KEGG   Addendum: AAF82409
Entry
AAF82409          CDS       T10000                                 
Symbol
oleAII
Name
(KEGG) 8,8a-deoxyoleandolide synthase 2
  KO
K24565  8,8a-deoxyoleandolide synthase 2
Taxonomy
TAX:1890
  Lineage
Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces
Organism
Streptomyces antibioticus
SSDB
Motif
Pfam: ketoacyl-synt Acyl_transf_1 KR Ketoacyl-synt_C PKS_DH_N KAsynt_C_assoc PP-binding PS-DH ADH_zinc_N_2 adh_short SpnB_Rossmann Thiolase_N PKS_DE ADH_zinc_N CurL-like_PKS_C ADH_N adh_short_C2 Docking RhiE-like_linker Epimerase Sacchrp_dh_NADP DUF7080 ACP_syn_III DUF4129 Shikimate_DH GDP_Man_Dehyd Glu_dehyd_C
Other DBs
NCBI-ProteinID: AAF82409
GB: AF220951
UniProt: Q9KIV3
LinkDB
AA seq 3816 aa
MTNDEKIVEYLKRATVDLRKARHRIWELEDEPIAITSMACHFPGGIESPEQLWELLSAGG
EVLSEFPDDRGWDLDEIYHPDPEHSGTSYVRHGGFLDHATQFDTDFFGISPREALAMDPQ
QRLLLETSWQLFERAGVDPHTLKGSRTGVFVGAAHMGYADRVDTPPAEAEGYLLTGNASA
VVSGRISYTFGLEGPAVTVDTACSSSLVALHLAVQALRRGECSLAVVGGVAVMSDPKVFV
EFSRQRGLARDGRSKAFAASADGFGFAEGVSLLLLERLSDARRLGHRVLAVVRGSAVNQD
GASNGLAAPNGPSQQRVIRAALADAGLAPADVDVVEAHGTGTRLGDPIEAQALLATYGQG
RTSGRPVWLGSVKSNIGHTQAAAGVAGVMKMVLALERGVVPKTLHVDEPSPHVDWSTGAV
ELLTEERPWEPEAERLRRAGISAFGVSGTNAHVIVEEAPAEPEPEPEPGTRVVAAGDLVV
PWVVSGRDAGALRAQAARLAAHVSSTGAGVVDVGWSLVATRSVFEHRAVMVGTDLDSMAG
SLAGFAAGGVVPGVVSGVAPAEGRRVVFVFPGQGSQWVGMAAGLLDACPVFAEAVAECAA
VLDPLTGWSLVEVLRGGEAVLGRVDVVQPALWAVMVSLARTWRYYGVEPAAVVGHSQGEI
AAACVAGGLSLADGARVVVLRSRAIARIAGGGGMVSVSLPAGRVRTMLDTYGGRLSVAAV
NGPSSTVVSGDAQALDELLAGCEREGVRARRVPVDYASHSAQMDQLRDELLEALADITPQ
HSSVPFFSTVTADWLDTTALDAGYWFTNLRETVRFQEAVEGLVAQGMGAFVECSPHPVLV
PGIEQTLDTVEADAVALGSLRRDEGGLGRFLTSLAEAFVQGVPVDWSRTFEGASPRTVDL
PTYPFQRQRFWLEGSPALSSNGVEGEADVAFWDAVEREDSAVVAEELGIDAKALHMTLPA
LSSWRRRERQRRKVQRWRYRVEWKRLPNSRAQESLQGGWLLVVPQGRAGDVRVTQSVAEV
AAKGGEATVLEVDALHPDRAAYAEALTRWPGVRGVVSFLAWEEQALAEHPVLSAGLAASL
ALAQALIDVGGSGESAPRLWLVTEAAVVIGAADTGAVIDPVHAQLWGFGRVLALEHPELW
GGLIDLPAVAGEPGSITDHAHADLLATVLATMVQAAARGEDQVAVRTTGTYVPRLVRSGG
SAHSGARRWQPRDTVLVTGGMGPLTAHIVRWLADNGADQVVLLGGQGADGEAEALRAEFD
GHTTKIELADVDTEDSDALRSLLDRTTGEHPLRAVIHAPTVVEFASVAESDLVRFARTIS
SKIAGVEQLDEVLSGIDTAHDVVFFSSVAGVWGSAGQSAYAAGNAFLDAVAQHRRLRGLP
GTSVAWTPWDDDRSLASLGDSYLDRRGLRALSIPGALASLQEVLDQDEVHAVVADVDWER
FYAGFSAVRRTSFFDDVHDAHRPALSTAATNDGQARDEDGGTELVRRLRPLTETEQQREL
VSLVQSEVAAVLGHSSTDAVQPQRAFREIGFDSLTAVQLRNRLTATTGMRLPTTLVFDYP
TTNGLAEYLRSELFGVSGAPADLSVVRNADEEDDPVVIVGMACRFPGGIDTPEAFWKLLE
AGGDVISELPANRGWDMERLLNPDPEAKGTSATRYGGFLYDAGEFDAAFFGISPREALAM
DPQQRLLLETVWELIESAGVAPDSLHRSRTGTFIGSNGQFYAPLLWNSGGDLEGYQGVGN
AGSVMSGRVAYSLGLEGPAVTVDTACSSSLVALHLAVQALRRGECSLAIAGGVTVMSTPD
SFVEFSRQQGLSEDGRCKAFASTADGFGLAEGVSALLVERLSDARRLGHRVLAVVRGSAV
NQDGASNGLTAPNGPSQQRVIRAALADAGLAPADVDVVEAHGTGTRLGDPIEAQALLATY
GQGRAGGRPVVLGSVKSNIGHTQAAAGVAGVMKMVLALERGVVPKTLHVDEPSPHVDWSA
GEVELAVEAVPWSRGGRVRRAGVSSFGISGTNAHVIVEEAPAEPEPEPGTRVVAAGDLVV
PWVVSGRDAGALREQAARLAAHVSSTGAGVVDVGWSLVATRSVFEHRAVMVGSELDSMAE
SLAGFAAGGVVPGVVSGVAPAEGRRVVFVFPGQGSQWVGMAAGLLDACPVFAEAVAECAA
VLDPVTGWSLVEVLRGGGEAVLGRVDVVQPALWAVMVSLARTWRYYGVEPAAVVGHSQGE
IAAACVAGGLSLADGARVVVLRSRAIARIAGGGGMVSVGLSAERVRTMLDTYGGRVSVAA
VNGPSSTVVSGDVQALDELLAGCEREGVRARRVPVDYASHSAQMDQLRDELLEALADITP
QHSSVPFFSTVTADWLDTTALDAGYWFTNLRETVRFQEAVEGLVAQGMGAFVECSPHPVL
VPGIEQTLDALDQNAAVLGSLRRDEGGLDRLLTSLAEAFVQGVPVDWTHAFEGMTPRTVD
LPTYPFQRQHYWPKPAPAPGANLGDVASVGLTAAGHPLLGAVVEMPDSDGLVLTGQISLR
THPWLADHEVLGSVLLPGTAFVELAVQAADRAGYDVLDELTLEAPLVLPDRGGIQVRLAL
GPSEADGRRSLQLHSRPEEAAGFHRWTRHASGFVVPGGTGAARPTEPAGVWPPAGAEPVA
LASDRYARLVERGYTYGPSFQGLHTAWRHGDDVYAEVALPEGTPADGYALHPALLDAAVQ
AVGLGSFVEDPGQVYLPFLWSDVTLHATGATSLRVRVSPAGPDTVALALADPAGAPVATV
GALRLRTTSAAQLARARGSAEHAMFRVEWVEEGSAADRCRGGAGGTTYEGERAAEAGAAA
GTWAVLGPRVPAAVRTMGVDVVTALDTPDHPADPQSLADLAALGDTVPDVVVVTSLLSLA
SGADSPLGNRPRPTAAEQDTAATVAGVHSALHAALDLVQAWLADERHTASRLVLVTRHAM
TVAESDPEPDLLLAPVWGLVRSAQAENPGRFVLADIDGDEASWDALPRAVASAASEVAIR
AGAVYVPRLARATDEGLVVADEAAGPWRLDVTEAGTLANLALVPCPDASRPLGPDEVRIA
VRAAGVNFRDVLLALGMYPDEGLMGAEAAGVVTEVGGGVTTLAPGDRVMGLVTGGFGPVA
VTHHRMLVRMPRGWSFAEAASVPVAFLTAYYALHDLAGLRGGESVLVHSAAGGVGMAAVQ
LARHWDAEVFGTASKGKWDVLAAQGLDEEHIGSSRTTEFEQRFRATSGGRGIDVVLNALS
GDFVDASARLLREGGRFVEMGKTDIRTDLGVVGADGVPDIRYVAFDLAEAGAERIGQMLD
EIMALFDAGVLRLPPLRAWPVRRAHEALRFVSQARHVGKVVLTVPAALDAEGTVLITGAG
TLGALVARHLVTEHDVRRLLLVSRSGVAPDLAAELGALGAEVTVAACDVANRKALKALLE
DIPPEHPVTGIVHTAGVLDDGVVSGLTPERVDTVLKPKVDAALTLESVIGELDLDPALFV
IFSSAASMLGGPGQGSYAAANQFLDTLARHRARRGLTSVSLGWGLWHEASGLTGGLADID
RDRMSRAGIAPMPTDEALHLFDRATELGDPVLLPMRLNEAALEDRAADGTLPPLLSGLVR
VRHRPSARAGTATAAPATGPEAFARELAAAPDPRRALRDLVRGHVALVLGHSGPEAIDAE
QAFRDIGFDSLTAVELRNRLNAETGLRLPGTLVFDYPNPSALADHLLELLAPATQPTAAP
LLAELERVEQLLSAAASPGGPASAVDEETRTLIATRLATLASQWTHLPVGSPGNADNRSG
PGESGQAQESGATGEHTAAWTSDDDLFAFLDKRLET
Reference
PMID:10908114
  Authors
Shah S, Xue Q, Tang L, Carney JR, Betlach M, McDaniel R
  Title
Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin.
  Journal
J Antibiot (Tokyo) 53:502-8 (2000)
DOI:10.7164/antibiotics.53.502

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