccaacatctgttaagaactgatgatgttattagctgctgtttggat ctgagcgctcccagcatctcttttcggataaatggtcagccagttcaaggaatgtttgag aatttcaacatagatggcctcttcttcccagttgtgagcttctctgcaggaataaaggta cgtttcttgcttggaggtcgccatggagagttcaagttccttcctccacctggatatgcc ccttgctttgaagctgtcctaccaaaagagaaacttaaagtggagcatagccgagagtac aagcaggatcgcagctacacaagagacctactgggtcccactctttctctctcacaagca gcttttaccccagttcctgtggatactagccagattgttttgcctcctcacctggaaagg attagagaaaaattagcagagaacattcatgaactttgggttatgaataagattgaactt ggctggcagtatggaccagttagagatgacaacaaaagacagcacccatgcttagtggaa ttttcaaaattgccagagcaggagagaaattataacctgcaaatgtcacttgaaacattg aaaaccctgctggcattaggctgccatgttggaattgctgatgaacatgctgaagaaaaa gtgaaaaaaatgaaacttccaaagaactaccagttgttgagtgggtataagcctgctccc atggatctgagttttatcaaactgaccccctctcaagaagctgtggtggataaactagca gagaatgctcacaatgtgtgggcaagggaccgtatcaggcaaggctggacctatggtatc cagcaggatgtaaaaaatcgacgaaatcctcgccttgtaccttatgctcttttggatgat cggacaaagaagtcaaacaaagacagccttcgtgaagcagttcgtacccttttaggctat ggttacaacctggaagctcctgaccaagatcatgcaacaagattggatgtatgcaatggg ataatggaaaaatttaggatcttccgcacagagaagacttatgcagtgaaggctgggaag tggtacttcgagtttgaggcagttacagcaggagacatgagagttggctggacaaggccg ggttgcttgccagatcaggaacttggctcagatgatgaagcttttgtttttgatggcttt aaggcacagcggtggcatcagggtaatgagcattttggccgctcatggctagcaggagat gttgttggatgtatggttgacatgaatgaacacactatgatgttcaccttaaatggtgaa atccttctcgatgactcaggttcagaacttgcattcaaggactttgaagttggtgatgga tttctgcctgtgtgcagcctgggcccatctcaagtgggaagaatgaactttggaaaagat gtcagcactctaaaatttttcactatctgtggcttacaggaagggtacgaaccctttgct gttaatacaaacagagacatcaccatttggctgagtaaaagactccctcagtttctacca gtaccacaaaatcatgaacatattgaggtgatgagaattgatggcaccatagacagctgc ccctgcctgaaggtcacgcagaagtcctttggttcacagaacagtaaaacagacgtcatg ttttttcgattaagtatgcctattgaatgtgctgaggtgttctccagaacagctgcagga gggttaccaggcactggcctttttggcccaaagaatgatttggaggattatgatgctgat tctgattttgaggttctaatgaaaactgctcatggtcatctagtgcctgaccgggcagaa agagaaaaagatgccacaaaatcagagttaaataaccataaagattatgttcaagaaaag ccttcacgtcttaaacaaagatttatgctcaggaggacaaagccagattatagcacaagc cactctgcacggcttaccgaggatgtgctagcagatgatagggatgactatgattatttg atgcaaacttcaacgtattattattcagtgagaatatttcctggccaagaacctgctaat gtctgggtaggctggattacctctgactttcatcagtatgacacaagctttgacttggag agagtacgtacagtcacagtgacactgggagatgaaaaggggaaggttcatgagagtata aagcgcagcaactgctatatggtgtgcgcaggagagagcatgagccctggacaaggacgt aataataatggtctggagattggttgcttaattgatgctgccagtggcctgctgaccttc acagctaatggcaaggaactgggcacgtactatcaggttgaacctagtacgaagttattt cctgctgtatttgctcaagctacaagccccaatgttttccaatttgaattgggtagaata aagaatgtaatgccattgtctgctggattattcaaaagtgaacacaaaaacccagtgtct caatgtcctccacgtctccatgtccagtttctgactcatgtgctttggagcagagtgcca aaccacttcttgaaggttgatgtctctcggatcagtgaacgtcaaggctggatgatacag tgcctgaatcctttgcagttcatggcccttcacattcctgaagaaaacagaacgattgat attttagagctgacggaacaagaagaactgctgaaatttcactaccataccctccgatta tattcagctgtttgtgctttagggaacaaccgagtggcccatgctatgtgtagccatgtg gatgaatctcagctcctatatgctattgagaataaatatatgccaggattattacgtgca ggatattatgacttacttattgacatccatctcaatacttatgcaactgccaggttaatg atgaataatgaatttattgttccaatgacagatgagaccaagagtattaccttgtttcct gatgaaaacaaaaaacatggccttcctggtataggacttagcacttccttgagaccaaga atgcagttttcctcgccaagttttgtaagcattagcagtgaatgctttcagttcagtcct gaattccctcttgaaatcctaaaagccaaaacaatagagatgctaactgaagctgttcag gagggcagcctccatgtcagggatccagttggaggttctacagaatttctgtttgtccct ctcatcaagctcttttacactctactaattatgggaatcttccacaatggggatctgaaa cacatcttgcagttgattgagcccagggttttcaaagaagctatgagccaggaggatgaa agtgatttctcagagaaggagctgagttcggaggagctcaagtcagaaggagaggaagaa accagaggggagcaggtgccaaaggaaggactgcttcagatgaaacttcctgaacctgtt aaactacagatgtgtcatctactccagtacctgtgtgattgccaggtacgacaccggata gaagccattgtggcattttcagatgattttgtggccaagcttcaagagaatcagcgcttc cggtacaatgaggtgatgcaggccttgaacatgtctgctgccttgacagctagaaaaaca aaggaatttcgatcaccacctcaggagcagattaacatgctgctgaactttaaggatgat aaaaatgattgtccttgtcctgaagaaattcgggaccagctcttggatttccacgaagac ctaatgacacactgtggaattgagctagatgaagatggaaccttggatggaagcagtgat ttaaccattaggggtcgcctcctataccttatggaaaaagttacgtatctgaagaagaag caagctgagaagccagttgatgatgatgctaagacatcctctactcttcaacagttgatt tcagacacaatggtgcgctgggcccaggaatcagtaatagaagacccagagttagtcagg gccatgtttgtactgcttcatcgccagtatgatggtattggtggcttggttcgagccctg ccaaagacctatactataaatagtgtgtctgtggaagacacaatcaatcttctggcatcc ctcggccaaatacgttccttgctcagtgtcaggatgggaaaagaggaagagaaacttatg attcgtggattaggagacatcatgaataacaaagtattttaccaacatccaaatctcatg agagctttaggcatgcatgagactgtcatggaagtgatggtaaatgtgcttggtggagga gaatccaaggaaatcactttccccaaaatggtggcaaattgctgtcgtttcctatgttat ttttgccgcatcagcaggcagaatcaaaaagctatgtttgatcatcttagctatttgttg gaaaatagcagtgttggccttgcttctccttctatgagaggatcaactcctttagatgtt gcagcagcatctgtgatggataacaatgaacttgcactagctttaagggagcctgatttg gagaaggtggttcgctacttggctggttgtggattgcagagttgccctttgctgatttct aaaggctatccagacattggatggaatccagttgaaggagagcgatatttggattttctt cgttttgctgtattctgcaatggagagagtgtggaggagaatgcaaatgttgttgtcagg ctgcttattcgtcgaccagaatgttttggtccagctctaagaggagaaggaggcaatggt ctacttgctgccatggaggaagcaataaaaatatcagaagatccaacaagagatggacct tcgccaagtaatggatctagtaaaactcttgaaatggaagaacaagaagatgacactatt catatgggaaatgcaatcatgaccttttatgctgctttgattgatctcttaggacgttgt gcccctgaaatgcatttgatccatgctggtaaaggggaagccattagaatcaggtcaatt ctaaggtctttgattccactagaagatttggtgggcgtaattagtattcctttccacatg ccgaccatagctaaagatggaactgtggtggaacctgacatgtctgcggggttttgccca gatcacaaggcagccatggttttgttccttgacagggtctatggaattgaggatcaggat ttccttcttcaccttcttgaagttggctttctgccagatctccgtgctgctgcttcttta gatacagctgccttaagtgctacggatatggctttggctctgaatcgatacctttgcaca gcagttttgcctctgttgaccagatgtgctcctctttttgctggcacagagcaccatgct tccctcattgattccttattacatacggtgtacagactatcaaagggctgctctcttacc aaagctcagcgagattccattgaagagtgtttactgtctatttgtgggcaactgaggcct tccatgatgcagcatttgctgaggagattggtatttgatgttcccctattaaatgaacat gcaaagatgcctctcaagttgctgacgaatcattatgaaagatgctggaagtattattgt ttgccaggtggatggggtaattttggtgctgcctccgaagaagaacttcatttatccagg aagttgttctggggtatttttgatgctttgtctcaaaagaaatatgaacaagaattgttc aaactggctttgccttgtttgagtgcagttgcaggggccttacctccagactatatggaa tcaaattatgtaaatatgatggaaaaacagtcttcaatggattcagaaggaaactttaat cctcaacctgttgatacatccaacatcacgatccctgaaaagctagaatatttcattaac aaatatgcagaacattctcatgataaatggtcaatggaaaagtttgccaatgggtggaca tatggtgaaacatactctgaatctgcaaaagtgcaaccgttaatgaaacaatacaaatta ctctctgaaaaggagaaagaaatttatcgatggccaatcaaagaatcactgaaaaccatg ctagcatggggatggcggattgaaaggacacgggaaggagattctatggcactgtataat cggacacgccgcatatctcaaaccagtcaaatctcagtagatgcagcccatggttacagt cctcgagcaattgacatgagcaatgtcaccctctccagagatgtacatgctatggcagag atgatggctgaaaactaccataacatatgggcaaagaaaaagaaaatggagcttgaagca aaagtaggaggaggcaaccaccctcttcttgttccttatgacactctaacagccaaagaa aaagccaaggacagagaaaaagcacaggatattctgaaatttcttcagattaatggatat attgtctccagaggatttaaggacctggaattggacacaccttccattgagaaacgcttt gcctacagtttccttcagcaacttataagatacgtggatgaagcccatcagtatattttg gagtttgatggtggcagtagaggcaaaggagagcactttccatatgaacaagaaatcaag ttttttgccaaagttgtgctccctttgattgatcagtatttcaaaaatcatcgcctgtat ttcttgtctgcagcaagtagacctctcagcagtggaggccatgcctctaataaggagaag gaaatggtgaccagcctgttctgcaaacttggagttcttgtcaggcataggatttcactg tttggaaatgatgcaacatcaatagtcaactgtcttcacatactgggccagaccttggat gcgaggactgtgatgaaaactggtctggagtctgttaagatggcactgagagcttttttg gacaatgctgccgaggatctggagaaaacaatggaaaatctgaaacaaggccagtttaca cacagcagaaaccagcccaagggagttacacaaatcattaattataccacagtggctctc ctgccagtgctatcttcattatttgagcatattggacaacaccagtttggggaagatttg atattggaagatgttcaggtctcctgttacagaatattggccagtttgtatgctctggga accagcaagagtatttatgtagaacggcaacgatcagcactaggagaatgcttggctgcc ttctcaggtgcctttccagtggcttttttggaaactcatttgaacaaacataatatctac tcaatttacaataccaagaatgcaagagagagagcagttctcaatttgcctactagcgta gaagaggtttgcccaaatattccttccttggtgaagctaatggaagaaattgtggaattg gcagagtctggcattcgttacacacaaatgccacatataatggaagtgatcctgcctatg ctatgtagctacatgtcacactggtgggagcatgggccagaaaacaatcctgacaaggct gaaatgtgttgtacagccttgacatcagagcacatgaacactctgttgggtaacatactg aaaatcatctataacaaccttggtattgatgaaggagcctggatgaagaggttagcagtg ttttcccagcccatcataagcaaagcgaaaccacagctcttaaagacacacttcctgcca ctgatggataagctaaagaaaaaagcagcagtggttgtatcggatgaagaacatctaaga gcagaaggcagaggtgacatgtcggaggctgaactgctcatcctagatgagttcaccact ttggcacgggacctctatgccttctaccctttgttgattagatttgtggactataacagg gcaaaatggctgaaagagcccaacagtgaagctgaggaattgtttcgcatggtggctgaa gtcttcatttactggtcaaagtcccataatttcaaaagggaagagcagaactttgtggta caaaatgaaatcaataacatgtctttccttatcagtgacaccaaatctaagatgtccaag gcagcagtttctgaccaagagaggaagaagatgaagcggaaaggtgaccggtactctatg cagacctctctcattgtggcagcactgaagagattacttcccattggcctaaatatttgt gcccctggagatcaagaactaattgcactggccaaaaaccgattcagcatgaaagatact gaggatgaagtacgagacatcatacgcagtaatcttcatctccagggcaagtaccgagcc ttttatttcaagaaattgatgacgaaacttgcattcattttgacatggatgaagctcaag tcaccaaaatcttcttccagccatgctaattcacaccttgaaatgtcaactactcatgcc cttagaaaactacctatacaaaaaagctgtactttgatagaatgtgaggagtcctctgat caaaagacatctctgcctgtgcataaaaagtcttttgtggactatccattcatgatgatc cagtcaaatactcacacaaagactgtggatgtgacagttgttaagaaatggaaaatccga aaggtggaagaaaaacctgccaattgtggctttctaggttataataagctattattgagc gactgtcttgaggatcccgccattagatggcagatggcactttacaaagatttaccaaac aggaatgaagattcctcagatccagagaagacagtggaaagagttcttgatatagctaat gtactttttcatctggaacaggttgaacatcctcagcggtccaaaaaagcagtgtggcat aagctgctgtctaaacagaggaaaagagcagtggttgcctgctttagaatggcaccatta tataatctaccaaggcatcgagctgtcaatctctttcttcaaggctatgataaatcatgg attgagacagaagaacactattttgaagacaaactgatagaagatttagcaaaacctgga gaggaaccaacagaagaagatgaaaaccttaaaagagttgatcctttacatcaacttatt ctgctattcagtcgaacagccttaactgaaaaatgcaaactggaggaagattttctctat atggcttatgctgacattatggcaaagagttgccatgatgaagaagatgatgatggtgaa gaagaagtgaaaagttttgaagtcacaggatcccaacgcagcaaggaaaaagaaatggaa aagcaaaaacttctgtatcagcaagccagactgcatgaccgaggtgctgctgagatggtt cttcagacaatcagtgctagtaaaggtgagatggggccaatggttgcagctaccctaaag ctagggattgccatcttaaatggaggaaattctactgttcaacagaaaatgcttgactac ctcaaggataagaaagatgtgggtttctttcagagtcttgctggtcttatgcagtcctgt agtgttcttgacctaaatgcatttgaacgtcagaacaaagcagaaggccttggcatggtg accgaagagggatcagtcatcactcatgagcgtggagaaaaggtgatgcaggatgatgag tttacctgtgatctcttccgctttcttcaactactttgtgaaggacataactcagatttt caaaattatctgagaactcagactggtaacaacacaactgttaatattatcatttccact gtggattacttattgagagttcaggagtccattagtgatttctattggtattattctggg aaggatgttattgatgagcaaggacaacggaatttttccaaagccatccaggttgcaaaa caggttttcaatactctcacagagtatatccaggggccatgtactgggaatcagcaaagt ctggcacacagcaggctatgggatgctgtagttggttttcttcatgtgtttgcccacatg cagatgaagctgtcccaggattccagtcaaattgaattactgaaagaattaatggatctt caaaaggatatggttgtcatgttgctgtctatgctggaaggtaatgttgtgaatggaact attggcaagcagatggttgatatgcttgtggaatcgtccaacaatgtggagatgattctg aagttctttgatatgttcttaaaactgaaggatttgacttcctctgatgcattcaaagag tatgacccagatggtaaaggcataatttcaaaaagggatttccacaaagcaatggaaagc cataaacattacactcagtctgaaactgagtttctgctatcctgtgctgaaactgatgag aatgagactctggactacgaggagtttgtgaaacggttccatgaacctgccaaagacatt ggtttcaatgttgctgttctcctgaccaacctctcagaacacatgccccatgatacccgc ttgcaaacttttcttgaactgtcagagagtgtgctgaattactttcagcctttccttgga cgcatagaaatcatgggtagtgcaaagcgcattgaacgagtatattttgaaataagtgag tcaagtcggactcagtgggagaaacctcaggtaaaagagtcaaagagacaatttatattt gatgttgtaaatgaaggtggggagaaagaaaagatggagctttttgttaatttctgtgag gataccatctttgaaatgcaactggctgctcagatttctgagtcagatctgaatgaaagg tcagctaataaagaggaaaatgagaaagataagcctgaggagcaggatcctggaatgggt ttcttctctcttgtaactatgaagttagcattagtagctctcaagtataatttaatgact cttatgaaaatgcttagcatgaaaagcctgaagaaacagatgaaaaaagtgaagaaaatg accatgaaggacatgattatggctttgttttcttcctactggagcattttgatgggctta ctgcattttgcttgtagtgtcttccgtggcttctttcgcatcatatgcagtttgctgctt ggaggaagcctagtagaaggagcaaagaagatcaaggtggctgaactattagctaatatg ccagatcccacgcaggatgaggtgcgtggggaaggagaagagggggagaggaagcccaca gaaactgcattgcctgcagaagacttgacagatttgagaactttatcagatgagagtgat ctactatcagatatatttggtttggatttgaaacgggaaggtggacagtataaattgatc cctcataatccaaacgctggtttgagcgatttgctgagcactccttccttagctccaatg cctgaggaacaggaaaaaatccaggaacaaatgaaagaagatgaaaaggaagagaaggag gaaacaaaatctgaacctgaaaaagcagaaggagaggatggagaaaaagaagagaaagcc aaggaagacaaagggaaacagaaattaagacagcttcatactcatagatatggagaaccg gaagttcaggaatcggctttctggaagaaaataattgcatatcaacaaaagcttctgaac tattttgctcgaaacttttataacatgaggatgttggcattgtttgttgcttttgccatc aacttcatccttcttttctataaggtctccacctctgctgtgacagaagaaaaggaagtt cctgtggtgtctactggagaaagtatgaagttgaacagcttggagagtgacagccagagg gtcattgcagttcattatgtcctagaagaaagcagtggctacatggagcccacgctgcgg attttggccatattacacacaatcatctctttcttctgcatcatagggtattattgtttg aaagttccactggttatttttaagagggaaaaggaagtagcaaggaaattggaatttgat gggctgtatataaccgaacagccctcagaagacgatattaaagggcaatgggatagactt gtaatcaacacacagtcttttccaaacaactattgggacaaatttgtgaaaagaaaggtc atggataaatatggtgagttttatggccgtgacagaatcagtgagttactaggaatggac aaagctgctcttgattttagtgatgctcgagaaaagaagaaaccaaagaaggatagctcc ttatctgctgtgctaaactctgttgatgttaagtatcagatgtggaaattaggagttgtt ttcactgataattctttcctttacctagcttggtacatgaccatgtcagtccttggccat tacaacaattttttctttgctgctcatcttcttgacattgcaatggggttcaagacgtta cgaactatcctgtcatcagtgacccacaatggtaaacagcttgtcctaacagtgggatta ctggcagtagtggtatacttgtacacagtagtggcattcaatttttttcgcaagttctac aacaagagtgaagatggtgatatgccagacatgaaatgtgatgatatgttaacatgctac atgtttcacatgtatgttggagtacgtgcaggtggaggaattggtgatgaaatagaggat ccagcaggagatgaatatgagatctatcggattatctttgatatcactttcttcttcttt gtgattgtcatcctgcttgccattattcaaggtttaattattgatgcttttggtgagtta agagatcagcaagaacaagttaaagaagacatggagacaaagtgctttatctgtggaata ggaaatgattactttgatacagtgccccatggctttgaaacacacacactgcaggagcac aacttggccaattatttgtttttcctgatgtatcttattaataaagatgaaacagagcat acaggacaggaatcctatgtatggaaaatgtatcaagaacggtgctgggagttttttcct gctggtgattgcttccgaaaacagtatgaagaccagctcaactaa

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