Aythya fuligula (tufted duck): 116490323 Help Entry 116490323         CDS       T07966                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism aful  Aythya fuligula (tufted duck) Pathway aful04020   Calcium signaling pathway aful04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:aful00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     116490323 (RYR3)    04020 Calcium signaling pathway     116490323 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:aful04040]     116490323 (RYR3) Ion channels [BR:aful04040]  Voltage-gated cation channels   Ryanodine receptor    116490323 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR Ins145_P3_rec SPRY RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 TBK1_ULD Motif Other DBs NCBI-GeneID:  116490323 NCBI-ProteinID:  XP_032045290 UniProt:  A0A6J3D4M5 LinkDB All DBs Position 5:complement(39121610..39340470) Genome browser AA seq 4875 aa AA seqDB search MAEGGEGGEDEIQFLRTDDEVVLQCVASIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCICNFVLEQSLSVRALQEMLANTGDNASEGFIKKAAQGGHRTLLYGHAILLRHSFSE MYLTCLTSSRSQTDKLAFDVGLRENAAGEACWWTIHPASKQRSEGEKVRIGDDLILVSVS SERYLHLSMSNGSIQVDASFMQTLWNVHPTCSGSNITEGYLLGGHVVRFFHGHDECLTIP STDQNDSQQKKVLYETGGAGVRARSLWRVEPLRISWSGSNIKWGQPFRLRHITTGMYLAL NDDEGLVMLDREKSDTTSTAFCFRASKELKEKQDSTLKRDIDGMGVPEIKYGDSVCFVQH VASALWLTYKAQDAKSARLGPLKRKVILHQEGHMDDGLTLQRCQHEESQAARIIRNTTSL FSQFISGNNRTLSPIALPVEEMAQTLQDLITYFQPPEEDLGHEDKQSKLRSLKNRQNLFK EEGMLALVLNCIDRLNDYNSAAHFAEIAREENGTTWKEILNLLYKLLAALIRGNRNNCTQ FSSNLDWLISKLDRLESSSGILEVLHCILIESPEALNIIAEEHIKSIISLLDKHGRNYKV LDVLCSLCVCNGVAVRANQNLICDNLLPRRDLLLQTRLINDVTSIRPNIFLGVAEGSAQY KKWYFELIIDQVDPFLTAEPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDDLYSYGFDGL HLWSGRVPRAVASVNQHLLSSDDVVSCCLDLGVPSISFRINGQPVQGMFENFCTEGFFFP VVSLSAGVKARFLLGGRHGEFKFLPPAGYAPCYEALLPKEKMKLEPVKEYKRDSDGVRDL LGTTQFLSQASFIPCPIDTSQIALPFHLEKIRDKLAENIHELWGMNKIELGWTYGKIRDD NKRHHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIVHANPAAEEDLKKVKLPKNY MMSNGYKPAPLDLSEVKLLPSQEFLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNP RLVPYALLDERTKKSNRDSLREAVRTFAGYGYSVEPPDQEIADQTTEKVSIDKIRFFRVE QSYAVKSGKWYFEFEAVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSKGQRWHQGSGF FGRSWQPGDVVGCMINLDDKSIIFTLNGELLITSKGSELAFADFGIESGFVPICALGLSQ IGRMNLGMDASTFKYYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKNHPHVEIW RIDGTIESPPRLKVTHKTFGTQNSNSDMIYCRLSMPIEFRSSFNFGMGVENASSDIFQKR KHSQEISVPSTTYFYSLRIFAGQDPSCVWVGWVTPDYHFYSENFDLSKNCTVTVTLGDER GRVHESVKRSNCYMVWGGDITSNSQRSGRSNVDLEIGCFVDLATGMLSFTANGKELGTCY QVEPNTKLFPATFVQPTSTNLVQFELGKLKNTMPLSAAIFKSEERNPIPQCPPRLDVQTI TPVLWSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLM KFHYHTLKLYSSVCALGNTRVAYALCSHVDVSQLFYTIDNQYLPGLLRSGFYDLLISIHL EHAKQAKLMMNNEFIIPVTEETRTIRLYPDETKKHGLPGVGLSTCLKPSFHFSTPCFIVT SEEHQTSSPEIPLDTLKSKAISMLTEAVQCSGTHIRDPVGGHIAFQFVPVLKLIATLLIM GVFDDDDVKQVLILIDPNVFGDHKEETEEGTEKEEVTQVEEKAVEAGEKAIKETKAPTTG LLQTRLPESVKLQMCHLLNYFCDCELQHRVEAIVSFADRYVSKLQYNQKYRYNELMQALN MSAALTAKKTKEFRSPPQEQINMLLNFQLGEDCPCPEEIRDELYDFHDDLLIHCGIPLEE EEEEEEDSTLTGKLRSLIYKIKGPPKAEKVEPREEEEKSPTTLKELISQTMVRWSQEDQI QDPELVRIMYTLLRRQYDSIGELLQALRKAYTISAASVKDTINLLAALGQIRSLLSVRMG KEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMDVMVNVLGGDKSQQIAFPKMVAS CCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLAFPSMRGSTPLDVAAASVMDNNELAL ALEEPDLDKVVTYLAGCGLQSCPVLLAKGYPDIGWNPIEGERYLSFLRFAVFVNSESVEE NASVVVKLLIRRPECFGPDLRGEGGNGLLAAMQEAIRISENPSRDLPSQGYKREGDEEEE EEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQSGKGEAIRIRSILRSLVPTEDLVGIIS IPLKLSTVNKDGTVNEPDMSANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLR ASASLDTVSLSTTEAALALNRYICSAVFPLLKRCAPLFSGTEHHASLVDSMLHTIYRLSK GRSLTKAQRDTIEECLLAICHHLRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTNHYEQC WKYYCLPSGMGSYGIAAEEELHLTEKLFWGIFDSLSHKFLSLLQKYDPELFRMALPCLSA IAGALPPDYLDTRIRSTLEKQTSVDPEGNFDPKPVSTANLVLPEKLEYIVSKYAEHSHDK WAFDKTNNGWKYGVSLDENTKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAMGWSLER TKEGGETILHQRENEKLRSISQSSQGNGYSPAPLDLSNVVLSRELQGMVEVMAENYHNIW AKKKKMELESKGGGSHPLLVPYDTLTAKEKSRDREKAQELFKFLQVNGIIISRGLNDMDL DASSMEKRFAFKFLKKILKYVDSAQEFIAHLEAIVTSGKTEKSPHDQEIKFFAKVLLPLV DQYFTNHCLYFLSSPTKTLSSSGYASNKEKEMVASLFCKLAALVRHRISIFGSDSTTMVN CLHILAQSLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVS QNINYTTVALLPVLTSIFEHISQYQFGVDLLLGDVQVSCYRILCSLYSLGTGKNIYVERQ RPALGECLASLAAAIPVAFLEPSLNHYNPLSVFNTKSARERAILGMPDTVEEMCPEIPQL DGLIKEINDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGSESVPESAGPFCTMITSE HLSIILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLKTHFIPTLEKLKKKAI KIVMEEEQLKADSKTDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRANWLKKPDAD SDELFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDTKSKMSKSGGQDQERKK SKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRYSHRDTDEEVKEHLRN NLHLQEKSDDPAVKWQLNLYKDILKNDEPSDPEKNVERVQRISAALYHLEQVEQPLRSKK AVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQNYWIETEEYSFEEKLVQDL ATPPKKDEEEEEDTEKKQPDPLHQIILYFSRNALTERSKLEDDPLYIAYSAMMAKSCQEE EEEEEEEKEKTFEEKEMEKQRTLYQQARLHDRGAAEMVLQMISASKGHTGPMVVETLKLG IAILNGGNTIVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTE EGTLIVRERGEKVLQHDEFTRDLFRFLQLLCEGHNNDFQNYLRTQMGNTTTVNIIISTVD YLLRLQESISDFYWYYSGKDVIDESGQRNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLA HSRLWDAVVGFLHVFANMQMKLSQDSAQIELLKELLDLLKDMVVMLLSLLEGNVVNGTIG KQMVDTLVESSSNVELILKFFDMFLKLKDLTNSDAFKEHDPDGKGIISKKEFQKSMEAQK QYIQSEIEFLLSCAEADENDMFNYLDFVERFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQ SLLEPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRMQWEKPQVKESKRQFIFDV VNEGGEQEKMELFVNFCEDTIFEMQLASQISETDSAERPEEEEEEESCYVVDIGDDEEEE KSLESPSAFAMACTAVKKNVTNFFKMVTVKNLRKQYRKVRKMTVKEMVKVFFSFFWILFV GMFQLFFTIVWGIFQILWSTVFGGGLVEGAKNIKVTKILGDMPDPTQFGIHDDVTEAEKA EGAEHGIRAELVQFVKGEKAETDIISDIFGIPTKKEGGSKHGHDAGLGDIAEMLGSDIQS SLENTVRKKKGLQLSEIAKEAEAERKVEAEKADMEDGEKEDKAKEVQPEQLEEGKVKKKK RRHGQKIEKPEAVMANFFKALEIYQTKMLHYLARNFYNLRFLALFVAFAINFILLFYKVT EEPLDEVEEDSNLWNTFDEEEEEEGMVFFVLEESTGYMAPALRALAVIHTIISFVCVIGY YCLKVPLVVFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVK RKVINKYGDLYGAERIAELLGLDKNALDFSPVEESEPEEASLLSWLSSIDTKYHIWKLGV VFTDNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVG LLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIE DPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICG IGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESFVWKMYQERCWDFF PAGDCFRKQYEDQLG NT seq 14628 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggtgaaggaggggaagatgaaatacagttcctacgaactgatgacgaa gtagtacttcagtgtgttgccagcatacacaaagaacaaaggaagttttgcttggcagct gagggacttgggaatcgcctgtgctttttggaaccaacatcagaagctaaatatgttcct ccggacctttgcatctgtaattttgtacttgaacagtccctgtctgtcagagcccttcaa gaaatgctggccaacacaggggataatgccagtgaagggtttataaaaaaggcagctcaa ggtggtcacagaaccctgctatatggtcatgctatactacttcgacattcattcagtgaa atgtatttgacttgtttaacgtcatcaagatcccagacagataaacttgcatttgatgtg ggactgagagaaaatgcagcaggtgaagcatgctggtggacaatacaccctgcatctaaa caaaggtcagaaggagaaaaagttcgaataggtgatgatcttatcctggtcagtgtgtcc tctgaaagatacctgcatctttccatgtcaaatggaagtattcaggtggatgcctccttt atgcagacgctttggaatgtacatcctacatgctcaggaagcaatattacagaagggtat cttcttggtgggcatgtagtacgttttttccatggccatgatgagtgtttgacaattcca tctacagatcagaatgactcacagcagaagaaagtactttatgaaactggaggagctgga gttcgagcaaggtctttgtggagagtagaaccacttcgaataagttggagtggaagtaac atcaaatggggacaacctttccgtcttcgacatattacaacaggaatgtacttggctctg aatgatgatgaaggacttgtaatgttagacagagaaaagtcagacacaacatctactgct ttctgttttagagcatcaaaggagctaaaagaaaaacaggattccactcttaaacgtgat attgatggaatgggagtcccagaaataaagtatggtgattcagtctgttttgttcaacat gtggccagtgctttatggttgacttataaagcacaggatgctaaatcagcacgtttaggt cccttgaaaagaaaggttatattgcaccaagaaggccatatggatgatggtctaacctta caaagatgtcagcatgaagaatcccaggctgctcgaatcattcgcaatactacaagctta ttcagccagtttataagtggaaacaacagaacactatcacccatcgccctgcctgttgag gagatggctcaaactctgcaagacctgattacttacttccagcctcccgaagaagacctg ggacatgaggataaacaaagcaagcttcggtcactgaaaaacagacagaatctatttaaa gaagagggcatgctggcactagttttgaattgcattgatcgtttaaatgactacaacagt gcagctcattttgcagaaattgcaagagaagaaaatggtaccacatggaaagaaatttta aatctcctttacaaattgttagctgccctcattcgtggcaacagaaacaattgtactcaa ttttccagtaaccttgattggctaataagtaaattggacagactagaatcttcctcaggt attttggaagtgttgcactgcattttgattgaaagcccagaagctttaaatataatagct gaggagcatataaaatctattatttcattgttggataaacatgggcgcaattacaaggtt cttgatgtgctttgctctctctgtgtctgtaatggagttgcggttcgtgccaatcaaaat ttgatctgtgacaatctattgcctagaagagacttactcttgcaaacacgtttgattaat gatgtgacaagcataaggccgaacatatttctgggtgttgctgagggctctgcacaatac aagaagtggtactttgaattaataattgatcaggttgatccattcttgacggcagaaccc acccatttacgagttggatgggcctctacttcaggttatgctccctatcctggaggagga gaaggatggggtggcaatggtgttggggatgacctatactcttacggttttgatggcctc catctgtggtctggtcgagtacccagggctgtagcatctgtcaatcaacatttgttgtca tctgatgatgtggttagctgctgcttggatttaggtgtgcccagcatttcattccgcatt aatgggcagcctgtacaaggaatgtttgagaacttctgtactgaagggtttttcttccct gttgtaagcttatcagcaggtgtaaaagctcgtttcttattgggtggacgtcacggagag tttaaatttctacctcctgctggctatgctccctgctatgaagccttgcttccaaaagag aagatgaaactggaaccagtgaaagaatacaagagagattctgatggagtgagggatttg ctgggtacaacacaattcctctcccaagcttcctttatcccttgtcctatagacaccagt cagattgctcttccttttcatcttgaaaagatcagggacaaactagctgaaaatatccat gaactgtggggaatgaataaaatagaacttggctggacatatggcaagatacgggatgat aataaaaggcatcatccttgtcttgtagaattctcaaaattacctgagacagagaagaat tataatctgcaaatgtcaactgaaactctcaaaacccttttggcccttgggtgtcacatt gttcatgctaatccagcagcagaggaagatcttaaaaaagtcaagcttcctaaaaattac atgatgtcaaatggatataaacctgcccctcttgatctttctgaagtgaaattgttacct tctcaagaattcctagttgacaaactagcagaaaatgcacataatgtctgggcaaaagac agaataaagcaaggatggacctatggcattcagcaggatcttaagaacaaacgtaatcct cggctagtgccatatgcattattagatgaacgtactaaaaaatcgaacagagatagcctc cgtgaagctgttagaacatttgcaggctatggttatagtgttgagccacctgaccaagaa atagctgatcaaacaacggaaaaagtcagcattgacaagatacgttttttcagagtcgaa cagtcttatgcagtgaagtctggaaagtggtacttcgaatttgaagctgtgacaggtgga gacatgcgtgttggctgggccaggccaggctgtagacctgacatagaactgggagctgat gaccaagcatttgttttcgaaggaagcaaaggccagcgttggcatcaaggcagtggattc tttggacgaagttggcaaccaggagatgtggttggttgcatgataaacttggatgacaaa tccattatctttactttgaatggagaattgcttataaccagtaaaggttcagaacttgca tttgctgactttggaatagaaagtggttttgttccaatttgcgcactgggtctgtctcag attggacgtatgaaccttggaatggatgccagtacattcaagtattatacaatgtgtggc cttcaagaaggttttgaaccttttgcagtaaatatgaaccgagatgttgctatgtggttc agtaaacgcttaccaacatttgtcaatgtgccaaaaaatcatcctcacgtagagatatgg agaattgatggaaccattgagagtccacctcggttaaaagttactcacaaaacgtttggc acacagaacagcaattcagacatgatatattgtcgtttgagtatgcctattgagttccgt tcgtcattcaactttggcatgggtgtggaaaatgcctcatctgatatttttcaaaaacga aaacacagccaagaaatttctgttccttctactacgtatttttattcgttgcggatattt gctgggcaagacccatcctgtgtctgggttggctgggtaacaccagactatcatttttac agtgagaattttgacctaagtaaaaattgtacagtgacggttactttaggtgatgagaga ggcagggttcatgaaagtgtgaagcgcagtaattgctatatggtttggggaggagatata acttctaattcccagagatcaggtcgtagcaatgttgatttagaaattggatgctttgtt gacctagctactggaatgttgtcattcacagccaatggaaaagagcttggcacttgttat caggttgaacccaacacaaaactttttccagcaacttttgtacagcctacaagcactaac ttggttcagtttgaacttggtaaattaaagaataccatgcctttatcagcagcaattttt aaaagtgaggaaagaaatcctattcctcagtgcccccctcgccttgatgtgcaaacaatt acacctgttttatggagcaggatgcctaacagctttctcaaagtggaaactgagcgtgtc agtgaacgtcatggatgggttgtgcagtgtttggaacctctgcagatgatggcacttcat atcccagaggaaaacagatgtgtcgatattttggaactatgtgaacaagaagatttgatg aagtttcactatcacactttaaaactctatagctcagtttgtgctctaggtaacactaga gttgcttatgcactttgtagccatgtggatgtatctcagttattttacacaatagataat caatatttacctggactcctacgttctggattctatgacttgttgattagtatacatttg gagcatgccaagcaagccaagctcatgatgaacaatgaatttatcattccagttacagag gaaactcgaactattagattatatcctgatgaaacaaagaagcatggtttacctggagta gggcttagcacttgtctgaaaccaagctttcatttttctactccttgctttattgtgacc agtgaagaacatcagacatccagcccagagataccccttgatacacttaaatctaaagcc ataagtatgctaacagaggcagtacagtgtagtggtactcatatacgagaccctgttgga ggacacattgcattccagtttgttcctgttcttaaactaatagcaacactgctcataatg ggggtttttgatgatgatgatgtgaagcaggtgttaattctcattgatccaaatgtattt ggagatcacaaggaagaaacagaagagggtacagaaaaggaagaagttacacaagttgaa gaaaaagctgtagaagctggagaaaaagcaataaaagaaaccaaagctcctacaacaggc ttgttgcagacaagattaccagaatctgttaagcttcagatgtgccatttactcaattat ttctgtgactgtgagctgcaacacagagtggaagcaattgtatcgtttgcagaccgttat gtatcaaaattgcagtataatcagaaatacaggtataatgaactcatgcaagccttgaac atgtctgcagctttgactgccaagaagactaaagaatttcggtctcctccacaagaacag attaatatgctgctgaattttcaactgggagaggattgtccctgtccagaggagattcgg gatgagctgtacgacttccatgatgatcttctaattcactgtggtattccactagaagag gaagaagaggaagaggaagattctaccttgactggcaaactccgttcgttaatatacaaa atcaaaggtccaccaaaagcagaaaaagtagagcctagagaagaagaagagaaatcacct actacactgaaggaactcatatcccagactatggtacgctggtctcaggaagatcagatt caagatccagaattagttcggattatgtataccctccttcgtaggcaatatgacagcatt ggtgagctacttcaagctctgaggaaagcatacaccattagtgctgcctctgtgaaggat acaattaatctgcttgctgcactgggccagattcgctcacttctcagtgtcagaatggga aaagaggaggaattgctaatgattaatggattaggggatataatgaacaacaaggtgttt tatcagcatcctaacttaatgagagtcttgggcatgcatgagacagttatggatgtgatg gtgaatgtgcttggaggagataagtctcagcagatcgcttttcctaagatggtggcaagc tgttgtcgattcctgtgctacttctgtcgaattagtcgtcaaaaccaaaaagccatgttt gagcatcttagttacttactggaaaacagcagcgttgggctggcatttccttcaatgaga ggttcaacaccactagatgttgcagcagcctccgtaatggacaacaatgagcttgcacta gcactggaagagccagatctggataaagttgttacttatttggctggttgtggcctgcag agttgtccagtattgctagctaaaggatatccagacattggatggaatccaatagagggt gaacgttacctgtcattcttaagatttgcagtttttgttaacagtgaaagtgttgaagaa aatgcaagtgttgttgtcaagctccttattcgacgaccagagtgctttggaccagacctt agaggagaaggaggaaatggtttactggcagctatgcaagaagctatcagaatctcagag aatccttctcgtgaccttccctcacaaggatataagagagaaggtgatgaggaggaggaa gaggaggagattgtgcacatgggcaatgcaatcatgtcattttactcagctctcatagat ttacttggacgctgtgcaccagaaatgcatcttattcaaagtggaaaaggtgaagctatt cgaatcaggtcgatcctccgatctctagtgccaactgaagatttggttgggattataagt ataccgctaaagctgtcaacagttaacaaagatggcacagtaaatgagccagatatgtct gcaaatttctgtcctgatcataaagcaccaatggtactcttcttggaccgtgtatatggt attaaggaccaaaccttcctccttcacctattggaagttggatttttaccagatttaaga gcttctgcctctctggatacagtttctctaagtaccacagaggcagctctcgcactaaat agatatatttgttcagctgtgtttccattactcaaaagatgtgctcccctcttttctgga acagagcatcatgcctctttggttgactccatgcttcacacaatatataggttatccaaa ggacgttcccttacaaaagcacaacgagacactattgaagaatgcctgcttgctatttgc caccacttacgtccctctatgctacaacagctgttgagaaggctagtttttgatgtacca ctactcaatgagtactgtaaaatgcctctcaagcttctgacaaatcactatgaacagtgc tggaagtattattgtctaccttcaggaatgggaagctatggaattgcagcagaagaagaa ttacatttaactgagaaacttttctggggaatatttgattccttgtctcataagttccta tctctcctgcagaagtacgatccagagctctttcgaatggccttgccttgtctaagtgct atagctggtgctttgcctcctgattatttagatacacgaattagatcaactttggaaaag cagacttcagtggatccagaaggaaattttgatcccaaacctgtcagtacagcaaacctt gtacttcctgaaaagttggagtatattgtcagcaagtatgctgaacattcccatgataag tgggcctttgataagactaataatggatggaaatatggtgtttcactggatgaaaatacg aagactcacccattaataagacctttcaaaactttaacagaaaaggaaaaagaaatttat cgttggcctgctagagaatcactgaaaaccatgttggccatgggatggagcctagaaagg accaaagaaggaggagaaacaatattacatcagcgtgaaaatgaaaagctccgcagcata tctcagtctagccagggaaatggatatagcccagcaccacttgatctctctaatgtggtg ctttctagggagcttcagggaatggttgaggtaatggcagaaaactaccataatatatgg gccaaaaagaagaaaatggagttggaaagcaaaggtggaggtagtcatcctttattggta ccttatgacacgttgacagccaaggagaaatcacgggaccgtgaaaaggcacaggagctg tttaaattccttcaagtgaatggtataatcatatctcggggtctgaatgacatggatttg gatgcttcatccatggaaaagaggtttgcctttaagtttctgaagaaaattttaaaatat gttgactctgctcaagagttcattgcacatttggaagccattgtaaccagtggaaaaact gaaaaatctccacatgaccaagaaataaaattctttgcgaaagttcttttaccattagtt gatcagtactttacaaatcactgcctgtacttcctgtcttctccaacaaaaacactcagt agcagtggatatgcatcaaataaggaaaaggaaatggtagcaagcctgttctgcaaacta gctgctcttgttagacataggatctcaatttttggtagtgattctacaacaatggttaac tgcctgcacatcttagctcagtctcttgacactcgaactgttatgaaatcgggatctgag ttagttaaagctggattacgtgccttttttgaaaatgcagctgaagatctggaaaaaact tcagaaaatcttaaacttggaaaatttacccattcacgaacacaaatcaagggtgtttca cagaatatcaattatactacagtagcattgttacctgtcttgacatcaatttttgagcat atttcacagtatcagtttggagttgatttacttttgggtgatgtacaggtttcatgttat agaattctttgtagcctctattcccttgggactgggaagaacatctatgttgaaaggcag cgccctgcacttggtgagtgcttagcatctcttgcagcagccattccggtagcatttctt gaaccttctctcaaccattacaacccattgtctgtcttcaacacaaaaagtgcaagagaa agagcaattttaggtatgcctgatacagtagaggagatgtgtccggagatcccccagttg gatggactaataaaggaaattaatgatttagcagagtctggagcaaggtatactgaaatg cctcatgtaattgaggttatcttacccatgctatgcaactatttgtcctactggtgggaa cgagggtctgagagtgttcctgaaagtgctgggcctttctgtacgatgataacatctgaa catctaagcatcattctgggaaacattctgaaaatcattaacaacaatctgggaatagat gaagcatcttggatgaagagaattgcagtttatgctcagcctatcatcagcaaagccaga ccagatctgctgaaaactcactttattccaacactggagaaattgaagaagaaagctata aagattgtgatggaagaggagcaactgaaagcagacagtaaaactgacacccaggaagct gagctactcattctcgatgaatttgctgttctttgtagagacctctatgccttctatcca atgttgatacgttatgtagacaacaacagagccaattggctaaagaaaccagacgcagac tctgatgaactcttccgaatggtagctgaagtgtttatcctgtggtgtaaatcacataat ttcaaaagagaagaacaaaattttgtgattcaaaatgaaatcaacaacttggcattttta acaggagataccaaaagcaagatgtctaaatctggaggacaagatcaagaaagaaagaaa tcaaagcgtagaggggatttgtactccatacaaacatccttgattgtagctgcacttaaa aagatgcttcctattggcttgaatatgtgtactcctggagatcaagagctcatctctttg gctaagactagatacagccatagggacactgatgaagaagtcaaagagcatttacgtaac aacttacatttgcaggaaaagtctgatgatccagctgtgaaatggcagttaaatctgtat aaagacattttgaaaaatgatgagcctagtgaccctgagaaaaacgtggaacgtgtgcag aggatatcagctgctctctatcatctggagcaggttgaacaaccactaagatccaagaaa gctgtttggcataaactcctgtcaaaacaacgcaaaagggctgttgttgcttgttttaga atggcaccattgtacaacctgcccaggcaccgttctattaacctcttcctccatggctat cagaactattggatagaaacagaggaatattcatttgaggagaaactagttcaggatttg gctacacctccaaaaaaagatgaagaagaagaggaagatactgagaaaaaacagcctgat ccacttcatcagattatcctttattttagtcgcaatgctctcacagagaggagcaaacta gaagatgatcctttatatatcgcctattctgccatgatggcaaagagctgtcaggaagaa gaggaggaagaagaggaagaaaaagagaagacatttgaggagaaagaaatggaaaagcag agaacgctttaccagcaagcccgtttgcatgatcgtggagctgctgagatggtccttcag atgattagtgcaagcaaaggtcatacaggacccatggttgttgaaacattaaaacttggt attgctattctaaatggtgggaataccatagttcaacagaaaatgttagactacctgaag gagaaaaaggatgctggattctttcaaagtctctctggcttgatgcagtcctgcagtgtt cttgacttgaatgcgtttgagagacaaaataaagcagaaggcctgggaatggttactgaa gaaggaactctcatcgttcgtgagcgtggtgaaaaagtgttgcagcatgatgaatttact cgagatctatttagatttttacaactgctctgtgaagggcataacaatgattttcaaaat tacctacgtactcagatgggcaacaccacaacagtgaatattatcattagtactgttgac tatctcttgcgtcttcaggaatcaatcagtgacttttattggtactattcaggaaaagat gtcattgatgaatcaggacaacgtaacttctctaaagctttggctgtcaccaaacaaata ttcaattcccttacagaatatattcagggcccttgcataggtaaccaacaaagtctggct catagtaggctgtgggatgcagttgttggctttcttcatgtctttgccaatatgcagatg aaactttcacaggactctgctcagattgaattacttaaagaactgctcgatctactaaag gatatggtagtcatgctgttgtcactgctcgaaggtaacgttgtaaatggaacaattgga aaacaaatggtcgatacgcttgtagaatcatctagcaatgtagaattgattttgaaattt tttgacatgttcctcaaattaaaagacctaactaactcagatgctttcaaagaacatgac ccagatggtaaaggcataatttcaaagaaggaattccagaagtcaatggaggctcaaaaa caatatatacagtcagagattgaattcctgctatcctgtgcagaagctgatgaaaatgac atgtttaactatcttgattttgtggaaagattccatgaaccagccaaagacattggattt aatgtagcagtattgctaacaaacctttcagaacacatgcctaatgattcacgccttcag agcttacttgaacctgcagaaagtgttcttaattattttgaaccataccttggccgtatt gaaataatgggtggagccaagaaaatagaaagagtttactttgaaattagtgagtccagt agaatgcagtgggagaaaccacaggtgaaggaatccaaaaggcagttcatatttgatgtt gtaaatgaaggtggagaacaagaaaagatggagctctttgtgaatttctgtgaagacaca atctttgaaatgcagttagcatcccagatctctgaaactgattcagctgagaggcctgag gaagaggaagaagaagagtcttgctatgttgtagatattggagatgatgaggaagaagaa aagtccctggaatctccttcagcttttgcaatggcctgtactgcagtgaagaagaatgtt accaacttttttaaaatggtcactgtgaagaacctaagaaaacagtacaggaaagttaga aagatgacagtaaaagagatggtgaaagtttttttctcctttttctggatcctatttgta gggatgttccaactgttctttactatagtgtggggaattttccagattctttggagcact gtatttgggggtggcctggtcgaaggagccaaaaacattaaagtcactaaaatattaggg gacatgcctgacccaacacagtttggaatccatgatgatgttacagaagcagaaaaagct gaaggtgctgagcatggcattagagctgaacttgtccagtttgtaaagggcgaaaaggca gaaactgacattatctctgatatttttggcattcctaccaaaaaagaaggtggctcaaaa catggtcatgatgctggacttggggatattgcagaaatgcttggttctgatatccagtct tctttggaaaacacagttcgtaagaaaaaaggattacagctatctgaaattgcaaaagaa gctgaagcagaaagaaaagtggaagctgagaaggctgacatggaagatggtgagaaagaa gataaagcaaaggaagtacagcctgagcagctggaagagggtaaggtgaagaaaaagaag agaaggcatggacaaaaaattgagaaacctgaggctgttatggctaacttcttcaaagct ttggaaatttatcaaacaaaaatgctgcactacctagcaagaaatttttataacttacgg tttcttgctctatttgttgcatttgctatcaacttcattctactattttacaaggtgaca gaagagccacttgatgaggtagaggaagactctaatctctggaacactttcgatgaagag gaagaggaggaaggcatggtgttttttgttttagaagaaagtacgggttacatggcacct gctctcagagcattggcagttattcataccatcatctcctttgtctgtgtgattggatac tattgcttaaaggtccctctggttgtattcaaaagagaaaaggaagtagctaggaagctg gaatttgatggattatacataactgaacagccatctgaagatgatattaaaggacaatgg gatcgcctggttataaacacaccgtcctttcctaacaattactgggacaaatttgtaaaa cggaaggttattaacaagtatggagacttatatggagcagagcgcatagcagaacttttg ggtttggacaaaaatgcccttgattttagtccagtggaagagagtgaaccagaagaggcg tctcttctatcatggttaagctccattgatacaaagtaccacatttggaagctcggtgtt gttttcactgataattcatttttatacttagcttggtacacaactatgtctatccttggg cactacaataacttcttctttgctgctcatctgctggatattgctatgggtttcaagact ttgcgaaccattctgtcttcagtcactcacaatggcaaacagcttgtgctcactgtagga ctcctggctgtagtagtgtatctttacaccgttgtggcgttcaactttttccgcaaattc tacaacaaaagtgaagatgaagatgaaccagacatgaaatgtgatgacatgatgacgtgt tacctgttccacatgtatgtgggtgtaagagctggtggtggcattggggatgaaattgag gatcctgcaggagacccttatgaaatgtatcgaattgtctttgacatcacatttttcttc tttgtcattgttatcctactggccattattcaaggtctgattattgatgcttttggtgaa ttaagagaccagcaagaacaagtgagagaagatatggagaccaaatgttttatttgtgga attggcaatgactattttgacacaaccccacatggctttgaaacacatactttgcaagag cacaacttggcaaactacctgttctttttaatgtatctcataaacaaggatgaaactgag catactggccaggaatcatttgtgtggaagatgtaccaggaaagatgttgggattttttc ccagcaggagactgcttccggaaacagtatgaggatcaacttggctaa

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