KEGG   Antechinus flavipes (yellow-footed antechinus): 127552891
Entry
127552891         CDS       T08818                                 
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
afz  Antechinus flavipes (yellow-footed antechinus)
Pathway
afz00562  Inositol phosphate metabolism
afz01100  Metabolic pathways
afz01521  EGFR tyrosine kinase inhibitor resistance
afz01522  Endocrine resistance
afz01524  Platinum drug resistance
afz04012  ErbB signaling pathway
afz04014  Ras signaling pathway
afz04015  Rap1 signaling pathway
afz04024  cAMP signaling pathway
afz04062  Chemokine signaling pathway
afz04066  HIF-1 signaling pathway
afz04068  FoxO signaling pathway
afz04070  Phosphatidylinositol signaling system
afz04071  Sphingolipid signaling pathway
afz04072  Phospholipase D signaling pathway
afz04081  Hormone signaling
afz04140  Autophagy - animal
afz04150  mTOR signaling pathway
afz04151  PI3K-Akt signaling pathway
afz04152  AMPK signaling pathway
afz04210  Apoptosis
afz04211  Longevity regulating pathway
afz04213  Longevity regulating pathway - multiple species
afz04218  Cellular senescence
afz04360  Axon guidance
afz04370  VEGF signaling pathway
afz04380  Osteoclast differentiation
afz04510  Focal adhesion
afz04550  Signaling pathways regulating pluripotency of stem cells
afz04611  Platelet activation
afz04613  Neutrophil extracellular trap formation
afz04620  Toll-like receptor signaling pathway
afz04625  C-type lectin receptor signaling pathway
afz04630  JAK-STAT signaling pathway
afz04650  Natural killer cell mediated cytotoxicity
afz04660  T cell receptor signaling pathway
afz04662  B cell receptor signaling pathway
afz04664  Fc epsilon RI signaling pathway
afz04666  Fc gamma R-mediated phagocytosis
afz04668  TNF signaling pathway
afz04670  Leukocyte transendothelial migration
afz04722  Neurotrophin signaling pathway
afz04725  Cholinergic synapse
afz04750  Inflammatory mediator regulation of TRP channels
afz04810  Regulation of actin cytoskeleton
afz04910  Insulin signaling pathway
afz04914  Progesterone-mediated oocyte maturation
afz04915  Estrogen signaling pathway
afz04917  Prolactin signaling pathway
afz04919  Thyroid hormone signaling pathway
afz04923  Regulation of lipolysis in adipocytes
afz04926  Relaxin signaling pathway
afz04929  GnRH secretion
afz04930  Type II diabetes mellitus
afz04931  Insulin resistance
afz04932  Non-alcoholic fatty liver disease
afz04933  AGE-RAGE signaling pathway in diabetic complications
afz04935  Growth hormone synthesis, secretion and action
afz04960  Aldosterone-regulated sodium reabsorption
afz04973  Carbohydrate digestion and absorption
afz05010  Alzheimer disease
afz05017  Spinocerebellar ataxia
afz05020  Prion disease
afz05100  Bacterial invasion of epithelial cells
afz05132  Salmonella infection
afz05135  Yersinia infection
afz05142  Chagas disease
afz05146  Amoebiasis
afz05160  Hepatitis C
afz05161  Hepatitis B
afz05162  Measles
afz05163  Human cytomegalovirus infection
afz05164  Influenza A
afz05165  Human papillomavirus infection
afz05166  Human T-cell leukemia virus 1 infection
afz05167  Kaposi sarcoma-associated herpesvirus infection
afz05168  Herpes simplex virus 1 infection
afz05169  Epstein-Barr virus infection
afz05170  Human immunodeficiency virus 1 infection
afz05171  Coronavirus disease - COVID-19
afz05200  Pathways in cancer
afz05203  Viral carcinogenesis
afz05205  Proteoglycans in cancer
afz05206  MicroRNAs in cancer
afz05207  Chemical carcinogenesis - receptor activation
afz05208  Chemical carcinogenesis - reactive oxygen species
afz05210  Colorectal cancer
afz05211  Renal cell carcinoma
afz05212  Pancreatic cancer
afz05213  Endometrial cancer
afz05214  Glioma
afz05215  Prostate cancer
afz05218  Melanoma
afz05220  Chronic myeloid leukemia
afz05221  Acute myeloid leukemia
afz05222  Small cell lung cancer
afz05223  Non-small cell lung cancer
afz05224  Breast cancer
afz05225  Hepatocellular carcinoma
afz05226  Gastric cancer
afz05230  Central carbon metabolism in cancer
afz05231  Choline metabolism in cancer
afz05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
afz05415  Diabetic cardiomyopathy
afz05417  Lipid and atherosclerosis
afz05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:afz00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    127552891
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    127552891
   04014 Ras signaling pathway
    127552891
   04015 Rap1 signaling pathway
    127552891
   04370 VEGF signaling pathway
    127552891
   04630 JAK-STAT signaling pathway
    127552891
   04668 TNF signaling pathway
    127552891
   04066 HIF-1 signaling pathway
    127552891
   04068 FoxO signaling pathway
    127552891
   04070 Phosphatidylinositol signaling system
    127552891
   04072 Phospholipase D signaling pathway
    127552891
   04071 Sphingolipid signaling pathway
    127552891
   04024 cAMP signaling pathway
    127552891
   04151 PI3K-Akt signaling pathway
    127552891
   04152 AMPK signaling pathway
    127552891
   04150 mTOR signaling pathway
    127552891
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    127552891
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    127552891
  09143 Cell growth and death
   04210 Apoptosis
    127552891
   04218 Cellular senescence
    127552891
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    127552891
   04550 Signaling pathways regulating pluripotency of stem cells
    127552891
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    127552891
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    127552891
   04613 Neutrophil extracellular trap formation
    127552891
   04620 Toll-like receptor signaling pathway
    127552891
   04625 C-type lectin receptor signaling pathway
    127552891
   04650 Natural killer cell mediated cytotoxicity
    127552891
   04660 T cell receptor signaling pathway
    127552891
   04662 B cell receptor signaling pathway
    127552891
   04664 Fc epsilon RI signaling pathway
    127552891
   04666 Fc gamma R-mediated phagocytosis
    127552891
   04670 Leukocyte transendothelial migration
    127552891
   04062 Chemokine signaling pathway
    127552891
  09152 Endocrine system
   04910 Insulin signaling pathway
    127552891
   04923 Regulation of lipolysis in adipocytes
    127552891
   04929 GnRH secretion
    127552891
   04915 Estrogen signaling pathway
    127552891
   04914 Progesterone-mediated oocyte maturation
    127552891
   04917 Prolactin signaling pathway
    127552891
   04926 Relaxin signaling pathway
    127552891
   04935 Growth hormone synthesis, secretion and action
    127552891
   04919 Thyroid hormone signaling pathway
    127552891
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    127552891
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    127552891
  09156 Nervous system
   04725 Cholinergic synapse
    127552891
   04722 Neurotrophin signaling pathway
    127552891
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    127552891
  09158 Development and regeneration
   04360 Axon guidance
    127552891
   04380 Osteoclast differentiation
    127552891
  09149 Aging
   04211 Longevity regulating pathway
    127552891
   04213 Longevity regulating pathway - multiple species
    127552891
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    127552891
   05206 MicroRNAs in cancer
    127552891
   05205 Proteoglycans in cancer
    127552891
   05207 Chemical carcinogenesis - receptor activation
    127552891
   05208 Chemical carcinogenesis - reactive oxygen species
    127552891
   05203 Viral carcinogenesis
    127552891
   05230 Central carbon metabolism in cancer
    127552891
   05231 Choline metabolism in cancer
    127552891
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    127552891
  09162 Cancer: specific types
   05210 Colorectal cancer
    127552891
   05212 Pancreatic cancer
    127552891
   05225 Hepatocellular carcinoma
    127552891
   05226 Gastric cancer
    127552891
   05214 Glioma
    127552891
   05221 Acute myeloid leukemia
    127552891
   05220 Chronic myeloid leukemia
    127552891
   05218 Melanoma
    127552891
   05211 Renal cell carcinoma
    127552891
   05215 Prostate cancer
    127552891
   05213 Endometrial cancer
    127552891
   05224 Breast cancer
    127552891
   05222 Small cell lung cancer
    127552891
   05223 Non-small cell lung cancer
    127552891
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    127552891
   05170 Human immunodeficiency virus 1 infection
    127552891
   05161 Hepatitis B
    127552891
   05160 Hepatitis C
    127552891
   05171 Coronavirus disease - COVID-19
    127552891
   05164 Influenza A
    127552891
   05162 Measles
    127552891
   05168 Herpes simplex virus 1 infection
    127552891
   05163 Human cytomegalovirus infection
    127552891
   05167 Kaposi sarcoma-associated herpesvirus infection
    127552891
   05169 Epstein-Barr virus infection
    127552891
   05165 Human papillomavirus infection
    127552891
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    127552891
   05135 Yersinia infection
    127552891
   05100 Bacterial invasion of epithelial cells
    127552891
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    127552891
   05142 Chagas disease
    127552891
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    127552891
   05017 Spinocerebellar ataxia
    127552891
   05020 Prion disease
    127552891
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    127552891
   05418 Fluid shear stress and atherosclerosis
    127552891
   05415 Diabetic cardiomyopathy
    127552891
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    127552891
   04932 Non-alcoholic fatty liver disease
    127552891
   04931 Insulin resistance
    127552891
   04933 AGE-RAGE signaling pathway in diabetic complications
    127552891
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    127552891
   01524 Platinum drug resistance
    127552891
   01522 Endocrine resistance
    127552891
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:afz04131]
    127552891
Enzymes [BR:afz01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     127552891
Membrane trafficking [BR:afz04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    127552891
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_p85B PI3K_rbd DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 127552891
NCBI-ProteinID: XP_051839160
LinkDB
Position
3:36968365..37053096
AA seq 1091 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDETSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDVHAPHSRALYVYPPNVESSPELPKH
IYSKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEHVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYLLEKYPLSQYKALSLKKKKYRHQSSSPPSSNLLQYIRSCI
MLGRMPNLMLMAKESLYTQLPLDTFTMPSYSRRISTATPYMNGEASTKSLWGVNSALRIR
ILCATYVNVNIRDIDKIYVRTGICHGGEPLCDNVNTQRVPCSNPRWNEWLMYDIYIPDLP
RAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLN
PIGVTGSNPNKETPCLELEFDWFSNPVKFPDMSVIEEHANWTVSRELGFNYSHAGLSNRI
ARDNELRENDKEQLRAICTRDPLSEITEQEKDFLWSHRHYCVNIPEILPKLLLSVKWNSR
DEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRAFAVRCLEKYLTDDKLSQYLIQLVQ
VLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGM
YLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDYMDALQGFISPLNP
AHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQII
RIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTL
HQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHF
LDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANL
FINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDW
IFHTIKQHALN
NT seq 3276 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatccggtgaattatggggcatccatttgatgcccccaagaatc
ttagtagaatgtctactacctaatggaatgatagtgactttagaatgcctccgtgaggct
acattagtaactattaaacatgagctatttaaagaagcaaggaaataccctcttcaccag
ctccttcaggatgaaacttcttacattttcgtaagtgttactcaagaagcagaaagagaa
gaattttttgatgaaacacggcgactttgtgacctgcggctttttcagccctttctaaaa
gtcatcgaacctgtaggaaaccgagaagaaaaaattctcaatcgagaaattggttttgct
attggtatgcctgtttgtgaatttgacatggttaaagatccagaagtacaagacttccga
agaaatattcttaatgtttgtaaagaagctgtggacctgagggatgtccatgcaccccat
agtagagcattatatgtttatcctccaaatgtagaatcttcaccagaattgccaaagcac
atatacagtaaattagataaagggcaaataatagtggtgatttgggtgatagtttcccca
aacaacgacaagcagaagtacactttaaaaatcaatcacgactgtgtaccagaacatgtg
atcgctgaagcaatccggaaaaaaacacggagtatgttactatcatctgagcagctgaag
ctctgtgttttagagtatcagggcaaatatattttaaaagtgtgtggatgtgatgagtat
ttgctagaaaaatatcctcttagccaatataaggcattgtctctaaagaaaaaaaaatac
aggcaccaatcttcctcccctccctcctctaatttgttacagtacataagaagctgtata
atgcttggtcggatgcccaatctgatgctgatggctaaagaaagtctttacacccagcta
ccactggatacttttacaatgccatcttattccaggcgaatctctacagccacaccgtac
atgaatggagaagcttcaaccaaatccctttggggcgtaaatagtgcactccgcataaga
attctttgtgcaacttatgtaaatgtaaatattcgagacattgacaagatctatgttcga
acaggtatttgccatgggggagagccattatgtgacaatgtgaatactcaaagagtacct
tgttccaatcccaggtggaatgaatggctaatgtatgatatatacattcctgatcttcca
cgtgctgctcgactttgcctttccatttgttctgttaaaggcaggaaaggagcaaaagag
gaacattgcccattggcttggggaaatattaacctctttgattatacagacactctggta
tcaggaaaaatggctttgaatctgtggccagtacctcatggattagaagacttgctgaat
cctattggagttactggatcaaatcccaataaggaaactccatgtttagagctggaattt
gactggtttagcaatcctgtaaagttcccagatatgtcagtaattgaagaacatgcaaat
tggactgtatctcgagaactaggattcaactattcccatgctgggctgagtaataggata
gctcgagataatgaattgagagaaaatgacaaagaacagctccgggcgatttgtacacga
gaccctctgtctgagatcactgagcaagaaaaggacttcctgtggagtcataggcattat
tgtgtcaatataccagaaattctacctaaactacttctgtctgttaagtggaattctaga
gatgaagtagcccagatgtattgcttggtaaaagattggcccccaatcaaaccagaacag
gccatggaacttttagactgtaattatccagaccctatggttcgagcttttgctgttcga
tgcttggagaaatatttaactgatgacaaactttctcagtacttaattcaactggttcag
gttctgaagtatgaacaatatttggataacctgcttgtgaggtttttactcaagaaagca
ctaacaaatcaaaggatagggcactttttcttttggcatttaaagtctgaaatgcataat
aaaactgtcagccagagatttggtttgcttttggagtcatactgtcgagcatgtgggatg
tatctaaagcatctgaatcggcaggtagaggccatggagaaactgatcaacctcaccgac
attctcaagcaggagaagaaggatgagacacaaaaggtacagatgaagttcttggttgag
caaatgagacgacctgattacatggatgctttacaaggctttatctctccccttaatcct
gctcatcaattaggaaatctcaggctcgaagagtgtcggattatgtcatcagcaaaaaga
ccactgtggttgaattgggagaacccagacatcatgtcagagttactatttcagaacaat
gagatcatctttaaaaatggggatgacttacggcaggatatgctaacccttcagatcatt
cggattatggaaaatatctggcaaaatcagggtcttgatcttcggatgttaccttatggt
tgtctatcaatcggggactgtgttggcctcattgaggtggtcagaaattcccacactatc
atgcagattcaatgtaaagggggcctgaaaggggcgttgcagttcaacagccatacatta
catcagtggctcaaagacaagaataaaggagaaatatatgatgcagccatcgatttgttt
acacgttcctgtgctggatactgtgtagctaccttcattttgggaattggtgatcgacac
aatagcaatatcatggtgaaagatgatggtcaactattccacatagactttggacacttt
ttggatcacaagaagaagaaatttggctataaacgagagcgtgtgcccttcgtcttgacg
caagatttcttaattgtgattagtaaaggagcccaagaatgtacaaagacaagagagttt
gagaggtttcaggaaatgtgctataaggcttacttagctattcgacaacatgccaatctc
ttcatcaatctcttctccatgatgcttggctccggaatgcccgaacttcagtcttttgac
gacatcgcctatattcgaaagaccctggccttggataagactgagcaggaggctttggag
tatttcatgaagcagatgaatgatgctcatcatgggggctggacaaccaaaatggattgg
atttttcatacgataaagcagcacgctttgaactga

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