KEGG   Antechinus flavipes (yellow-footed antechinus): 127551242
Entry
127551242         CDS       T08818                                 
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
afz  Antechinus flavipes (yellow-footed antechinus)
Pathway
afz01521  EGFR tyrosine kinase inhibitor resistance
afz01522  Endocrine resistance
afz04010  MAPK signaling pathway
afz04012  ErbB signaling pathway
afz04014  Ras signaling pathway
afz04015  Rap1 signaling pathway
afz04022  cGMP-PKG signaling pathway
afz04024  cAMP signaling pathway
afz04062  Chemokine signaling pathway
afz04066  HIF-1 signaling pathway
afz04068  FoxO signaling pathway
afz04071  Sphingolipid signaling pathway
afz04072  Phospholipase D signaling pathway
afz04114  Oocyte meiosis
afz04140  Autophagy - animal
afz04148  Efferocytosis
afz04150  mTOR signaling pathway
afz04151  PI3K-Akt signaling pathway
afz04210  Apoptosis
afz04218  Cellular senescence
afz04270  Vascular smooth muscle contraction
afz04370  VEGF signaling pathway
afz04371  Apelin signaling pathway
afz04380  Osteoclast differentiation
afz04510  Focal adhesion
afz04517  IgSF CAM signaling
afz04519  Cadherin signaling
afz04540  Gap junction
afz04550  Signaling pathways regulating pluripotency of stem cells
afz04613  Neutrophil extracellular trap formation
afz04620  Toll-like receptor signaling pathway
afz04650  Natural killer cell mediated cytotoxicity
afz04660  T cell receptor signaling pathway
afz04662  B cell receptor signaling pathway
afz04664  Fc epsilon RI signaling pathway
afz04666  Fc gamma R-mediated phagosome formation
afz04668  TNF signaling pathway
afz04720  Long-term potentiation
afz04722  Neurotrophin signaling pathway
afz04725  Cholinergic synapse
afz04726  Serotonergic synapse
afz04730  Long-term depression
afz04810  Regulation of actin cytoskeleton
afz04910  Insulin signaling pathway
afz04912  GnRH signaling pathway
afz04914  Progesterone-mediated oocyte maturation
afz04915  Estrogen signaling pathway
afz04916  Melanogenesis
afz04917  Prolactin signaling pathway
afz04919  Thyroid hormone signaling pathway
afz04921  Oxytocin signaling pathway
afz04926  Relaxin signaling pathway
afz04928  Parathyroid hormone synthesis, secretion and action
afz04929  GnRH secretion
afz04934  Cushing syndrome
afz04935  Growth hormone synthesis, secretion and action
afz05010  Alzheimer disease
afz05022  Pathways of neurodegeneration - multiple diseases
afz05034  Alcoholism
afz05132  Salmonella infection
afz05135  Yersinia infection
afz05160  Hepatitis C
afz05161  Hepatitis B
afz05163  Human cytomegalovirus infection
afz05164  Influenza A
afz05165  Human papillomavirus infection
afz05166  Human T-cell leukemia virus 1 infection
afz05167  Kaposi sarcoma-associated herpesvirus infection
afz05170  Human immunodeficiency virus 1 infection
afz05200  Pathways in cancer
afz05205  Proteoglycans in cancer
afz05206  MicroRNAs in cancer
afz05207  Chemical carcinogenesis - receptor activation
afz05208  Chemical carcinogenesis - reactive oxygen species
afz05210  Colorectal cancer
afz05211  Renal cell carcinoma
afz05212  Pancreatic cancer
afz05213  Endometrial cancer
afz05214  Glioma
afz05215  Prostate cancer
afz05216  Thyroid cancer
afz05218  Melanoma
afz05219  Bladder cancer
afz05220  Chronic myeloid leukemia
afz05221  Acute myeloid leukemia
afz05223  Non-small cell lung cancer
afz05224  Breast cancer
afz05225  Hepatocellular carcinoma
afz05226  Gastric cancer
afz05230  Central carbon metabolism in cancer
afz05231  Choline metabolism in cancer
afz05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:afz00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    127551242
   04012 ErbB signaling pathway
    127551242
   04014 Ras signaling pathway
    127551242
   04015 Rap1 signaling pathway
    127551242
   04370 VEGF signaling pathway
    127551242
   04371 Apelin signaling pathway
    127551242
   04668 TNF signaling pathway
    127551242
   04066 HIF-1 signaling pathway
    127551242
   04068 FoxO signaling pathway
    127551242
   04072 Phospholipase D signaling pathway
    127551242
   04071 Sphingolipid signaling pathway
    127551242
   04024 cAMP signaling pathway
    127551242
   04022 cGMP-PKG signaling pathway
    127551242
   04151 PI3K-Akt signaling pathway
    127551242
   04150 mTOR signaling pathway
    127551242
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    127551242
   04519 Cadherin signaling
    127551242
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    127551242
   04148 Efferocytosis
    127551242
  09143 Cell growth and death
   04114 Oocyte meiosis
    127551242
   04210 Apoptosis
    127551242
   04218 Cellular senescence
    127551242
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    127551242
   04540 Gap junction
    127551242
   04550 Signaling pathways regulating pluripotency of stem cells
    127551242
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    127551242
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    127551242
   04620 Toll-like receptor signaling pathway
    127551242
   04650 Natural killer cell mediated cytotoxicity
    127551242
   04660 T cell receptor signaling pathway
    127551242
   04662 B cell receptor signaling pathway
    127551242
   04664 Fc epsilon RI signaling pathway
    127551242
   04666 Fc gamma R-mediated phagosome formation
    127551242
   04062 Chemokine signaling pathway
    127551242
  09152 Endocrine system
   04910 Insulin signaling pathway
    127551242
   04929 GnRH secretion
    127551242
   04912 GnRH signaling pathway
    127551242
   04915 Estrogen signaling pathway
    127551242
   04914 Progesterone-mediated oocyte maturation
    127551242
   04917 Prolactin signaling pathway
    127551242
   04921 Oxytocin signaling pathway
    127551242
   04926 Relaxin signaling pathway
    127551242
   04935 Growth hormone synthesis, secretion and action
    127551242
   04919 Thyroid hormone signaling pathway
    127551242
   04928 Parathyroid hormone synthesis, secretion and action
    127551242
   04916 Melanogenesis
    127551242
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    127551242
  09156 Nervous system
   04725 Cholinergic synapse
    127551242
   04726 Serotonergic synapse
    127551242
   04720 Long-term potentiation
    127551242
   04730 Long-term depression
    127551242
   04722 Neurotrophin signaling pathway
    127551242
  09158 Development and regeneration
   04380 Osteoclast differentiation
    127551242
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    127551242
   05206 MicroRNAs in cancer
    127551242
   05205 Proteoglycans in cancer
    127551242
   05207 Chemical carcinogenesis - receptor activation
    127551242
   05208 Chemical carcinogenesis - reactive oxygen species
    127551242
   05230 Central carbon metabolism in cancer
    127551242
   05231 Choline metabolism in cancer
    127551242
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    127551242
  09162 Cancer: specific types
   05210 Colorectal cancer
    127551242
   05212 Pancreatic cancer
    127551242
   05225 Hepatocellular carcinoma
    127551242
   05226 Gastric cancer
    127551242
   05214 Glioma
    127551242
   05216 Thyroid cancer
    127551242
   05221 Acute myeloid leukemia
    127551242
   05220 Chronic myeloid leukemia
    127551242
   05218 Melanoma
    127551242
   05211 Renal cell carcinoma
    127551242
   05219 Bladder cancer
    127551242
   05215 Prostate cancer
    127551242
   05213 Endometrial cancer
    127551242
   05224 Breast cancer
    127551242
   05223 Non-small cell lung cancer
    127551242
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    127551242
   05170 Human immunodeficiency virus 1 infection
    127551242
   05161 Hepatitis B
    127551242
   05160 Hepatitis C
    127551242
   05164 Influenza A
    127551242
   05163 Human cytomegalovirus infection
    127551242
   05167 Kaposi sarcoma-associated herpesvirus infection
    127551242
   05165 Human papillomavirus infection
    127551242
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    127551242
   05135 Yersinia infection
    127551242
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    127551242
   05022 Pathways of neurodegeneration - multiple diseases
    127551242
  09165 Substance dependence
   05034 Alcoholism
    127551242
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    127551242
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    127551242
   01522 Endocrine resistance
    127551242
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:afz01001]
    127551242
Enzymes [BR:afz01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     127551242
Protein kinases [BR:afz01001]
 Serine/threonine kinases: STE group
  STE7 family
   127551242
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 127551242
NCBI-ProteinID: XP_051836772
LinkDB
Position
2
AA seq 393 aa
MPKKKPMPIQLNPTPDGSAINGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAIGRYPIPPPDSKELELMFGCPMEGDAPETSPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHTF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGI
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgatgcccattcagctgaacccgaccccggatggctctgcaatt
aacgggaccagctcagccgagaccaaccttgaggcgctgcagaagaagctggaggaatta
gaacttgatgaacagcagcgcaagcgtctggaggcttttctcacccagaaacagaaagtg
ggtgagctgaaggatgatgactttgagaagatcagtgaactgggagctgggaatggtggt
gtggtgttcaaagtttcccacaaaccctctggcctaatcatggcaaggaagttaattcat
ctggagatcaagccagcaattcggaaccagattatacgggaactgcaagtcctgcatgag
tgcaactctccatatattgtagggttttatggggcgttttacagcgatggggagatcagt
atctgcatggagcatatggatggaggatctttggaccaggtccttaagaaagctggaaga
attcctgagcaaattttggggaaagttagcattgctgtaataaagggtcttacatatctg
agagagaagcataagataatgcatagagatgtcaagccatccaacatcttggtgaattca
cgcggggaaatcaagctttgtgattttggcgtcagtgggcagctgattgattccatggct
aattccttcgtgggcacgaggtcctatatgtcgccagaacgactccagggaactcactac
tcggtacaatcagacatctggagcatggggctttctttggtggagatggccattggacga
tatcccattccaccaccagattctaaagagctagaactgatgtttggctgtccaatggaa
ggagatgcacctgagacatcaccacgaccaagaactcctggaaggcccctcagttcttat
ggaatggatagtcgaccaccaatggcaatttttgaactgttggattacatagtcaatgag
cctcctccaaagttgcccagtggagtctttagtctcgaatttcaagattttgtgaataaa
tgcctaataaaaaatcctgctgagagagctgacttaaagcaacttatggttcacactttt
atcaagaggtctgatgctgaggaagttgattttgcaggttggctctgctccaccataggc
cttaaccagcctagcacaccaacccatgctgctggcatctaa

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