Entry |
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Symbol |
tylG1
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Name |
(KEGG) tylactone synthase starter module and modules 1 & 2
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KO |
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Taxonomy |
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Lineage |
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces |
Organism |
Streptomyces fradiae
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Module |
1906_M00773 | Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin |
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SSDB |
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Motif |
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Other DBs |
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Structure |
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LinkDB |
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AA seq |
4472 aa
MSSALRRAVQSNCGYGDLMTSNTAAQNTGDQEDVDGPDSTHGGEIAVVGMSCRLPGAAGV
EEFWELLRSGRGMPTRQDDGTWRAALEDHAGFDAGFFGMNARQAAATDPQHRLMLELGWE
ALEDAGIVPGDLTGTDTGVFAGVASDDYAVLTRRSAVSAGGYTATGLHRALAANRLSHFL
GLRGPSLVVDSAQSASLVAVQLACESLRRGETSLAVAGGVNLILTEESTTVMERMGALSP
DGRCHTFDARANGYVRGEGGGAVVLKPLDAALADGDRVYCVIKGGAVNNDGGGASLTTPD
REAQEAVLRQAYRRAGVSTGAVRYVELHGTGTRAGDPVEAAALGAVLGAGADSGRSTPLA
VGSVKTNVGHLEGAAGIVGLIKATLCVRKGELVPSLNFSTPNPDIPLDDLRLRVQTERQE
WNEEDDRPRVAGVSSFGMGGTNVHLVIAEAPAAAGSSGAGGSGAGSGAGISAVSGVVPVV
VSGRSRVVVREAAGRLAEVVEAGGVGLADVAVTMADRSRFGYRAVVLARGEAELAGRLRA
LAGGDPDAGVVTGAVLDGGVVVGAAPGGAGAAGGAGAAGGAGGGGVVLVFPGQGTQWVGM
GAGLLGSSEVFAASMRECARALSVHVGWDLLEVVSGGAGLERVDVVQPVTWAVMVSLARY
WQAMGVDVAAVVGHSQGEIAAATVAGALSLEDAAAVVALRAGLIGRYLAGRGAMAAVPLP
AGEVEAGLAKWPGVEVAAVNGPASTVVSGDRRAVAGYVAVCQAEGVQARLIPVDYASHSR
HVEDLKGELERVLSGIRPRSPRVPVCSTVAGEQPGEPVFDAGYWFRNLRNRVEFSAVVGG
LLEEGHRRFIEVSAHPVLVHAIEQTAEAADRSVHATGTLRRQDDSPHRLLTSTAEAWAHG
ATLTWDPALPPGHLTTLPTYPFNHHHYWLDTIDGGGGDDATQEKESGPLTRELRGLPSSQ
KQLGFLLDLVCRHTAVVLGLDTAAEVDPDLSFKKQGIQSMTGVELRNRLLTETGLALPTT
LVYDRPTPRALAQFLHTELLDGSPSGSVLAPAQKSFEAQEPIAVVGMGCRFPGGVGSPEA
LWRLVVEGVDAVSPFPGDRGWDVEGLYDPEPGVAGKSYVREGGFLHDAAEFDAEFFGISP
REAVAMDPQQRLLLETSWEAIERAGIDPHSLHGSRTGVYAGVMPQEYGPRLAEGAEGSDG
YLLTGTSGSVVSGRVAYTLGLEGPAVTVDTACSSSLVALHLAVQALRGGECDMALAGGVT
VMAGPGMFVEFSRQRGLAADGRCKAFADGADGTAWAEGAGVVLVERLSDARRLGHPVLAV
VCGSAVNQDGASNGLTAPSGPSQERVIRQALGNARLTVADVDVVEAHGTGTRLGDPIEAQ
ALLGTYGRDRDGGRPVWLGSLKSNIGHAQAAAGVAGVIKMVLAMRYGWLPRTLHVDEPSR
HVDWSAGGVWLLTEAREWPGVDRPRRAAVSAFGVSGTNAHLILEAPDTAEAESATTPVRS
EVSESAAVLDARSGVVPVVVSGRSRVVVREAAGRLAEVVEAGGVGLADVAVTMAGRSRFG
YRAVVLARGEAELAGRLRALAGGDPDAGVVTGAVVDPETGSGGGGVVLVFPGQGTQWVGM
GAGLLGSSEVFAASMRECARALSVHVEWDLLEVVSGGAGLERVDVVQPVTWAVMVSLARY
WQAMGVDVAAVVGHSQGEIAAATVAGALSLEDAAAVVALRAGLIGRYLAGRGAMAAVPLP
AGEVEAGLAKWPGVEVAAVNGPASTVVSGDRRAVAGYVAVCQAEGVQARLIPVDYASHSR
HVEDLKGELERVLSGIRPRSPRVPVCSTVAGEQPGEPVFDAGYWFRNLRNRVEFSAVVGG
LLEEGHRRFIEVSAHPVLVHAIEQTAEAADRSVHATGTLRRQDDSPHRLLTSTAEAWAHG
ATLTWDPALPPGHLTTLPTYPFNHHHYWLDTTPTTPATTTQSPTDAWRYRVTWKALTESS
PVRPHSIGRCLLVAPPTTDGELLDGLTTVLSERGASVARLEVPIGARRAEVAELLKPSME
SAGEENTTVVSLLGLVPSTDAVRTSIALLQAVSDIGVPAARVWALTRRAVAVVPGETPQD
AGAQLWGFGRVAALELPDIWGGLIDLPETAELTRTPETSQPPQTPERLPQTPNRRALELA
AAVLAGRDGEDQVAVRASGIYGRRVSRAAAAGAASWQPSGTVLITGGMGAIGRRLARRLA
AEGAERLVLTSRRGPEAPGAAELAEELRGHGCEVVHAACDVAERDALAALVTAYPPNAVF
HTAGILDDAVIDTLSPESFETVRGAKVCGAELLHQLTADIKGLDAFVLFSSVTGTWGNAG
QGAYAAANAALDALAERRRAAGLPATSVAWGLWGGGGMAAGAGEESLSRRGLRAMDPDAA
VDALLGAMGRNDVCVTVVDVDWERFAPATNAIRPGRLFDTVPEAREALTAAGTTSATPDG
APELARRLSMLNETERLRKLVELVRTEAAFVLRHPNTDAIGAERPFKSAGFDSLTSLELR
NRLNAGTGLKLPATVIFDHPSPTALARLLLDRLTGAGAPAPAADEPPLPVAVADDDPVVI
VGMACRFPGGAGTPEALWKLVTEERDVIGAAPTDRGWDLDSVYDPEPGVAGKTYVREGGF
LHDAAEFDAEFFGISPREAVAMDPQQRLLLETSWEAIERAGIDPHSLHGSRTGVYVGLTH
QEYASRLHEAPEEYEGYLLTGKSASVVSGRISYTLGLEGPSLSIDTACSSSLVALHNAAQ
ALRGGECDMALAGGVTVMAAPGLFVEFSRQRGLAADGRCKAFADGADGTAWAEGAGVVLV
ERLSDARRLGHPVLAVVCGSAVNQDGASNGLTAPSGPSQERVIRQALANARLTVADVDVV
EAHGTGTRLGDPIEAQALLGTYGRDRDAECPVWLGSLKSNIGHAQAAAGVAGVIKMVLAM
RYGWLPRTLHVDEPSRHVDWSAGGVRLLTEAREWPGVDRPRRAAVSAFGVSGTNAHLILE
APEALEALEATDAPEAPEAPEAPDVTDVTEALEAPDATEAEGAKAPGSPEEAQPAVGVVP
VVVSGRSRVVVREAAGRLAEVVEAGGVGLADVAVTMAGRSRFGYRAVVLARGEAELAGRL
RALAGGDPDAGVVTGAVVDPETGSGGGGVVLVFPGQGTQWVGMGAGLLGSSEVFAASMRE
CARALSVHVEWDLLEVVSGGAGLERVDVVQPVTWAVMVSLARYWQAMGVDVAAVVGHSQG
EIAAATVAGALSLEDAAAVVALRAGLIGRYLAGRGAMAAVPLPAGEVEAGLAKWPGVQVA
AVNGPASTVVSGDRRAVAGYVAVCQAEGVQARLIPVDYASHSRHVEDLKGELERVLSGIR
PRSPRVPVCSTVAGEQPGEPVFDAGYWFRNLRNRVEFSAVVGGLLEQGHRRFIEVSAHPV
LVHAIEQTAEAADRSVHATGTLRRQDDSPHRLLTSTAEAWAHGATLTWDPALPPGHLTTL
PTYPFNHHHYWAVTSPAGVGDAAAGRFGMTWEDHPFLRGGLPLADSGERVFAGRLAGSEH
DWLTDHAVSGVTLLPGTAFVEFALHAGAATGCGRLEELSVEAPLVLPAAGGVRVQMRVSA
ADESGRRRVAIHSAPEAAVHSAAEGGDSAGVWTRHGEGTLVPDPEPTPPDADWARAWPPA
GERVEPAELYERFGALGYEYGEAFAGVRAVWRQPDALLAEVLLPDRASTGAGRFGVHPAL
LDAALQPWIAGGLLEVPEDAVLLPFAWQGVSLYATGAGALRVRLTKAGDGAVSLQAADTS
GAAVLSLGALVMRPLARRKLDVLLGTDAGERSLYRVEWQPRLLPAGPPRSWAVLGPDADR
LAGTPGLGDQPDGGPTALYPEVRALRKALAAGAPRPEAVVLPVLSGAGATPESVRQTTER
CLTALQDWLDAEELVDTPLIVLTRGAVAAVPGEEIGDLACAGVWGLVRSARSEHPGRFAL
VDTDGHPDDRTALPLALRAVLDGAGQLSLRAGTARTPVLLRAGTPEEQRGPAFDPAGTVL
VTGATGTLGRLLARHLAAEHGVRHLLLLSRGGRAAEGADELAAELAGLEAEPCFAACDAA
DREALARVLAEVPADRPLTGVIHAAGVLDDGTLDALTPERIGTVMRPKADAALNLHELTR
TSPLSVFAVFSGAAGILGRPGQANYAAANTFLDALAQHRRAHGLPAVSLAWGLWGGATGM
TGHLSGTDLRRMRRSGIAPMTHDQGLALFDRALAASAEDPLLVPMRLDLAALVRERAEHG
PDAVPGPLLGLLPARAAVRQAAAPVRGGAPAPAGGEGTAERLAGLGEEARLRELVRLVRA
EVSGVLGYSGPDAVEPGRPFKDLGFDSLTAVELRNRLGAATGLRLPTALVFDRPTSQAVA
EYLAAELAGPRDGGDTAAAAFEGLEALAAAVGALAEDDLRRDVLRRRLTELAAALTPQGR
NPSAPAPAPSDLDERLDSANDDDLFAFIEEQL |
Comment |
Unpublished sequence data: DeHoff BS, Sutton KL, Rosteck PR Jr (1996).
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