KEGG   Antechinus flavipes (yellow-footed antechinus): 127549861
Entry
127549861         CDS       T08818                                 
Name
(RefSeq) RAC-alpha serine/threonine-protein kinase
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
afz  Antechinus flavipes (yellow-footed antechinus)
Pathway
afz01521  EGFR tyrosine kinase inhibitor resistance
afz01522  Endocrine resistance
afz01524  Platinum drug resistance
afz04010  MAPK signaling pathway
afz04012  ErbB signaling pathway
afz04014  Ras signaling pathway
afz04015  Rap1 signaling pathway
afz04022  cGMP-PKG signaling pathway
afz04024  cAMP signaling pathway
afz04062  Chemokine signaling pathway
afz04066  HIF-1 signaling pathway
afz04068  FoxO signaling pathway
afz04071  Sphingolipid signaling pathway
afz04072  Phospholipase D signaling pathway
afz04140  Autophagy - animal
afz04150  mTOR signaling pathway
afz04151  PI3K-Akt signaling pathway
afz04152  AMPK signaling pathway
afz04210  Apoptosis
afz04211  Longevity regulating pathway
afz04213  Longevity regulating pathway - multiple species
afz04218  Cellular senescence
afz04261  Adrenergic signaling in cardiomyocytes
afz04370  VEGF signaling pathway
afz04371  Apelin signaling pathway
afz04380  Osteoclast differentiation
afz04510  Focal adhesion
afz04550  Signaling pathways regulating pluripotency of stem cells
afz04611  Platelet activation
afz04613  Neutrophil extracellular trap formation
afz04620  Toll-like receptor signaling pathway
afz04625  C-type lectin receptor signaling pathway
afz04630  JAK-STAT signaling pathway
afz04660  T cell receptor signaling pathway
afz04662  B cell receptor signaling pathway
afz04664  Fc epsilon RI signaling pathway
afz04666  Fc gamma R-mediated phagocytosis
afz04668  TNF signaling pathway
afz04722  Neurotrophin signaling pathway
afz04725  Cholinergic synapse
afz04728  Dopaminergic synapse
afz04810  Regulation of actin cytoskeleton
afz04910  Insulin signaling pathway
afz04914  Progesterone-mediated oocyte maturation
afz04915  Estrogen signaling pathway
afz04917  Prolactin signaling pathway
afz04919  Thyroid hormone signaling pathway
afz04920  Adipocytokine signaling pathway
afz04922  Glucagon signaling pathway
afz04923  Regulation of lipolysis in adipocytes
afz04926  Relaxin signaling pathway
afz04929  GnRH secretion
afz04931  Insulin resistance
afz04932  Non-alcoholic fatty liver disease
afz04933  AGE-RAGE signaling pathway in diabetic complications
afz04935  Growth hormone synthesis, secretion and action
afz04936  Alcoholic liver disease
afz04973  Carbohydrate digestion and absorption
afz05010  Alzheimer disease
afz05017  Spinocerebellar ataxia
afz05132  Salmonella infection
afz05135  Yersinia infection
afz05142  Chagas disease
afz05145  Toxoplasmosis
afz05152  Tuberculosis
afz05160  Hepatitis C
afz05161  Hepatitis B
afz05162  Measles
afz05163  Human cytomegalovirus infection
afz05164  Influenza A
afz05165  Human papillomavirus infection
afz05166  Human T-cell leukemia virus 1 infection
afz05167  Kaposi sarcoma-associated herpesvirus infection
afz05168  Herpes simplex virus 1 infection
afz05169  Epstein-Barr virus infection
afz05170  Human immunodeficiency virus 1 infection
afz05200  Pathways in cancer
afz05205  Proteoglycans in cancer
afz05207  Chemical carcinogenesis - receptor activation
afz05208  Chemical carcinogenesis - reactive oxygen species
afz05210  Colorectal cancer
afz05211  Renal cell carcinoma
afz05212  Pancreatic cancer
afz05213  Endometrial cancer
afz05214  Glioma
afz05215  Prostate cancer
afz05218  Melanoma
afz05220  Chronic myeloid leukemia
afz05221  Acute myeloid leukemia
afz05222  Small cell lung cancer
afz05223  Non-small cell lung cancer
afz05224  Breast cancer
afz05225  Hepatocellular carcinoma
afz05226  Gastric cancer
afz05230  Central carbon metabolism in cancer
afz05231  Choline metabolism in cancer
afz05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
afz05415  Diabetic cardiomyopathy
afz05417  Lipid and atherosclerosis
afz05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:afz00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    127549861
   04012 ErbB signaling pathway
    127549861
   04014 Ras signaling pathway
    127549861
   04015 Rap1 signaling pathway
    127549861
   04370 VEGF signaling pathway
    127549861
   04371 Apelin signaling pathway
    127549861
   04630 JAK-STAT signaling pathway
    127549861
   04668 TNF signaling pathway
    127549861
   04066 HIF-1 signaling pathway
    127549861
   04068 FoxO signaling pathway
    127549861
   04072 Phospholipase D signaling pathway
    127549861
   04071 Sphingolipid signaling pathway
    127549861
   04024 cAMP signaling pathway
    127549861
   04022 cGMP-PKG signaling pathway
    127549861
   04151 PI3K-Akt signaling pathway
    127549861
   04152 AMPK signaling pathway
    127549861
   04150 mTOR signaling pathway
    127549861
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    127549861
  09143 Cell growth and death
   04210 Apoptosis
    127549861
   04218 Cellular senescence
    127549861
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    127549861
   04550 Signaling pathways regulating pluripotency of stem cells
    127549861
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    127549861
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    127549861
   04613 Neutrophil extracellular trap formation
    127549861
   04620 Toll-like receptor signaling pathway
    127549861
   04625 C-type lectin receptor signaling pathway
    127549861
   04660 T cell receptor signaling pathway
    127549861
   04662 B cell receptor signaling pathway
    127549861
   04664 Fc epsilon RI signaling pathway
    127549861
   04666 Fc gamma R-mediated phagocytosis
    127549861
   04062 Chemokine signaling pathway
    127549861
  09152 Endocrine system
   04910 Insulin signaling pathway
    127549861
   04922 Glucagon signaling pathway
    127549861
   04923 Regulation of lipolysis in adipocytes
    127549861
   04920 Adipocytokine signaling pathway
    127549861
   04929 GnRH secretion
    127549861
   04915 Estrogen signaling pathway
    127549861
   04914 Progesterone-mediated oocyte maturation
    127549861
   04917 Prolactin signaling pathway
    127549861
   04926 Relaxin signaling pathway
    127549861
   04935 Growth hormone synthesis, secretion and action
    127549861
   04919 Thyroid hormone signaling pathway
    127549861
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    127549861
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    127549861
  09156 Nervous system
   04725 Cholinergic synapse
    127549861
   04728 Dopaminergic synapse
    127549861
   04722 Neurotrophin signaling pathway
    127549861
  09158 Development and regeneration
   04380 Osteoclast differentiation
    127549861
  09149 Aging
   04211 Longevity regulating pathway
    127549861
   04213 Longevity regulating pathway - multiple species
    127549861
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    127549861
   05205 Proteoglycans in cancer
    127549861
   05207 Chemical carcinogenesis - receptor activation
    127549861
   05208 Chemical carcinogenesis - reactive oxygen species
    127549861
   05230 Central carbon metabolism in cancer
    127549861
   05231 Choline metabolism in cancer
    127549861
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    127549861
  09162 Cancer: specific types
   05210 Colorectal cancer
    127549861
   05212 Pancreatic cancer
    127549861
   05225 Hepatocellular carcinoma
    127549861
   05226 Gastric cancer
    127549861
   05214 Glioma
    127549861
   05221 Acute myeloid leukemia
    127549861
   05220 Chronic myeloid leukemia
    127549861
   05218 Melanoma
    127549861
   05211 Renal cell carcinoma
    127549861
   05215 Prostate cancer
    127549861
   05213 Endometrial cancer
    127549861
   05224 Breast cancer
    127549861
   05222 Small cell lung cancer
    127549861
   05223 Non-small cell lung cancer
    127549861
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    127549861
   05170 Human immunodeficiency virus 1 infection
    127549861
   05161 Hepatitis B
    127549861
   05160 Hepatitis C
    127549861
   05164 Influenza A
    127549861
   05162 Measles
    127549861
   05168 Herpes simplex virus 1 infection
    127549861
   05163 Human cytomegalovirus infection
    127549861
   05167 Kaposi sarcoma-associated herpesvirus infection
    127549861
   05169 Epstein-Barr virus infection
    127549861
   05165 Human papillomavirus infection
    127549861
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    127549861
   05135 Yersinia infection
    127549861
   05152 Tuberculosis
    127549861
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    127549861
   05142 Chagas disease
    127549861
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    127549861
   05017 Spinocerebellar ataxia
    127549861
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    127549861
   05418 Fluid shear stress and atherosclerosis
    127549861
   05415 Diabetic cardiomyopathy
    127549861
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    127549861
   04932 Non-alcoholic fatty liver disease
    127549861
   04931 Insulin resistance
    127549861
   04933 AGE-RAGE signaling pathway in diabetic complications
    127549861
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    127549861
   01524 Platinum drug resistance
    127549861
   01522 Endocrine resistance
    127549861
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:afz01001]
    127549861
Enzymes [BR:afz01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     127549861
Protein kinases [BR:afz01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   127549861
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 PH_11 Seadorna_VP7 PH_CERLI1 SOS1_NGEF_PH
Other DBs
NCBI-GeneID: 127549861
NCBI-ProteinID: XP_051834223
LinkDB
Position
2:367949889..368077736
AA seq 480 aa
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKSDGTFIGYKERPQDVDQRESPLNNFSVAQC
QLMKTERPKPNTFIIRCLQWTTVIERTFHVETPEEREEWTKAIQMVADSLKKQEEELMDF
RSGSPSDNSGAEEMEVSTTKPKHKVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLSPDAKSLLSGLLKKDPKQRLGGGPDDAKEIMQHKFFAGIVWQDVYEKK
LVPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDNMECVDNERRPHFPQFSYSASGTA
NT seq 1443 nt   +upstreamnt  +downstreamnt
atgaacgacgttgcgattgtgaaggagggctggctgcataagcgaggagaatacatcaaa
acgtggcggccacgctacttcttgctaaagagtgatgggaccttcattggctataaggaa
cggccacaagatgtggaccagcgggagtcacccctcaacaacttctcagttgcacaatgc
cagctgatgaagacagagcgacccaaacccaatacattcatcatccgctgcctgcagtgg
accacggtaattgagagaacgtttcacgtggagacccccgaggagcgggaagaatggacc
aaagccatccagatggtggctgacagcctaaaaaagcaggaggaagaactcatggacttc
cgatcaggctcacccagtgacaattctggggctgaggagatggaggtgtctacaacaaag
cccaaacacaaagtgacaatgaatgagttcgaatacctgaagctgctgggcaaaggcaca
tttgggaaggtgatcctagtgaaggagaaggcaactgggcgatattatgccatgaagatc
ctcaagaaggaagtgatcgtggccaaggatgaggtggctcatacgcttacggaaaatcga
gtcttacagaactccaggcacccattcctgacagcactgaagtactcgttccagacgcat
gaccgcctgtgctttgtgatggagtatgccaatggaggagagctatttttccatctttct
cgagaacgggtattctctgaagacagagccaggttctatggggcagagatcgtgtctgcg
ctggactacttgcattctgagaagaatgtggtatacagagacctcaagttggaaaaccta
atgctggacaaagatggtcacatcaaaatcactgacttcggtctgtgcaaggaggggatc
aaggatggtgctacgatgaagaccttctgcgggactccagaatatctggcccctgaggtg
ctagaagacaatgactatggacgggcagtggactggtggggcctgggagtggtcatgtat
gagatgatgtgtggccggctgcccttctacaaccaggatcatgagaagctgtttgagctg
atcctcatggaggagattcgatttcctcgaacactgtccccggacgccaagtctcttttg
tcagggttgctgaaaaaggaccccaagcagaggttaggtgggggaccagatgatgcaaaa
gagattatgcagcacaagttttttgctggcattgtatggcaagatgtctatgaaaaaaag
ctggtgcctccgtttaagccgcaggtcacatctgagaccgacaccaggtattttgatgag
gagtttacagcccagatgatcacaatcacccctcctgaccaagatgacaacatggaatgt
gtggataacgagagacggccccattttcctcagttctcatactctgctagtgggacagct
tga

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